Clinical trials: Inflammatory Bowel System
Inflammatory Bowel Disease, Crohn's Disease
SSAT 054: Non Genetic Factors in the Pathogenesis of IBD in Twins
This study aims to investigate the role of non-genetic factors in the pathogenesis of inflammatory bowel disease.An exploratory study to investigate differences between the epigenome, microbiota and functional immunology in twins…
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT02383953
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Inflammatory Bowel Diseases
ImmuneSense™ IBD Study
This study will enroll adult and pediatric participants across 3 phases: Research phase, Clinical Validation (CV) and Analytical Validation (AV) phase.
- Trial name
- NCT05769829
- Where
- 6 sites in United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Adaptive Biotechnologies
Juvenile Idiopathic Arthritis, Diabetes type1
Host-microbiota-environment Interactions
Two types of inflammatory and autoimmune diseases (excluding monogenic diseases) can be distinguished in children: those similar to adult diseases but with an early onset (type 1 diabetes, inflammatory diseases of the…
- Conditions
- Juvenile Idiopathic Arthritis, Diabetes type1, Inflammatory Bowel Diseases
- Trial name
- MIP-1 (NCT05176795)
- Testing
- Stool sample
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Crohn's Disease, Rheumatoid Arthritis
OTIS Cimzia Pregnancy Registry
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Crohn's Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01797224
- Where
- United States
- Volunteers
- 925 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Colorectal Cancer, Inflammatory Bowel Diseases
The Deep South Surgical Equity Research Network: Addressing Socioecological Determinants of Health
Rationale: Older African Americans undergoing surgery are a vulnerable and growing population at high risk for poor surgical outcomes and disparities.
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Diverticular Diseases, Social Behavior
- Trial name
- NCT05345054
- Testing
- no intervention
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Inflammatory Bowel Disease
Randomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy
This investigation is designed to compare lubiprostone and placebo for cleansing and propulsion in preparation for capsule endoscopy.
- Trial name
- NCT00746395
- Testing
- Lubiprostone
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Tuberculosis, Gastric Cancer
Volatiles in Breath and Headspace Analysis - Diagnostic Markers
Detection of Volatile Organic Compounds (VOC) directly from tissue by headspace analysis (skin, surgery material, other tissue) and exhaled breath is feasible using affordable user-friendly novel nano-chemo sensors that can…
- Conditions
- Tuberculosis, Gastric Cancer, Peptic Ulcer, Atrophic Gastritis
- Trial name
- Volatolome (NCT03228095)
- Testing
- VOC detection in breath and in skin headspace, Breath sampling, Upper endoscopy with biopsies
- Where
- Latvia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Crohn Disease
Early MRI Prediction of Crohns
The investigators plan a prospective study designed to optimize and translate noncontrast, novel Magnetic Resonance Imaging (MRI) techniques for detecting and measuring intestinal inflammation as well as for allowing early…
- Trial name
- NCT03340519
- Testing
- MR Imaging
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Inflammatory Bowel Disease (IBD)
Prospective Intestinal Ultrasound Study for Artificial Intelligence Algorithm Development
This observational study will use intestinal ultrasound images to help develop computer programs that may make it easier to assess bowel inflammation.
- Trial name
- PSIUSAD (NCT07814274)
- Testing
- De-identified Intestinal Ultrasound Data Collection
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Crohn Disease
PMA-Zeolite-Clinoptilolite Effects in Crohn Disease
This pilot study aims to evaluate the safety and efficacy of PMA-zeolite when used in patients with uncontrolled CD (Crohn´s disease).
- Trial name
- NCT04370535
- Testing
- cellulose, PMA-zeolite
- Where
- 3 sites in Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ciim Plus, d.o.o.
IBD (Inflammatory Bowel Disease)
A Phase I Study of INT-210 Capsules in Healthy Adult Subjects (INT-210-I101)
A Phase Ⅰ, Single and Multiple Ascending Dose escalation, and Food-Effect Study of the Safety, Tolerability and Pharmacokinetics of INT-210 Capsules in Healthy Adult Voluteers.
- Trial name
- INT-210-I101 (NCT07616791)
- Testing
- INT-210 Capsule
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Innatus Therapeutics (Shanghai) Co., Ltd.
Oral Health in Children With Inflammatory Bowel Disease
Oral Health in Children With Inflammatory Bowel Disease
In adults with inflammatory bowel disease (IBD), a higher prevalence of dental caries and periodontal disease has been reported compared with healthy control subjects, but similar data on children are missing in the literature.We…
- Trial name
- NCT05538923
- Testing
- No intervention was given to the patients
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Marmara University
Inflammatory Bowel Diseases, Colitis, Ulcerative
Chronic Care Model on Symptom Status, Stress and Quality of Life in Individuals With Inflammatory Bowel Disease
This study aims to evaluate the effects of nurse counseling provided based on the Chronic Care Model on symptom status, stress, and quality of life in individuals diagnosed with Inflammatory Bowel Disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT06757231
- Testing
- Nurse Counseling Based on the Chronic Care Model (CCM)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Type 1 Diabetes Mellitus, Multiple Sclerosis
T and B Cell Responses in Autoimmune Diseases
The study aims to establish whether defects in immune cell function are shared across multiple autoimmune diseases and whether those problems match to similar genes in the cells.
- Conditions
- Type 1 Diabetes Mellitus, Multiple Sclerosis, Arthritis, Rheumatoid, Crohn's Disease
- Trial name
- SRA01 (NCT01947036)
- Where
- 6 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Inflammatory Diseases
Study of Efavaleukin Alfa in Healthy Chinese, Japanese, and Caucasian Participants
The primary objective of this study is to evaluate the pharmacokinetics (PK) of efavaleukin alfa after single subcutaneous (SC) administration in healthy Chinese, Japanese, and Caucasian participants.
- Trial name
- NCT04987333
- Testing
- Efavaleukin alfa
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amgen
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Inflammatory Bowel Diseases, Ulcerative Colitis
Evaluate Established Anti-DEFA5 mAbs Diagnostic Efficacy and Safety in IBD
Investigators propose to validate efficacy and safety of the detection of DEFA5 in the diagnosis of the colonic IBD using longitudinal vs.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Colitis, Indeterminate Colitis
- Trial name
- NCT05663671
- Testing
- Diagnostic Test
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Ulcerative Colitis, Colon Cancer
Study of Effects of L-Arginine in Colitis and Colon Cancer
The purpose of this study is to look at the importance of L-Arginine in the digestive tract. L-Arginine is an amino acid and is important in making proteins within the cell.
- Trial name
- NCT01091558
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Crohn Disease
Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease
This is a three-arm, non-interventional observational study designed to investigate the relationship between Crohn's disease (CD), the microbiome, and diet in children.
- Trial name
- NCT04283864
- Testing
- endoscopy examination
- Where
- 8 sites in Canada, Croatia and 5 more
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science