Clinical trials: Inflammatory Disorder
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06320314
- Testing
- tested product (2039125 03)
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Chronic Inflammatory Demyelinating Polyneuropathy
A Registered Cohort Study of Immune-Mediated Neuropathies
This study will provide further insights into the natural course of the disease about Immune-Mediated Neuropathies including clinical features，progression, related antibody spectrum and drug treatment effect.
- Trial name
- NCT04292834
- Where
- 2 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Inflammatory Bowel Diseases
Predictors of Subclinical Atherosclerotic Cardiovascular Diseases (ASCVD) in Patients With Inflammatory Bowel Disease
Heart disease and failure are the major causes of mortality and morbidity worldwide, despite significant advances in medical technologies in the diagnosis and treatment of the disease.
- Trial name
- NCT03868332
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Plaque Induced Gingivitis, Mouth Diseases
Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide
The goal of this clinical trial is to test efficiency of using mouth rinse containing (H2O2 and HA) over a period of two weeks to control on gingival inflammation and plaque accumulation through measuring the clinical periodontal…
- Conditions
- Plaque Induced Gingivitis, Mouth Diseases, Bleeding Gum, Periodontal Diseases
- Trial name
- NCT05787600
- Testing
- Perhyal rinse, Chlorhexidine mouthwash
- Where
- Iraq
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Psoriasis
Study on the Therapeutic Mechanisms of Dithranol Treatment in Patients With Chronic Plaque Psoriasis
Dithranol (known in the U.S.A. as anthralin and in Germany as cignolin) is one of the oldest and safest topical anti-psoriatic treatments.
- Trial name
- NCT02752672
- Where
- Austria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Inflammatory Bowel Disease, Crohn Disease
Pneumococcal Vaccination in Patients With Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) will be assessed for immunologic response to pneumococcal vaccination. Patients with IBD meet criteria as outlined by the Centers for Disease Control (CDC) for pneumococcal…
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT00829595
- Testing
- 23-valent polysaccharide pneumococcal vaccine (Pneumovax TM)
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA)
Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases
The goal of this clinical trial is to evaluate whether the live attenuated tetravalent Butantan-Dengue vaccine (Butantan-DV) is safe and capable of inducing an immune response in patients aged 12 to 59 years with autoimmune…
- Conditions
- Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA), Systemic Lupus Erythematosus (SLE), Juvenile Systemic Lupus Erythematosus
- Trial name
- BTNDV-ARD (NCT07087912)
- Testing
- Dengue 1,2,3,4 (attenuated) vaccine
- Where
- 2 sites in Brazil
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Periodontal Diseases
Impact of Full Mouth Erythritol Powder Air Polishing on Systemic Inflammatory Response
Periodontitis (PD) is an inflammatory condition that affects 20%-50% of the total global population, with severe disease occurring in 9.8% of individuals.
- Trial name
- NCT05812391
- Testing
- test, conventional
- Where
- Iraq
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Anhedonia, Depression
A Neurobiological Model of Anhedonia
The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.
- Trial name
- NCT05629520
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Healthy, Obese
Early Effect of Fasting on Metabolic, Inflammatory, and Behavioral Responses in Females With and Without Obesity
The aim of this study is to investigate the effect of overnight fasting versus a diurnal fasting (during daily life activities) in females with and without obesity on inflammation, neurotrophins, energy metabolism, mood, food…
- Trial name
- NCT03532672
- Testing
- Acute Fasting
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Sepsis, Length of Stay
Limited Versus Extended Trophic Feeding (LET-FEED) Trial
Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis…
- Conditions
- Sepsis, Length of Stay, Mortality, Neurodevelopmental Delay
- Trial name
- LET-FEED (NCT06893939)
- Testing
- Limited Trophic Feeds (1 day of trophic feeds), Extended Trophic Feeds (3 days of trophics)
- Where
- 6 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Washington
Immunity, Vaccine Reaction
Efficacy and Tolerability of ABBC1 in Volunteers Receiving the Influenza or Covid-19 Vaccine
The immune system response needs to be forceful but also balanced for a rapid recovery from infection which avoids harmful overreactions.
- Conditions
- Immunity, Vaccine Reaction, Influenza, Covid19
- Trial name
- NCT04798677
- Testing
- ABBC1 Immunoessential
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AB Biotek
Ulcerative Colitis (UC), Crohn's Diseases
Cardiovascular Risk in Patients With IBD
In this study the Research Hospital San Donato Policlinic ask the participation with the aim to evaluate the risk of cardiovascular complication (i.e. stroke, myocardial infarction) in patients with inflammatory bowel disease.
- Conditions
- Ulcerative Colitis (UC), Crohn's Diseases, Cardiovascular Risk
- Trial name
- DICOM-IBD (NCT07663201)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Patients With Systemic Inflammatory Diseases Receiving for the First Time a Protracted General Corticostroid Therapy
Impact of Systemic Corticosteroid Therapy on Lens Transparency and Quantification of Lens Autofluorescence.
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking.
- Trial name
- NCT00337623
- Testing
- Prednisolone
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Upper Respiratory Tract Infections
Probiotic Trial for URTI Prevention in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial in generally healthy adults aged 18-65 years will compare the incidence of upper respiratory tract infections (URTIs) over 16 weeks between probiotic supplement and…
- Trial name
- NCT07908797
- Testing
- Probiotic Formula
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Childhood Obesity, Life Style
Dietary Habits and Sleep in Childhood Obesity
Recruitment of obese children, classification according to sleep questionnaire and randomization in two groups to perform nutritional and sleep intervention. . One group receives dietary intervention through recommendations.
- Conditions
- Childhood Obesity, Life Style, Circadian Rhythms
- Trial name
- INFOB (NCT03764579)
- Testing
- sleep and diet intervention vs diet intervention
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD)
Familial Inflammatory Bowel Disease Early Risk
Brief Summary The aim of the FIBER study is to identify potential triggers associated with the later development of IBD (inflammatory bowel disease) based on baseline characteristics and biosamples (blood, urine, stool, saliva…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- FIBER (NCT07791862)
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Gingivitis
Variation in Gingival Inflammatory Responses
The aim of this NIH National Institute of Dental and Craniofacial Research (NIDCR) funded study is to identify molecular mechanisms underlying observed variations in human responses to natural accumulation and maturation of…
- Trial name
- NCT05968742
- Testing
- Abstinence of oral hygiene on select teeth
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pelvic Inflammatory Disease, Chlamydia Infections
Community-Based Trial of Screening for Chlamydia Trachomatis to Prevent Pelvic Inflammatory Disease
Chlamydial infection is a common, sexually transmitted disease which women can have without knowing. Untreated, it can lead to an infection of the womb and fallopian tubes called pelvic inflammatory disease (PID), which can cause…
- Trial name
- POPI (NCT00115388)
- Testing
- Screening for chlamydia using self-taken vaginal swabs
- Where
- United Kingdom
- Volunteers
- 2,531 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
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