Clinical trials: Inflammatory Mediators
Eosinophilic Esophagitis
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine…
- Trial name
- NCT03822325
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pain, Inflammation
Effects of Cryotherapy on Joint Function and Pressure Pain Threshold in Patients With Subacromial Impingement Syndrome.
Background: Subacromial impingement syndrome (SIS) is a chronic and disabling disease, characterized by compression and mechanical abrasion of the tendons of the rotator cuff muscles, subacromial bursa and tendon of the long head…
- Trial name
- NCT02351986
- Testing
- physical therapy, ice pack
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Type 2 Diabetes, Obesity
Resveratrol in Type2 Diabetes and Obesity
The main objective of this study is to investigate the effect of resveratrol (plant derived food supplement) on inflammatory mediators and insulin resistance at the cellular and molecular level in obese non diabetic and type 2…
- Conditions
- Type 2 Diabetes, Obesity, Insulin Resistance
- Trial name
- NCT01158417
- Testing
- Resveratrol 40 mg oral three times a day, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Knee Osteoarthritis
Osteoarthritis and Body Composition: Evaluation of Systematic Mediators
The purpose of this study is to examine the relationship between body composition and knee osteoarthritis, and effects of inflammatory, metabolic, and hormonal factors.
- Trial name
- NCT00771082
- Where
- United States
- Volunteers
- 1,033 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Sepsis, Surgery
Inflammatory Mediators of Acute Kidney Injury in Intensive Care
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality.
- Conditions
- Sepsis, Surgery, Acute Kidney Injury
- Trial name
- PronMed (NCT03720860)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Postoperative Dental Pain, Pulp Disease, Dental
Effect of Different Apical Actions on Local Inflammatory Mediators and Pain
The goal of this clinical trial is to determine patients' the inflammation and pain response to different apical actions used in rotary instrumentation during root canal shaping process.
- Conditions
- Postoperative Dental Pain, Pulp Disease, Dental, Pulpitis - Irreversible
- Trial name
- NCT06760312
- Testing
- Root canal shaping with Continuous Rotation, Root canal shaping with Apical Reverse, Root canal shaping is conducted with Apical slow-down kinematic.
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Postprandial Inflammation
Anti-inflammatory Effects of Fiber
The main objective of this research is to investigate the effect of addition of fiber on the high fat high carbohydrate (HFHC) meal induced inflammation and oxidative stress mechanisms at the molecular level in humans, in vivo.
- Trial name
- NCT02781350
- Testing
- HFHC meal, HFHC MEAL plus Fiber
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Ulcerative Colitis
Utility of Low Intensity Pulsed Ultrasound Stimulation (LIPUS) to Modulate the Release of Mediators Capable of Reflecting the Inflammatory State in the Affected Colonic Tract of Ulcerative Colitis Patients
The goal of this clinical trial is to learn whether Low Intensity Pulsed Ultrasound (LIPUS) is capable of promoting the release of extracellular vesicles from the gut into the bloodstream of Ulcerative Colitis (UC) patients…
- Trial name
- LIPUSinVIVO (NCT06569888)
- Testing
- LIPUS stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Asthma
Asthma/Steroid Withdrawal Study
The investigators propose to study the patterns of metabolite changes in subjects with asthma to determine if there is a predictable pattern prior to, and post, clinical exacerbation. Hypothesis: 1.
- Trial name
- NCT00395239
- Testing
- inhaled corticosteroid
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Metabolic Syndrome
Beneficial Effects of Exercise and Healthy Diets on Muscle and Adipose Tissue
Both dietary caloric restriction (CR) and physical exercise (PE) exert beneficial effects, which retard or prevent age-related diseases and prolong life span.
- Trial name
- NCT01793896
- Testing
- Control period, Diet Group, Exercise group
- Where
- Chile
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Chile
Molar-Incisor Hypomineralization (MIH)
Assessment of Peridontal Inflamatuar Markers in MIH
The goal of this observational study is to investigate periodontal inflammatory mediators in systemically healthy children aged 8-13 years with and without molar-incisor hypomineralization (MIH) who require initial periodontal…
- Trial name
- NCT07701642
- Testing
- Initial periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Marmara University
Blood Transfusion, Autologous
Effects of Blood Transfusion in Healthy Volunteers
The objective of this study is to assess effects of the storage of PRBC on endothelial function, inflammation and platelet activation in healthy volunteers
- Trial name
- NCT01226498
- Testing
- Red blood Cells auto-transfusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myopia, Astigmatism
Early Changes Among FLEx, LASIK and FS-LASIK
To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx), laser in situ keratomileusis (LASIK) and femtosecond laser-assisted laser in situ keratomileusis…
- Trial name
- NCT02551796
- Testing
- lenticule extraction, laser in situ keratomileusis, FS assisted laser in situ keratomileusis
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Hepatitis B, Chronic
Observe Change of Endotoxaemia and Related Mediators in Patients With Chronic Hepatitis B Virus (HBV) Infection
This study was designed for changes in endotoxaemia, endotoxin-binding factors, sICAM-1 (soluble intracellular adhesion molecule-1), and cytokines during progression of chronic HBV infection.
- Trial name
- OCEHBV (NCT01107483)
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Age-related Cataract
Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL
The purpose of the study it to compare the effects of Holy-Comod and Tears Naturale Forte on ocular surface and tear inflammatory mediators in patients after Phaco+IOL.
- Trial name
- NCT02817191
- Testing
- Hylo-Comod eye drop, Tears Naturale Forte eye drop
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Aging, Epigenetics
Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock
Topical Rapamycin ointment will be applied to participant forearms to test whether epigenetic changes in the skin are elicited.
- Conditions
- Aging, Epigenetics, Inflammatory Mediators
- Trial name
- Topical-RAPA (NCT04608448)
- Testing
- Rapamycin Topical Ointment
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Inflammatory Response, Root Canal Infection
Releasing of Inflammatory Mediators During Retreatment of Root Canals
Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper…
- Trial name
- NCT05039502
- Testing
- Protaper Universal Retreatment, Reciproc, XP-Endo finisher R
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Glaucoma, Corneal Transplantation
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation.
- Conditions
- Glaucoma, Corneal Transplantation, Inflammation
- Trial name
- AH-Tears (NCT04339907)
- Testing
- Sampling of tears, Sampling of aqueous humor
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hypertriglyceridemia With the Metabolic Syndrome
Effects of Micronized Fenofibrate on Fasting and Postprandial Lipoproteins, Inflammatory Mediators and Thrombosis
This is a randomized placebo controlled clinical trial designed to investigate the effects of micronized fenofibrate on fasting and postprandial lipoproteins, oxidized fatty acids and lipoproteins, inflammatory mediators and…
- Trial name
- NCT00422396
- Testing
- Fenofibrate (drug)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Posterior Blepharoconjunctivitis
A Four Week, Open-Label Study of Azithromycin Ophthalmic Solution, 1% (P08641)
One objective of this study is to determine the levels of markers of inflammation on the eyelid margin of subjects with blepharoconjunctivitis and compare them with those of healthy volunteers.
- Trial name
- NCT01220258
- Testing
- Azithromycin ophthalmic solution, 1%
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC