Clinical trials: Inhalation
COPD
Phase 1/Phase 2a Study of AERO-007 Inhalation Solution, a Nebulized LABA/LAMA Combination for Maintenance Treatment of COPD
This is a phase 1/phase 2a, single dose, crossover study conducted in two parts. Part 1: Phase 1, open-label, 4-period crossover study in 8 healthy subjects to determine the optimal dose of AERO-001 and AERO-002, the active…
- Trial name
- NCT06841640
- Testing
- AERO-001, AERO-002, AERO-007
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AeroRx Therapeutics Inc.
Healthy Volunteers
ADASUVE 2-dose Thorough QT/QTc Study
Assess the potential effects on the QT interval of 2 consecutive doses of ADASUVE administered 2 hours apart, in relation to placebo and an active control in healthy volunteers.
- Trial name
- NCT01854710
- Testing
- ADASUVE 10 mg 2 doses 2 hours apart, Oral moxifloxacin 400 mg
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Hypertension, Pulmonary
A Proof of Concept Study of Electrical Discharge Produced Nitric Oxide for Inhalation
Study Design: This is a two-part physiological for a device feasibility. Both studies are proof of concept descriptive pilot studies.
- Trial name
- NCT02305550
- Testing
- electrical pulsed plasma discharge synthesis of nitric oxide
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Postmenopausal Symptoms, Aging
Inspiratory Muscle Training in Postmenopausal Women
This study is being conducted by the Department of Kinesiology within the School of Public Health at Indiana University Bloomington.
- Conditions
- Postmenopausal Symptoms, Aging, Obesity
- Trial name
- MRS (NCT06459674)
- Testing
- PrO2 Fit (IMT Trainer)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cystic Fibrosis (CF)
Safety, Tolerability and Pharmacokinetics Study of AIR DNAse Administered by Inhalation to Healthy Adult Volunteers
This study will be performed to assess the safety, tolerability and PK of escalating inhaled AIR-DNase doses administered as a single dose followed by multiple doses for 5 consecutive days in healthy subjects.
- Trial name
- NCT02605590
- Testing
- AIR DNase
- Where
- Israel
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Protalix
Asthma
Comparison of Salmeterol and Fluticasone Propionate Absorption From Salmeterol/Fluticasone Easyhaler and Seretide Diskus
The purpose of this study is to compare the test product Salmeterol/fluticasone Easyhaler with the reference product Seretide Diskus in terms of drug absorbed in the bloodstream.
- Trial name
- NCT01766843
- Testing
- Seretide Diskus and charcoal, Seretide Diskus, SF Easyhaler and charcoal
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Forward Head Posture
Comparison Between Dynamic Neuromuscular Stabilization Breathing and Manual Therapy on Forward Head Posture in University Students
Forward Head Posture (FHP) is a common postural dysfunction characterized by the anterior displacement of the head relative to the shoulders, leading to cervical spine misalignment, increased muscle strain, and neck pain.
- Trial name
- NCT07721389
- Testing
- Dynamic neuromuscular stabilisation breathing, Myofascial Release, Convetional Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istinye University
Fear Anxiety
Inhalation Treatment Distraction in Children
The aim of the project is to examine the effects of two different distraction methods used in preschool children receiving inhalation therapy on fear and anxiety levels.
- Trial name
- NCT06874491
- Testing
- Moving and 3D Book, Hand Puppet
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Asthma
Comparison of Absorption of Budesonide and Formoterol From Budesonide/Formoterol Easyhaler and Symbicort Turbuhaler
The purpose of this study is to compare the test product Budesonide/formoterol Easyhaler with the marketed product Symbicort Turbuhaler in terms of the drug absorbed into the bloodstream.
- Trial name
- NCT01593826
- Testing
- Charcoal and Budesonide/formoterol Easyhaler 320/9 microg, Charcoal and Symbicort Turbuhaler, Budesonide/formoterol Easyhaler 320/9 microg
- Where
- Finland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Weight Loss, Metabolism
Effects of Novel Breathing Behavior Modification Yoga Positioning Integrated Program on Weight Loss
This study is to evaluate the physical and cognitive effects of a 15 min per day novel breathing and mindfulness moving-meditation program on metabolism, cognition, and emotion health.
- Trial name
- Breathing (NCT05488574)
- Testing
- Deep breathing with Yoga positioning
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Touro University Nevada
Chronic Obstructive Pulmonary Disease
Effects Of of Pursed Lip Breathing and Coordinated Breathing in Adult Patients With COPD
COPD is the chronic lung condition characterized by the damage and enlargement of the air sacs in the lungs, leading to breathing difficulties. A blockage may develop, which traps air inside your lungs.
- Trial name
- NCT06459843
- Testing
- pursed lip breathing techniques, coordinated breathing technique
- Where
- Pakistan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Hypertension, FXTAS
Diaphragmatic Breathing and Heart Rate Variability Training for Improving Hypertension in Fragile X Associated Tremor/Ataxia
To study whether heart rate variability training and respiratory coherence can improve hypertension in individuals with FXTAS. All patients will receive HRV biofeedback training for 20 sessions.
- Trial name
- NCT03816540
- Testing
- HRV and respiratory coherence biofeedback
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Chronic Obstructive Pulmonary Disease
Exhaled Breathing Condensate (EBC) Features and Lung Function Decline in Chinese Adults
Chronic obstructive lung disease (COPD) is a worldwide leading and still increasing cause of chronic morbidity and mortality. The important issue of COPD is its delayed diagnosis.
- Trial name
- NCT02037828
- Where
- China
- Volunteers
- 2,440 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Fetal Testing, Transplacental Transfer of Acetaminophen
Acetaminophen Transfer Across the Placenta and the Assessment of Fetal Well-being
This study has two aims: 1. to evaluate placental transfer of acetaminophen from mother to baby transplacentally given from 30 minutes to 24 hours prior to cesarean delivery (34 patients) 2.
- Trial name
- NCT01211912
- Testing
- Arm 1 (20 patients), Arm 2 (34 patients)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pharmacokinetics
A Study To Estimate The Time Course Of PF-00241939 Concentration In The Blood After Dosing With Oral Inhalation From Dry Powder Inhalers
The purpose of this study is to investigate the time course of PF-00241939 concentrations in the blood following dosing by oral inhalation using dry powder inhalers.
- Trial name
- NCT01181700
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- Singapore
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Participants
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled AZD4604 in Healthy Japanese and Chinese Participants.
The purpose of this study is to investigate the safety, tolerability, and pharmacokinetics (PK) of AZD4604 when administered as single or multiple inhaled doses to healthy Japanese and Chinese participants.
- Trial name
- NCT06519968
- Testing
- AZD4604
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
10-13 Age, Inspiratory Muscle Training
Effects of Inspiratory Muscle Training Combined With Circadian Rhythm-based Running Programs in Children Male Football Players
In this study, a parallel two-group pre-test-post-test randomized controlled trial was conducted according to CONSORT guidelines.
- Conditions
- 10-13 Age, Inspiratory Muscle Training, Running, Circadian Rhythm
- Trial name
- Circadian IMT (NCT07170891)
- Testing
- Morning Running and IMT, Inspiratory muscle training and evening running, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Healthy Adult Male
Wearable Resistance Vest for Strengthening Respiratory Muscles
Respiratory muscle weakness significantly limits functional capacity in various populations, yet conventional respiratory muscle training (RMT) often requires coached, mouthpiece-based maneuvers that may be limited by technique…
- Trial name
- WEARVEST (NCT07698873)
- Testing
- Wearable Resistance Vest
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Hypoxia, Hypercapnia
The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing
The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.
- Conditions
- Hypoxia, Hypercapnia, Cardiac Output, High
- Trial name
- HYPERCO (NCT05441007)
- Testing
- Hypoxic, Hypercapnic, Hypoxic and Hypercapnic
- Where
- Czechia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
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