Clinical trials: Inflammatory Conditions
Maternal Death, Neonatal Death
Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana
Introduction Maternal and neonatal mortality continue to be to be prominent public health issues in sub Saharan Africa including Ghana, with slow progress made towards attainment of Millennium Development Goals (MDG) 4 \& 5.
- Conditions
- Maternal Death, Neonatal Death, Postpartum Haemorrhage, Pre-eclampsia
- Trial name
- Accelerate (NCT02468310)
- Testing
- Maternal and neonatal emergency protocols
- Where
- Ghana
- Volunteers
- 65,831 people, healthy volunteers welcome
- Sponsor
- Hannah Brown Amoakoh
General Health and Wellness, Energy and Vitality
M4C Nutraceutical Intervention Human Health Effects Pilot
This 3 month pilot study will be an unblinded, convenience sampling, nutraceutical intervention trial. Twenty fasted subjects will undergo a baseline health assessment via a questionnaire, baseline clinical chemistries, blood…
- Conditions
- General Health and Wellness, Energy and Vitality, Cognitive Function and Mental Health, Weight Management
- Trial name
- M4C Pilot (NCT06476236)
- Testing
- M4C
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Concordia University Wisconsin
COVID-19
Study on the Recovery of Pulmonary Function, Chest CT, Airway Microbiota, Hematologic, and Immune & Inflammatory Conditions in COVID-19 Rehabilitation Patients
The intent of this study was to examine the health status of individuals who had been confirmed with COVID-19 in the year after their recovery.
- Trial name
- NCT04456101
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors
The main goals of this study are to provide a cognitive, neurological, brain morphological, and serological profile of sepsis survivors in order to make long-term prognosis of recovery and estimate the need for rehabilitation…
- Trial name
- BonSEP (NCT02339649)
- Testing
- Blood Sample, Neurocognitive Assessment, Resting State EEG
- Where
- 2 sites in Germany
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
ADHD - Attention Deficit Disorder With Hyperactivity
Study of the Nutritional, Inflammatory, and Metabolic Endophenotypes of Attention-Deficit/Hyperactivity Disorder (ADHD)
This study aims to better understand the biological mechanisms involved in attention deficit hyperactivity disorder (ADHD) and to clarify why some children and adolescents respond well to methylphenidate (MPH)-the most commonly…
- Trial name
- ANIME (NCT07417878)
- Testing
- Clinical and Biological Evaluation - ADHD Cases, Clinical and Biological Evaluation - Controls
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Metabolic Syndrome X, Insulin Resistance
Oral Contraceptives in the Metabolic Syndrome
Oral contraceptives (OCs) are the most widely used method of reversible birth control. However, the long-term cardiovascular safety of the widely used low-dose OCs (ethinyl-estradiol < 50 mcg) is still debated.
- Conditions
- Metabolic Syndrome X, Insulin Resistance, Obesity, Cardiovascular Diseases
- Trial name
- NCT00205504
- Testing
- Ortho Tri Cyclen
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Pain, Inflammatory, Pain Management
Reduced-pressure Pneumoperitoneum and Intraperitoneal Saline Washout to Alleviate Pain Following vNOTES Hysterectomy
vNOTES, initially employed for cholecystectomy, appendectomy, and nephrectomy, made its debut in the field of gynecologic surgery in 2012.
- Trial name
- Vnotes (NCT06944015)
- Testing
- normal saline
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Obstructive Sleep Apnea Syndrome
Inflammatory Markers in Infants With Obstructive Sleep Apnea
Obstructive sleep apnea syndrome (OSAS) is a common disorder in children (2-3%). OSAS in turn, is associated with significant behavioral, learning, and heart problems.
- Trial name
- NCT01058590
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Sepsis
Identification Sepsis Related Single Nucleotide Polymorphism (SNP) by Whole Exome Sequencing
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. Single nucleotide polymorphism (SNP) was promising genetic biomarker for sepsis patients.
- Trial name
- NCT01920217
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Preterm, Patent Ductus Arteriosus
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates.
- Conditions
- Preterm, Patent Ductus Arteriosus, Sepsis, Asphyxia
- Trial name
- CE-NeoDoppler (NCT06646250)
- Testing
- NeoDoppler - CE certified
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Late Onset Neonatal Sepsis, Necrotizing Enterocolitis of Newborn
Gut Priming With Oral Bovine Colostrum for Preterm Neonates; Randomized Control Trial
The aim was to assess the ability of bovine colostrum concentrate to reduce the incidence of late-onset sepsis episodes and necrotizing enterocolitis in artificially fed preterm neonates and its effect on T regulatory cells.
- Conditions
- Late Onset Neonatal Sepsis, Necrotizing Enterocolitis of Newborn, Feeding; Difficult, Newborn
- Trial name
- NCT03926390
- Testing
- Bovine colostrum
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acne, Atopic Dermatitis
Collection of Samples From Subjects With Various Skin Conditions and Healthy Volunteers
The purpose of the study is to collect different samples for molecular characterization of inflammatory skin diseases.
- Conditions
- Acne, Atopic Dermatitis, Chronic Hand Eczema, Hidradenitis Suppurativa
- Trial name
- NCT05994976
- Testing
- Blood samples collection, Oral samples collection, Hair samples collection
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.
"Exposure to Heat"
The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response
There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress.
- Trial name
- NCT00808925
- Testing
- exposure to heat
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Prof. Yoram Epstein
Sepsis
Detection of Sepsis Occurrence by Using Blood Fluorescence
This study adopted a case-control study method to explore a reagent-free, highly sensitive, and frequently screened blood fluorescence metabolite analyzer for sepsis, which can detect the emergence of inflammatory free radicals…
- Trial name
- NCT06745115
- Testing
- Blood fluorescence metabolite analyzer
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Inflammation, Atherosclerosis
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
Polyphenol supplements, including curcumin and resveratrol, are known to decrease inflammation, but previous polyphenol supplements were poorly absorbed and thus their effects were reduced.
- Conditions
- Inflammation, Atherosclerosis, Cardiovascular Disease
- Trial name
- PSI (NCT02998918)
- Testing
- PolyResveratrol Supplementation, Curcumin Supplementation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Chronic Pain, Inflammatory Response
The Effect of Chiropractic Plus Nutritional Supplement in Patients With Chronic Pain and Inflammation.
Evaluating the effect of a combined therapy of chiropractic sessions plus nutritional supplement containing hemp, omega-3 fatty acids, and broccoli extract oil in patients experiencing chronic pain and inflammation.
- Trial name
- NCT05743855
- Testing
- Nutritional Supplement
- Where
- 3 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
Inflammatory Response, Inflammation
Fat Quality and Postprandial Inflammation
This aim of this randomized controlled postprandial study is to compare the effects of four different far sources (butter, coconut, corn oil and flax seed oil) on postprandial inflammation and metabolic response.
- Trial name
- PI:fat (NCT05674708)
- Testing
- Fat intake
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Crohn's Disease
COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk)
The cause of CD could be different according to age at onset of CD symptoms. Indeed we know that some very young patients at CD diagnosis have particular genetic variants as abnormalities of the IL10R that are regarded as quite…
- Trial name
- COMeBACk (NCT02839317)
- Testing
- Biological
- Where
- 5 sites in France
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Healthy, Obesity
Postprandial Inflammatory Response in Healthy Men: Effect of Dietary Fat Source, Obesity and Age
The nature of dietary lipids, age and perivisceral adiposity could alter the postprandial inflammatory response. It is supposed that there is a relationship between the postprandial inflammatory response and the repartition of…
- Trial name
- NCT01066091
- Testing
- Mashed potatoes, Mashed potatoes + Oleic acid, mashed potatoes + Palmitic acid
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yves Boirie
Sexual Dysfunction, Endothelial Dysfunction
Effects of Lifestyle-modification Induced Weight Loss on Sexual and Urinary Function, and Quality of Life in Obese Men
This study aims to evaluate the extent to which weight loss of 5-10% from baseline, induced by exercise and diet, improves metabolic and inflammatory profile, endothelial function, erectile function, sexual desire, lower urinary…
- Conditions
- Sexual Dysfunction, Endothelial Dysfunction, Quality of Life, Inflammation
- Trial name
- NCT01554735
- Testing
- Exercise and diet
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
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