Clinical trials: Inflammatory Marker
Neonatal Sepsis
Role of Presepsin as a Novel Biomarker in Diagnosis of Neonatal Sepsis
-Introduction: Sepsis is a clinical syndrome that results from a deregulated inflammatory response to an infection. it is life-threatening entity causing millions of deaths worldwide, with variable clinical manifestations and…
- Trial name
- NCT06633770
- Testing
- proclcitonin and presepsin
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Colitis
Syndecan 1 as Biomarker for Inflammation
The aim of the study is to evaluate the soluble biomarker syndecan-1 (sSdc1) taken from venous blood of patients with infectious intestinal diseases such as Clostridium difficile-associated colitis, bacterial colitis, Norovirus…
- Trial name
- NCT02333526
- Where
- 2 sites in Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Helios Albert-Schweitzer-Klinik Northeim
Diet Modification, Physical Activity
Denver Garden Environment and Microbiome Study Disease
An interdisciplinary team with extensive garden study experience conducted a pilot randomized controlled clinical trial to see whether gardening reduced risk factors for diseases like cancer and heart disease.
- Conditions
- Diet Modification, Physical Activity, Weight Gain, Chronic Disease
- Trial name
- DGEM (NCT03089151)
- Testing
- Community Garden Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Sepsis, Septic Shock
We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury.
The investigators selected patients diagnosed with sepsis who were admitted to the Intensive Care Unit (ICU) of Huai'an First People's Hospital between June 2022 and December 2023, as well as healthy individuals with normal…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- ELABELA（ELA） (NCT06001294)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xiangcheng Zhang
Major Depressive Disorder
Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder
The purpose of this study is to determine if translocator protein total distribution volume (TSPO VT) is elevated in major depressive disorder that is not responding to medication and if adding minocycline can affect TSPO VT.
- Trial name
- NCT02362529
- Testing
- Minocycline, Celecoxib
- Where
- Canada
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Endothelial Function, Oxidative Stress
Black Forest Cocoa Flavanol Supplementation and Health Trial
This randomized, double-blind, controlled clinical trial will evaluate the effects of daily cocoa flavanol supplementation on vascular and inflammatory biomarkers in healthy adult men aged 30 to 75 years.
- Conditions
- Endothelial Function, Oxidative Stress, Inflamation, Vascular Health
- Trial name
- NCT07747714
- Testing
- Cocoa Flavanol Supplement, Low-Flavanol Control Powder
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Black Forest LLC
Inflammatory Bowel Disease (IBD)
Diagnosis of Inflammatory Bowel Disease
To quantify the expression of Nuclear enriched abundant transcript 1 (NEAT1) and Anti-sense Non RNA in the INLK4 locus (ANRIL) to determine their potential role as non invasive diagnostic biomarkers in inflammatory bowel disease.
- Trial name
- NCT07400211
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy
Investigation of the Postprandial Response of Two Different PDO Cheeses on Metabolic Biomarkers
The purpose of this study was the investigation of the postprandial metabolic responses, after the intake of a traditional, Ladotyri Mytilinis cheese, compared to corresponding responses after an Italian Parmesan cheese…
- Trial name
- LadotyriCT (NCT05788887)
- Testing
- Authentic Ladotyri Mytilinis PDO cheese, Control
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of the Aegean
Insulin Resistance, Inflammatory Markers
Effectiveness of Low Level Laser Therapy on Insulin Resistance and Inflammatory Biomarkers
It is an interventional study in which 60 women estimated to enroll according to random allocation and assigned into two groups equal.
- Trial name
- NCT04477109
- Testing
- low level laser in addition to diet recommendations
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vaginal Inflammation, Vaginal Infections
Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation
This study investigates the response of vaginal and cervical tissue after exposure to three vaginal products: hydroxyethyl cellulose (HEC) placebo, nonoxynol-9 (N9) and imiquimod (IMQ) cream.
- Trial name
- Biomarkers (NCT01593124)
- Testing
- Imiquimod, Nonoxynol-9
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CONRAD
Bipolar Disorder
The Effect of N- Acetylcysteine on Inflammatory and Oxidative Stress Biomarkers
Background: . Bipolar disorders and tobacco use disorder are top of the causes of disability and mortality worldwide Objective: The aim of this study was to evaluate N-acetyl-cysteine (NAC) as an adjunctive treatment in patients…
- Trial name
- nac (NCT02420418)
- Testing
- N-acetyl-cysteine (NAC)
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS)
SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)
The goal of this observational study is to comprehensively profile six immune-mediated inflammatory diseases, including atopic dermatitis (AD), plaque psoriasis (PSO), hidradenitis suppurativa (HS), cutaneous T-cell lymphoma…
- Conditions
- Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO), Atopic Dermatitis (AD)
- Trial name
- SKINERGY (NCT07021495)
- Where
- 8 sites in Netherlands
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Acute Lung Injury
Biological Markers to Identify Early Sepsis and Acute Lung Injury
There are no clear markers to identify sepsis and acute lung injury at early stage in clinical settings which would result in improved survival of the patients. In collaboration with the research team led by Dr. Zhang at St.
- Trial name
- NCT00825357
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chimei Medical Center
Sepsis
HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis
Molecules indicating endothelial injury may serve as biomarkers for severe sepsis because of the critical role of endothelial injury in organ dysfunction during severe sepsis.
- Trial name
- NCT01847248
- Where
- China
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Migraine, Migraine Headache
The Impact of Acupuncture on Biomarkers of Brain Injury and Inflammatory Response in Migraine
Migraine is more than just a headache-it can involve changes in the brain and inflammation. Recent research suggests that acupuncture may help by calming pain signals and reducing inflammation in the body.
- Conditions
- Migraine, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- ACUPMIGRAINE (NCT07292506)
- Testing
- Standard acupuncture, Electroacupuncture, Laser Acupuncture
- Where
- Slovenia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Treatment-resistant Depression (TRD), Major Depression
Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression
Treatment-resistant depression (TRD) is a major clinical challenge affecting a substantial proportion of patients with major depressive disorder who do not adequately respond to conventional antidepressant treatments.
- Trial name
- TRD-BIOTMS (NCT07673913)
- Testing
- Intermittent Theta Burst Stimulation (iTBS)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
CIDP
Biomark Study: Predict Intravenous Immunoglobulin Responders in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
This study aims analyze the transcriptome to identify predictive biomarkers of IVIG in CIDP patients. 25 patients with a diagnosis of CIDP according to European criteria, naïve of treatment, will be included and followed for 1…
- Trial name
- BIOMARK (NCT02629796)
- Testing
- CIDP treated (IVIG)
- Where
- 18 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Healthy
Pomegranate Improve Biological Recovery Kinetics in Elite Weightlifter
From the recent scientific literature in the field of biological response to physical exercise, a significant increase in muscle damage, soreness and inflammation were registered immediately and even 48 after resistance exercise.
- Trial name
- NCT02697903
- Testing
- Natural Pomegranate Juice
- Where
- Tunisia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- The Higher Institute of Sport and Physical Education of Sfax
Sepsis, Early Diagnosis
The Biomarker Prediction Model of Septic Risk in Infected Patients
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Sepsis is associated with high mortality because of the complex mechanisms.
- Conditions
- Sepsis, Early Diagnosis, Biomarkers
- Trial name
- NCT05095324
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital