Clinical trials: Inhalation
Paradoxical Fall in Maximum Expiratory Flows
Search of a Paradoxical Fall in Maximum Expiratory Flow After Bronchodilation in Healthy Subjects
There exists a physiological limitation of the expiratory flows because of the physical properties of the bronchial tree (flexible bronchial walls in a complex architecture subjected to variations of pressure and volume).
- Trial name
- VACUVOL (NCT03062904)
- Testing
- Inhaled Bronchodilators +/- Inhaled Methacholine
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
AZD5423 Multiple Ascending Dose Study
The aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD5423 following multiple ascending dose administrations in healthy male and female subjects
- Trial name
- NCT01037504
- Testing
- AZD5423
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Insomnia, Hypersomnia
Sleep Disorders and Their Cardiovascular Correlates in Atahualpa.
Little is known on the prevalence of sleep disorders and their role in the increased prevalence of cardiovascular diseases in the developing world.
- Conditions
- Insomnia, Hypersomnia, Sleep-disordered Breathing, Stroke
- Trial name
- NCT01877616
- Testing
- diagnostic test
- Where
- Ecuador
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Hospital Clínica Kennedy
Healthy Volunteers
A Study to Assess the Relative Bioavailability After a Single Inhalation Administration of Treprostinil Palmitil Inhalation Powder (TPIP) Formulation 2 (F2) to TPIP Formulation 3 (F3) in Healthy Participants
The primary objective of this study is to determine the relative bioavailability of treprostinil (TRE) between the TPIP F2 and TPIP F3 at 3 capsule strengths, dose A, dose B, and dose C, in healthy participants following a single…
- Trial name
- NCT07102316
- Testing
- TPIP F2, TPIP F3
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Insmed Incorporated
Stress, Stress, Psychological
The Effect of SKY Breath Meditation on Health and Well-being
The goal of this pilot SKY (Sudarshan Kriya Yoga) Breath Meditation study is to establish feasibility and acceptability of the intervention; and investigate preliminary effectiveness of the intervention at the DNA methylation…
- Conditions
- Stress, Stress, Psychological, Stress, Physiological, Anxiety
- Trial name
- NCT05523414
- Testing
- SKY
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
To Assess Safety, Tolerability and Pharmacokinetics of BI 443651 in Healthy Male Volunteers
To investigate safety, tolerability and pharmacokinetics, following single doses of BI 443651
- Trial name
- NCT02706925
- Testing
- BI 443651
- Where
- Germany
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Pharmacokinetics and Safety Study of ME1100 in Healthy Volunteers
This is a single-center, randomized, double-blind, placebo-controlled, sequential group study. The primary objective of this study is to assess the tolerability and safety of single doses of ME1100 inhalation solution (orally…
- Trial name
- NCT01907776
- Testing
- ME1100 inhalation solution
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Meiji Seika Pharma Co., Ltd.
Fluid Responsiveness, Hemodynamics
Hemodynamic Evaluation and Fluid Response Observation Through Respiratory Maneuvers
This study evaluates whether respiratory maneuvers can induce measurable hemodynamic changes and whether these changes may be used to assess fluid responsiveness in healthy volunteers.
- Trial name
- HERO (NCT07840040)
- Testing
- Respiratory Maneuvers and Fluid Responsiveness Assessment Protocol
- Where
- Czechia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital Pilsen
Sleep Disordered Breathing, Sleep Apnea, Central
Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders
Comparing two BiPAP autoSV devices in participants with complex sleep apnea and determining if the new device will treat those participants no worse than when compared to its predecessor device.
- Trial name
- NCT01626989
- Testing
- BiPAP auto Advanced, BiPAP auto SV4
- Where
- 3 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Philips Respironics
Diaphragm; Relaxation
The Influence of the Diaphragm Muscle and Pain Perception on Lower Limb Neuromuscular Control in Sports Practice.
Core stability is maintained mainly by muscle function of abdominal and lumbar region, including the diaphragm muscle. It is known that exists a connection between trunk's muscle activity and the movement of lower limb and lower…
- Trial name
- NCT05982210
- Testing
- Breathing Exercises and Manual Therapy of the Muscle Diaphragm and Ribs Protocol
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Health
Bioequivalence Study Between UI009 and UIC202005 in Healthy Subjects
A Randomized, Open-label, Single-dosing, 2x2 Crossover Study to Evaluate Bioequivalence After Dry-powder Inhalation of UIC202005 or UI009 in Healty Volunteers
- Trial name
- NCT07110740
- Testing
- UI009, UIC202005
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Hypertension, Prehypertension
Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
The purpose of this study is to assess the efficacy of inspiratory muscle strength training for lowering blood pressure and improving physiological function (vascular, motor, and cognitive) in middle-aged and older adults with…
- Conditions
- Hypertension, Prehypertension, Aging
- Trial name
- NCT03266510
- Testing
- Inspiratory muscle strength training
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Douglas Seals
Covid19
Safety of Ascending Doses of Niclosamide (UNI911 INHALATION) in Healthy Volunteers
This is a Phase 1 Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess the Safety of Ascending Doses of UNI911 INHALATION in Healthy Volunteers in Preparation for Evaluation in Adults with COVID-19
- Trial name
- NCT04576312
- Testing
- UNI911 inhalation 1% and intranasal spray 1%
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- UNION therapeutics
Sleep Quality
Sleep Quality and the Menstrual Cycle
This study aims to examine how ovarian hormone fluctuations across the menstrual cycle affect sleep patterns. Using objective sleep tracking, hormone phase assessment, and validated questionnaires, it will assess changes in sleep…
- Trial name
- NCT06906133
- Testing
- Urinary-hCG
- Where
- 2 sites in Iceland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Akureyri
Smoking
Airway and Pulmonary Vascular Endothelial Function in Healthy Smokers: Effect of Inhaled Glucocorticosteroid Treatment
The purposes of the present proposal are to 1) compare inhaled albuterol-induced changes in airway blood flow (Qaw), and in CO and Ppas in healthy current smokers and lifetime non-smokers as an index of endothelial function in…
- Trial name
- smoker3 (NCT02141633)
- Testing
- echocardiogram plus albuterol, airway blood flow plus albuterol, Fluticasone propionate
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Miami
Ventricular Septal Defect
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.
The overall objective for this study is to test whether β2-agonists will affect the cardiopulmonary capacity of VSD-operated patients compared with un-operated VSD-patients and healthy age- and gender-matched controls.
- Trial name
- NCT02914652
- Testing
- Salbutamol
- Where
- Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Asthma
Study to Look at and Compare How Inhaled and Intravenous Fluticasone Furoate and GW642444 Are Processed by the Body in Healthy Subjects
This study is being done to look at the absolute bioavailability of fluticasone furoate and GW642444 inhalation powder when administered in healthy subjects.
- Trial name
- NCT01299558
- Testing
- fluticasone furoate//GW642444, fluticasone furoate, GW642444
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Asthma
Lung Deposition of Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide Administered Via pMDI in Healthy, Asthmatic and COPD Patients
The purpose of this study is to investigate the lung deposition and distribution pattern of Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium Bromide using a Gamma-scintigraphic technique after inhalation of a single…
- Trial name
- NCT02975843
- Testing
- Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Colonic Disease
Effect of Lavender Oil Inhalation in Colonoscopy Patients
Aim: In this study, it was aimed to determine the effect of lavender oil inhalation on the anxiety and comfort levels of patients who will undergo colonoscopy.
- Trial name
- NCT05540418
- Testing
- lavender oil inhalation
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Diabetes Mellitus, Type 2, Anesthesia
Investigation of the Evolution of Gastric Emptying by Gastric Ultra Sonography in Patients Treated With GLP-1 Receptor Agonists on a 7 Days Pausing Period.
Glucagon-like-peptide-1 is a hormone released by the gut enteroendocrine cells. Its secretion occurs after each meal to enable production of insulin and inhibits the production of glucagon to lower after meal glycemia.
- Conditions
- Diabetes Mellitus, Type 2, Anesthesia, Pulmonary Aspiration of Gastric Contents
- Trial name
- NCT06388213
- Testing
- Gastric Ultrasonography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
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