Clinical trials: Inflammatory Marker
Binge Eating, Obesity
The Effects of Repetitive Transcranial Magnetic Stimulation in Obese People With BED
The presence of binge eating (BE) is a core feature of bulimic syndromes. Binge eating disorder (BED) is a new category in DSM-5 highly associated with higher body mass index (BMI).
- Trial name
- NCT02180984
- Testing
- TMS
- Where
- Brazil
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Asthma, COPD
Asthma, Inflammation and G Protein-coupled Receptors (GPCR)
The G protein-coupled receptors (GPCRs) are a family of proteins expressed at the cell membrane. They are composed of 380 members involved in the important functions of the organism and are privileged therapeutic targets.Their…
- Trial name
- NCT00793676
- Testing
- spirometry, blood test
- Where
- 5 sites in France
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Vestibular Disorder, Headache
The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury
Test the hypothesis that a certain set of osteopathic manipulation procedures preformed on patients with mild to moderate traumatic brain injury will result in accelerated rates of recovery assessed using vestibular function…
- Conditions
- Vestibular Disorder, Headache, Traumatic Brain Injury
- Trial name
- NCT03163901
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Periapical Periodontitis
Effect of Corticosteroid Injection in Symptomatic Pulpitis Cases
This randomized clinical trial compared standard single-visit root canal treatment with adjunctive submucosal betamethasone and gentamicin in 100 patients with symptomatic irreversible pulpitis, assessing postoperative pain and…
- Trial name
- (SCIP) (NCT07704398)
- Testing
- Corticosteroid, Standard endodontic treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Reversible Pulpitis, Irreversible Pulpitis
Biomarkers for Differentiating Reversible and Irreversible Pulpitis
This observational study aims to evaluate the role of inflammatory, oxidative stress, neurogenic, and immunological biomarkers obtained from pulpal blood in the differential diagnosis of normal pulp, reversible pulpitis, and…
- Conditions
- Reversible Pulpitis, Irreversible Pulpitis, Healthy Pulp
- Trial name
- PULPBIOM (NCT07658742)
- Testing
- Pulpal Blood Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Safa
Periodontitis, Aggressive
The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis
The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis.
- Trial name
- NCT07526883
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Relapsing Multiple Sclerosis, Multiple Sclerosis
Sema 4A as a Marker for Inflammatory Disease in Multiple Sclerosis
Measure serum and cerebrospinal fluid Sema4A levels in female subjects with newly diagnosed and untreated relapsing multiple sclerosis, clinically stable relapsing multiple sclerosis receiving disease modifying therapy, relapsing…
- Trial name
- Sema4A MS (NCT05077956)
- Testing
- Cerebrospinal and Blood Serum Semaphorin 4A Levels
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Providence Health & Services
Telomere Length in Healthy Controls
Telomeres and T-cell Receptor Excision Circles (TRECs) From Peripheral Blood in Normal Subjects Over Time
The Investigators have established a cohort of patients with recent-onset inflammatory arthritis called Early Undifferentiated PolyArthritis (EUPA). This cohort was established to define novel biomarkers of poor outcomes.
- Trial name
- NCT01982890
- Testing
- Control
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cystic Fibrosis, Oxidative Stress
Flaxseed Modulates Inflammation and Oxidative Stress in CF
Flaxseed (FS) is a safe and well tolerated supplement with an ability to fight inflammation and oxidative stress - a byproduct of daily stress the human body faces everyday and especially with chronic diseases.
- Conditions
- Cystic Fibrosis, Oxidative Stress, Inflammation
- Trial name
- NCT02014181
- Testing
- finely ground flaxseed powder
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sepsis
Validation of Progranulin as a Biomarker for Sepsis
Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.
- Trial name
- PROGRANULIN (NCT03280576)
- Where
- 2 sites in Germany
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Asthma, Healthy
Inflammatory Markers in Exhaled Breath (Condensate) in Childhood Asthma
Background: Exhaled nitric oxide and inflammatory biomarkers in exhaled breath condensate may be useful to diagnose and monitor childhood asthma.
- Conditions
- Asthma, Healthy, Children
- Trial name
- NCT00404976
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Upper Respiratory Tract Infections
Probiotic Trial for URTI Prevention in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial in generally healthy adults aged 18-65 years will compare the incidence of upper respiratory tract infections (URTIs) over 16 weeks between probiotic supplement and…
- Trial name
- NCT07908797
- Testing
- Probiotic Formula
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Metabolic Syndrome
Resistance Training and Metabolic Syndrome
Metabolic syndrome (MetS) is a multicomponent disorder closely linked to low grade inflammation, and cardiovascular disease (CVD).
- Trial name
- NCT02918448
- Testing
- Training group
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Periodontal Disease, Pregnancy
Maternal Periodontal Inflammation and Pregnancy Outcomes: Salivary and Amniotic Biomarkers
Periodontal disease is a chronic inflammatory condition that affects the tissues supporting the teeth and may contribute to systemic inflammation and oxidative stress.
- Conditions
- Periodontal Disease, Pregnancy, Preterm Birth
- Trial name
- NCT07699978
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Somatoform Disorders, Fibromyalgia
Immune Patterns in Pain Patients DSM-IV
The purpose of this study is to define subgroups of patients with somatoform disorders due to DSM-IV by immunological, psychological and genetic characterization.
- Conditions
- Somatoform Disorders, Fibromyalgia, Myofascial Pain Syndrome, Diffuse, Depression
- Trial name
- IPPPDIV (NCT01106339)
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Multiple Sclerosis, Healthy Nutrition
Probiotic Chocolate Study in Multiple Sclerosis
The goal of this study is to assess the effects of probiotics on persons with multiple sclerosis (MS), persons at higher genetic risk for MS (first degree family members of persons with MS), and healthy controls.
- Trial name
- ProChocolate (NCT06475183)
- Testing
- Bouchard Belgian Dark Chocolate Probiotic Napolitains, containing bifidobacterium longum
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sepsis
Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock
The purpose of this research study is to determine if a chemical marker in the blood, hypoxia-inducible factor (HIF-1 alpha), can be used to predict subject's hospital outcomes when the subject is diagnosed with sepsis.
- Trial name
- NCT02163473
- Testing
- Septic patients, Healthy Control
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Florida
Graves' Orbitopathy, Thyroid Eye Disease, TED
Early Risk Stratification of Thyroid Eye Disease in Newly Diagnosed Graves' Disease
The aim of this observational study is to investigate why some people with newly diagnosed Graves' disease (GD) develop thyroid eye disease (TED), also known as Graves' orbitopathy, while others do not.
- Conditions
- Graves' Orbitopathy, Thyroid Eye Disease, TED, Graves' Disease
- Trial name
- SOGO (NCT07812194)
- Testing
- Study-related ophthalmological assessment and biospecimen collection, Blood biomarkers and standardized blood samples including thyroid function status
- Where
- Denmark
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Primary Biliary Cirrhosis
Identification of Inflammatory and Fibrotic Biomarkers in PBC and NAFLD Patients
Primary biliary cirrhosis (PBC) is a progressive autoimmune disease of biliary epithelial cells resulting in biliary cirrhosis. PBC is characterized by a 90% female predominance, high titers of serum anti-mitochondrial…
- Trial name
- NCT02477462
- Testing
- Clinic visit, Baseline visit
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
COVID-19-Associated Encephalitis, Multisystem Inflammatory Syndrome in Children
Investigation of Prognostic Biomarkers, Host Factors and Viral Factors for COVID-19 in Children
Background and objective From this April, there was a COVID-19 outbreak in Taiwan. The first fatal case of pediatric COVID-19 encephalitis was reported on April 19, 2022 and fatal fulminant cerebral edema in other 4 children with…
- Trial name
- NCT05576714
- Testing
- delineate its prognostic biomarker, host genetic factors, immunopathogenesis and viral pathogenesis
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital