Clinical trials: Inflammatory Disorder
Lung Diseases
Analysis of Anti-inflammatory and Antioxidant Pathways in Lung Diseases by Haem Oxygenase-1 (HO-1) in Induced Sputum and Carbon Monoxide (CO) in Exhaled Air
This work will focus on the anti-inflammatory and antioxidant pathways in lung diseases by measuring HO-1 in induced sputum and CO in exhaled air in cases of four respiratory diseases, asthma, chronic obstructive pulmonary…
- Trial name
- NCT01140685
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Klinefelter Syndrome, Hypogonadism
Epigenetics and Metabolic Disorders in Men With the Klinefelter Syndrome
This study will elucidate how the parental origin of the X-chromosome influences health status as well as metabolic fate in Klinefelter patients.
- Trial name
- IZKF-CRA03-09 (NCT01703676)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Psoriasis
A Safety/Efficacy Study of a Non-steroid, Topical Cream Treatment of Psoriasis Over 12-weeks
Psoriasis is a chronic inflammatory skin disorder that is characterized by hyperproliferation of the keratinocytes and inflammation of the epidermal and dermal layers of the skin.
- Trial name
- 134993 (NCT01098721)
- Testing
- WBI-1001
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Welichem Biotech Inc.
Bacteraemia Post Debridement
PVP Iodine Effect on Post Debridement Bacteraemia
The study investigates the effect of supra- and subgingival rinsing of 10% PVP prior to ultrasonic debridement in patients with periodontitis (as compared to rinsing with water) in terms of post treatment bacteraemia.
- Trial name
- PJB 1 (NCT01647347)
- Testing
- Supra- and subgingival rinsing with 10% PVP-iodine, Water
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pelvic Inflammatory Disease
Pelvic Inflammatory Disease in COVID-19 Era
The goal of this retrospective cohort study is to to scrutinize the impact of coronavirus disease 2019 (COVID-19) on incidence, demography and patient characteristics in Pelvic Inflammatory Disease comparing with the equal time…
- Trial name
- NCT05648747
- Testing
- impact of COVID-19 on Health-Seeking Behaviors
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Ferrara
Neonatal SEPSIS
Neonatal Sepsis at Neonatal Intensive Care Units in Ghana
Background: Neonatal sepsis is a major contributor to global under five mortality. In developing countries a major proportion of neonatal sepsis is thought to emanate from the healthcare setting, due to challenges in infection…
- Trial name
- NCT03755635
- Testing
- The WHO multimodal hand hygiene strategy
- Where
- Ghana
- Volunteers
- 5,433 people, healthy volunteers welcome
- Sponsor
- Stephanie Bjerrum
Sepsis
Effect of Lipopolysaccharide on Skeletal Muscle Functions
The investigators aim to examine how the skeletal muscles of the human volunteers respond to experimental septic conditions to aid understanding of muscle wasting and its biology..
- Trial name
- LPS (NCT01423968)
- Testing
- Lipopolysaccharide infusion, saline
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Septic Shock, Calcium Sensing Receptor
Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock
In septic shock, bacterial LPS is able to activate the CaSR of cardiomyocytes inducing their apoptosis in vitro. CaSR activation in monocytes is responsible for activation of the NLRP3 inflammasome and macropinocytosis.
- Conditions
- Septic Shock, Calcium Sensing Receptor, Calcium Phosphate Disorders, Inflammation
- Trial name
- CASRCHOC (NCT06853340)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Exercise Myoglobinuria, Citrulline; Metabolic Disorder
Supplementation With Altha-aminoacids and Systemiec Inflammatory Response in Long-distance Runners.
It is also noteworthy that the imbalance between the production, supply and elimination of especially α-amino acids may contribute to the intensification of the inflammatory response and the subsequent burden of the renal…
- Conditions
- Exercise Myoglobinuria, Citrulline; Metabolic Disorder, Iron Metabolism Disorders, Inflammatory Response
- Trial name
- NCT05510440
- Testing
- Alpha-amino acid derivatives
- Where
- 2 sites in Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Inflammatory Bowel Disease
Study to Observe the Change in Microbiome in Human Derived Sample and the Relation With Clinical Response Before and After the Anti-TNF Treatment in IBD Patients
This study will be conducted to observe the difference in microbiome composition between healthy participants and inflammatory bowel disease (IBD) participants with no anti-tumor necrosis factor (anti-TNF) treatment.
- Trial name
- ETERNITY (NCT03264690)
- Where
- 3 sites in South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eisai Korea Inc.
Obesity, Chronic Inflammation
Impact of Gut Hormones and Inflammatory Adipokines in Obese Patients Underwent Bariatric Surgery
Obesity and type 2 diabetes, dyslipidemia and related metabolic disease has become a threat to our national life and health which is showing a trend.
- Conditions
- Obesity, Chronic Inflammation, Type 2 Diabetes
- Trial name
- NCT02963662
- Testing
- laparoscopic Roux-en-Y gastric bypass, laparoscopic sleeve gastrectomy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gao Zhiguang
Crohn's Disease, Vitamin D Deficiency
Exploring the Effects of Vitamin D Supplementation on the Chronic Course of Patients With Crohn's Disease With Vitamin D Deficiency
Aims:Prospectively observe the effects of Vitamin D drops supplementation on the chronic course of Crohn's disease patients, analyze whether the effect of Vitamin D drops on CD patients is affected by factors such as disease…
- Conditions
- Crohn's Disease, Vitamin D Deficiency, Vitamin D Supplement
- Trial name
- NCT04308850
- Testing
- Vitamin D drops
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sepsis, Severe Sepsis and Septic Shock
Evaluation of CPD MNV as an Aid in the Diagnosis and Risk Assessment of Sepsis (Protocol # Sepsis 1-14)
The investigators hypothesize that CPD parameters will provide improved prediction of sepsis compared to currently employed laboratory parameters.
- Trial name
- Beckman (NCT02232750)
- Where
- United States
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Inflammatory Disease, Autoimmune Diseases
A Dose Escalating Study of HC002 in Healthy Adult Volunteers
This is a first-in-human (FIH) study to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending oral doses of HC002 in healthy adult participants.
- Trial name
- NCT06670274
- Testing
- HC002 SAD, HC002 MAD
- Where
- Australia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Holoclara Aus Pty Ltd
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Stroke, Thrombectomy
ENDOTHELIAL GLYCOCALYX AND INFLAMMATORY RESPONSE CHANGES IN PATIENTS WITH ACUTE STROKE UNDERGOING MECHANICAL THROMBECTOMY
Ischemic stroke (IS) is one of the leading causes of mortality and disability. Treatment of IS is based on reperfusion methods, thrombolysis and mechanical thrombectomy (MT).
- Conditions
- Stroke, Thrombectomy, Endothelial Glycocalyx
- Trial name
- DEGIMT (NCT07292974)
- Testing
- Mechanical thrombectomy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Centre Zagreb
Inflammation In Skeletal Muscle
Natural History of Inflammatory Muscle Diseases
Objective: To collect information and biospecimens (such as blood, muscle, and skin samples) that will be used to research causes and treatments of inflammatory muscle diseases.
- Trial name
- NCT05738824
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Colonic Polyps, Cancer Colon
Evaluation of Reduced-volume PEG Bowel Preparation Administered the Same Day of Colonoscopy
The conventional total dose of 4 L of polyethylene glycol (PEG) given the day before the procedure is safe and effective. It has been the standard cleansing regimen for the last 25 years.
- Conditions
- Colonic Polyps, Cancer Colon, Inflammatory Bowel Disease
- Trial name
- LowVolumePEG (NCT01533090)
- Testing
- polyethylene glycol (PEG), PEG low volume with bisacodyl
- Where
- Italy
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Muscle Protein Synthesis, Endotoxemia
Whey vs Casein to Combat Post-inflammatory Protein and Muscle Waste in Acute Disease
This study compares three different protein supplements (casein, whey and leucine-enriched whey) and their effect on post-inflammatory muscle waste in a model of acute disease.
- Conditions
- Muscle Protein Synthesis, Endotoxemia, Nutrition, Milk Protein
- Trial name
- NCT03319550
- Testing
- Casein, Whey, Leucine-enriched whey
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cystic Fibrosis
Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers
Inflammation clearly contributes to the progression of the cystic fibrosis (CF) lung disease, and administration of the anti-inflammatory agent high-dose ibuprofen retards the rate of decline of pulmonary function.
- Trial name
- NCT00531882
- Testing
- Pioglitazone, Simvastatin, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
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