Clinical trials: Inflammatory Disorder
Idiopathic Inflammatory Myopathy
A Case-control Study to Assess Risk of Coronary Heart Disease in Idiopathic Inflammatory Myopathy
This study will be co-ordinated by Dr Hector Chinoy, Dr Robert G Cooper (Salford Royal NHS Foundation Trust / The University of Manchester) and Dr Ian N Bruce (Central Manchester University Hospitals NHS Foundation Trust/ The…
- Trial name
- NCT00971828
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northern Care Alliance NHS Foundation Trust
Asthma
Prednisolone Pharmacokinetics in Severe Asthma
The purpose of the study is to evaluate whether severe asthmatic subjects have abnormal prednisolone absorption, and how this might affect the anti-inflammatory effects of prednisolone. The aims of the study are 1.
- Trial name
- NCT00662298
- Testing
- prednisolone
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Psoriasis
A Safety/Efficacy Study of a Non-steroid, Topical Cream Treatment of Psoriasis Over 12-weeks
Psoriasis is a chronic inflammatory skin disorder that is characterized by hyperproliferation of the keratinocytes and inflammation of the epidermal and dermal layers of the skin.
- Trial name
- 134993 (NCT01098721)
- Testing
- WBI-1001
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Welichem Biotech Inc.
Ulcerative Colitis (UC), Crohn Disease (CD)
Effect of Isoflavone and Vitamin D Supplementation on Serum Vitamin D Levels, Body Composition, Inflammatory Markers, and Quality of Life in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by recurrent intestinal inflammation, impaired nutritional status, and reduced quality of life.
- Trial name
- NCT07656233
- Testing
- Standard medical treatment, Tempeh Isoflavone, Vitamin D (Cholecalciferol )
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome
Anti-CD19-CD3E-CAR-T Cells in Relapsed/Refractory Autoimmune Disease
This is an investigator-initiated trial to evaluate the safety and efficacy of anti-CD19-CD3E-CAR-T cells in the relapse or refractory autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome, Systemic Sclerosis, Inflammatory Myopathy
- Trial name
- NCT06373081
- Testing
- Anti-CD19-CD3E-CAR-T cells
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shanghai Changzheng Hospital
Inflammatory Arthritis, Rheumatoid Arthritis
The CCP Study: Coordinated Programme to Prevent Arthritis - Can We Identify Arthritis at a Pre-clinical Stage ?
This is a 12-month, prospective, observational cohort trial involving Primary Care Trusts (PCTs) wishing to take part in the study and the Early Arthritis Clinic (Anti-CCP sub-clinic) at Chapel Allerton Hospital.
- Trial name
- CCP (NCT02012764)
- Where
- United Kingdom
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Sepsis of the Newborn
Role of 'Pentoxifylline and or IgM Enriched Intravenous Immunoglobulin in the Treatment of Neonatal Sepsis'
The investigators aim is to investigate whether adjuvant Pentoxifylline , IgM enriched IVIG or Pentoxifylline plus IgM-enriched IVIG reduced mortality from Neonatal sepsis.
- Trial name
- NCT01006499
- Testing
- Pentoxifylline, pentaglobin
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Chronic Obstructive Pulmonary Disease, Diastolic Dysfunction
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD
This is a prospective study to determine the relationships between pauci-inflammatory exacerbations and diastolic dysfunction, and their implications in hospitalized patients with acute exacerbations of COPD.
- Trial name
- NCT03110614
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Alabama at Birmingham
Avascular Necrosis of Hip, Osteoarthritis, Hip
Allofit® IT Ceramic Bearing System in Total Hip Arthroplasty
This is a multi-center, prospective, non-controlled post market surveillance study. The objectives of this study are to obtain survival and outcome data on the Allofit IT Shell in combination with the BIOLOX® delta Taper Liner…
- Conditions
- Avascular Necrosis of Hip, Osteoarthritis, Hip, Inflammatory Arthritis, Post-Traumatic Osteoarthritis of Hip
- Trial name
- NCT03672916
- Where
- 4 sites in Germany, Sweden
- Volunteers
- 185 people
- Sponsor
- Zimmer Biomet
Fetal Membranes, Premature Rupture, Premature Birth
The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Cranberries have been proved to reduce the rate of urinary tract infections in a population of women with recurrent urinary tract infections in previous studies.
- Trial name
- NCT00247104
- Testing
- Cranberries - Vaccinium macrocarpon
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Heart Failure, Cardiac Cachexia
Enteral Nutrition in Congestive Heart Failure and Cardiac Cachexia
The purpose of this study was to determine the effects of a high caloric drink on weight and several other clinical markers including quality of life in patients with unintentional weight loss (cachexia) due to chronic heart…
- Trial name
- NCT00654719
- Testing
- NutriDrink
- Where
- 2 sites in Germany, Poland
- Volunteers
- 29 people
- Sponsor
- National Heart and Lung Institute
Scars, Delayed Wound Healing
Nanofat on Wound Healing and Scar Formation
This study will evaluate the effectiveness and safety of intradermal injection of Nanofat on wound healing and scar formation.
- Conditions
- Scars, Delayed Wound Healing, Hypertrophic Scar, Post Inflammatory Hyperpigmentation
- Trial name
- NFWHSF (NCT03850119)
- Testing
- Nanofat injection
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Pulmonary Hypertension
Inflammatory Profiling in Chronic Lung Disease
The aim of this study is to investigate the underlying inflammatory profile in patients with chronic lung disease and determine the association pulmonary hypertension.
- Trial name
- NCT04654767
- Testing
- Tissue sampling
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Ludwig Boltzmann Institute for Lung Vascular Research
Psoriatic Arthritis, Psoriasis
Pain Mechanisms and Ultrasonographic Disease Activity in Psoriatic Arthritis
The objective of the study is to investigate pain mechanisms, comorbidity status, biomarkers, patient reported outcome measures, ultrasonographic (US) inflammatory activity and association between these features in patients with…
- Conditions
- Psoriatic Arthritis, Psoriasis, Healthy Controls
- Trial name
- PIPA (NCT02572700)
- Testing
- Clinical examination, blood sampling, ultrasonic assessment, and questionnaires
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Parasite IBS IBD
Role of Parasitic Infection in Inflammatory Bowel Disease and Irritable Bowel Syndrome
Role of parasitic infection in Inflammatory bowel disease and Irritable bowel The burden of the parasitic disease is in-direct relation with the health and nutritional status of the host, inducing not only parasite-specific…
- Trial name
- NCT04760600
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Systemic Inflammatory Response Syndrome (SIRS)
Effect of Lactiplantibacillus Plantarum DAD-13 on Inflammatory Markers in ICU Sepsis Patients
This study investigated whether giving the probiotic Lactiplantibacillus plantarum DAD-13 to sepsis patients in the intensive care unit (ICU) could help reduce inflammation and improve bowel function.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- LactoSepsis (NCT07072871)
- Testing
- Lactiplantibacillus plantarum DAD-13
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- PT Royal Medikalink Pharmalab
Colo-rectal Cancer, Crohn Disease
Anastomotic Leakage and Value Of Indocyanine Green in Decreasing Leakage Rates
Anastomotic leakage (AL) is one of the major complications after gastrointestinal surgery. Compromised tissue perfusion at the anastomosis site increases the risk of AL.
- Conditions
- Colo-rectal Cancer, Crohn Disease, Resectable Colorectal Carcinoma
- Trial name
- AVOID (NCT04712032)
- Testing
- ICG-guided bowel perfusion assessment
- Where
- Netherlands
- Volunteers
- 978 people
- Sponsor
- Leiden University Medical Center
Cardiomyopathies
Magnetocardiography as a Diagnostic Screening Tool for Myocarditis and Other Types of Cardiomyopathy
Accurate and rapid screening is an unmet medical need to address the increasing demand for advanced diagnostic workup in patients with suspected cardiomyopathy.
- Trial name
- MagMa (NCT06689098)
- Testing
- Magnetocardiography scan
- Where
- Germany
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- German Heart Institute
Acute Cholecystitis
Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder?
During the laparoscopic cholecystectomy for acute cholecystitis, most surgeons routinely use the postoperative antibiotics after surgery.
- Trial name
- NCT02490293
- Testing
- Cephalosporin
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Taeho Hong
Supraventricular Arrhythmia, Septic Shock
Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial
New-onset supraventricular arrhythmia (NOSVA) is reported in 40 % of patients with septic shock and is associated with hemodynamic alterations and mortality.
- Trial name
- CAFS (NCT04844801)
- Testing
- Risk control strategy, Heart-Rate control strategy:, Rhythm control strategy:
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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