Clinical trials: Inflammatory Conditions
Sepsis
Defining Circulating Micro-RNA Biomarkers for the Early Diagnosis and Prognosis of Sepsis
The objectives are to: 1. derive and validate a panel of miRNAs that are consistently differentially expressed in the plasma of patients with and without sepsis 2.
- Trial name
- miRNA-Sepsis (NCT02544490)
- Where
- Singapore
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Inflammation
Inflammatory Responses to Acute and Chronic Opioid Exposure in Humans
We aim to examine the extent to which inflammation is affected by acute and chronic opioid exposure.
- Trial name
- NCT01749826
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Reproductive Health
Anti-Inflammatory Diet and Physical Activity for Reproductive Health in Adolescent Girls
This study will evaluate whether a 16-week anti-inflammatory dietary intervention, delivered alone or together with a physical activity programme, can improve diet quality and support reproductive health in girls aged 14-19…
- Trial name
- 4fertil (NCT07834489)
- Testing
- Anti-Inflammatory Dietary Intervention, Physical Activity and Training Programme
- Where
- 2 sites in Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Multiple Trauma
Danger Response in Polytrauma Patients
The NTF_PT_2014 multicenter study aims to collect, store, and analyse plasma and serum from polytrauma-patients (injury severity score ≥25) and corresponding clinical data to address 1) how trauma modulates the release of danger…
- Trial name
- NTF-PT (NCT02682550)
- Testing
- blood drawing
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Arteriosclerosis, Myocardial Infarction
Alcohol, Inflammation and Atherosclerosis
Effect of moderate alcohol consumption in form of red wine, beer and ethanol solution and corresponding de-alcoholised beverages on immune measures.
- Trial name
- NCT00764426
- Testing
- red wine, beer, ethanol, de-alcoholised red wine, de-alcoholised beer, water
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- European Research Advisory Board
Sepsis, Oxidative Stress
Sepsis and Thiol-Disulfide Balance in Emergency Department
The aim of this study was to determine the effectiveness of thiol-disulfide homeostasis in predicting diagnosis and mortality in sepsis patients, and to compare it with other inflammatory markers.
- Trial name
- NCT07134868
- Testing
- Thiol- Disulfide Blood Sample Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Sepsis
Effect of Renin-Angiotensin System on Platelet in Patient With Sepsis
As a common and serious medical condition , sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection , which is a major and familiar cause of death in intensive care units(ICU).
- Trial name
- ERASPPWS (NCT03952390)
- Testing
- control, sepsis
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Obstructive Sleep Apnea
Obstructive Sleep Apnea in the Absence of Metabolic Syndrome
Obstructive Sleep Apnea (OSA) is commonly associated with factors that increase cardiovascular risk, including Metabolic Syndrome (MS).
- Trial name
- NCT01635010
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Medical Knowledge, Clinical Performance
Utility of High-Fidelity Simulation In the Education and Assessment of Residents in the Recognition and Management of the Sepsis Syndrome
The primary objective of the proposed study will be to determine if a multi-modality teaching curriculum utilizing high-fidelity simulation and didactic lecture will result in sustained improvement by internal medicine residents…
- Trial name
- NCT01992120
- Testing
- Debriefing of high-fidelity sepsis simulation scenarios
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Acute Kidney Failure With or Without:, MODS
Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT
1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been established in a formal paper.
- Conditions
- Acute Kidney Failure With or Without:, MODS, Sepsis, Hepatic Insufficiency
- Trial name
- NCT00948558
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Atrial Fibrillation, Sepsis
Continuous Ambulatory Cardiac Monitoring for Recurrent Atrial Fibrillation After Sepsis
To detect atrial fibrillation after infection.
- Conditions
- Atrial Fibrillation, Sepsis, Infections, Cardiac Arrhythmia
- Trial name
- CAMS-AF (NCT05217485)
- Testing
- Zio 14-day cardiac patch
- Where
- United Kingdom
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Overweight, Diabetes
Effect of Nutritional Interventions on Inflammatory Status in Healthy Overweight Men
In the present study it is hypothesized that a reduction of the inflammatory status may prevent the occurrence of disorders and diseases related to overweight.
- Conditions
- Overweight, Diabetes, Cardiovascular Disease
- Trial name
- NCT00655798
- Testing
- Plain Yogurt + mix of anti-oxidants capsules, Yogurt containing Lactobacillus helveticus, Yogurt containing Bifidobacterium animalis ssp.
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- TNO
Overweight and Obesity, Exertion; Excess
Effects of Ketogenic Diet in Divers Breathing Enriched Air Nitrox
Overweight divers face a challenging activity such as immersions, starting from a higher levels of circulating cytokines and oxidative stress.
- Conditions
- Overweight and Obesity, Exertion; Excess, Oxygen Toxicity
- Trial name
- NCT03114176
- Testing
- Ketogenic Diet
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Padova
Neonatal SEPSIS, Nosocomially Acquired Neonatal Sepsis
A Study on Ventilator-associated Pneumonia as a Risk for Nosocomial Infection in Mechanically Ventilated Neonates In NICU of Assiut University Children Hospital (Nicu Eta)
Abstract Background: Neonatal ventilator associated pneumonia (VAP) is a major hospital-acquired infection in acute care settings, associated with high mortality and poor outcome.
- Trial name
- nicu eta (NCT03310840)
- Testing
- others
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypothermia
Plastic Hat Trial to Prevent Hypothermia in Preterm Newborns in the Delivery Room
The purpose of this research project is to ascertain the effectiveness of plastic head covering in prevention of hypothermia. Hypothermia is defined by body temperature <36.5º Celsius by the World Health Organization.
- Trial name
- NCT00904228
- Testing
- placement of plastic cap during delivery room stabilization, placement of routine cap during delivery room stabilization
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Septic Shock
Glycosaminoglycans During Septic Shock - a Temporal Study
We have previously shown that the plasma level of glycosaminoglycans (GAG) in septic shock patients are elevated compared to controls.
- Trial name
- GAGS (NCT00814112)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Region Skane
Colorectal Cancer, Diet, Healthy
Chemerin in Colorectal Cancer and Its Relationship With Diet Quality
To investigate the relationship between serum chemerin levels of individuals with colorectal cancer and systematic inflammatory response parameters such as C-reactive protein(CRP) and albumin, and to investigate the relationship…
- Conditions
- Colorectal Cancer, Diet, Healthy, Diet Habit, Nutrition Aspect of Cancer
- Trial name
- NCT06018077
- Testing
- Dietary İntake, Biochemical parameters, Antropometric measuruments
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Exercise Recovery, Exercise-induced Muscle Damage
Effect of Cordyceps Supplementation Timing on Physiological Responses and Aerobic Adaptation in Athletes
Athletes frequently perform high-intensity exercise to improve physical performance and aerobic capacity. However, such training can induce exercise-induced muscle damage, oxidative stress, and inflammatory responses that may…
- Conditions
- Exercise Recovery, Exercise-induced Muscle Damage, Oxidative Stress, Sports Performance
- Trial name
- CORD-RECOV (NCT07664345)
- Testing
- Pre-Exercise Cordyceps Sinensis, Post-Exercise Cordyceps Sinensis
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Surabaya State University
Overweight and Obesity, Inflammation; Muscle
Influence of Aerobic Training and Weight Loss on Skeletal Muscle Inflammatory Markers and Muscle Protein Balance in Older Adults
It is estimated that 15% of adults aged 60-70 years, and up to 50% of adults aged 80 years and older are affected by sarcopenia-the age related loss of muscle mass and function.
- Conditions
- Overweight and Obesity, Inflammation; Muscle, Sedentary Lifestyle
- Trial name
- NCT03743675
- Testing
- Diet-Induced Weight Loss, Aerobic Exercise Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Miami University
Systemic Inflammatory Response Syndrome
Conventional Ultrafiltration Versus Dilutional Ultrafiltration in Pediatric CPB Patients
The investigators will be comparing two different filtration methods on cardiopulmonary bypass for pediatric heart surgery patients.
- Trial name
- NCT07221630
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akron Children's Hospital
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