Clinical trials: Inhalation
Healthy Volunteers, Safety
Safety of Ascending Single and Multiple Doses of Nebulised SoftOx Inhalation Solution in Healthy Subjects
Background: This first-in-human study will investigate the safety and tolerability of single and multiple doses of nebulised SoftOx Inhalation Solution (SIS) delivered via a jet nebuliser to healthy subjects.
- Trial name
- NCT05188638
- Testing
- SoftOx Inhaled Solution (SIS)
- Where
- Denmark
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- SoftOx Solutions AS
Coronary Artery Disease
The Predictive Value of the Heart Rate Response to Breathing Maneuvers for Inducible Myocardial Perfusion Deficits
Breathing maneuvers, i.e. hyperventilation followed by breath-holding, have been shown to change coronary dynamics; hyperventilating narrows the coronary arteries, puts "stress" on the heart, and increases the heart rate, whereas…
- Trial name
- SCREEN-MORE (NCT05516615)
- Testing
- 4 minute breathing maneuver
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ophthalmic, Surgery
Comparison of Desflurane Anesthesia Versus TIVA-TCI in Patients Undergoing Ophthalmic Ambulatory Surgery
This is a single-center, randomized, prospective research which aims to investigate the advantages and disadvantages between desflurane balanced anesthesia and TIVA-TCI with propofol in ophthalmic ambulatory surgery, so that to…
- Conditions
- Ophthalmic, Surgery, Anesthesia
- Trial name
- NCT02922660
- Testing
- desflurane, total intravenous anesthesia, inhalation anesthesia
- Where
- China
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Xiaoliang Gan
Pulmonary Disease, Chronic Obstructive
A Study to Assess the Safety and Pharmacokinetics of Inhaled Doses of GSK233705 and GW642444 in Healthy Subjects.
GW642444 and GSK233705 are in development for treatment of Chronic Obstructive Pulmonary Disease. Development of these two inhaled drugs as a combination therapy would have potential for improved patient benefit as they both work…
- Trial name
- NCT00671216
- Testing
- GSK233705, GW642444, GSK233705 and GW642444
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Nursing Students
The Effect of Music Therapy and the 4-7-8 Breathing Exercise
Objective: This study was conducted to evaluate the effectiveness of music therapy and 4-7-8 breathing exercises in managing anxiety among nursing students during IV drug administration education.
- Trial name
- NCT07425847
- Testing
- Music therapy, breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Inonu University
Sleep Disordered Breathing, Hypoxia
AT1R Blockade and Periodic Breathing During Sleep in Hypoxia
Sleep disordered breathing (SDB) is characterized by regular periods of no breathing (apnea) or low levels of breathing (hypopnea) and leads to repeated periods of low oxygenation, termed intermittent hypoxia that causes…
- Conditions
- Sleep Disordered Breathing, Hypoxia, Respiration; Sleep Disorder, Chemoreceptor Apnea
- Trial name
- NCT03335904
- Testing
- Hyperoxic Hypercapnic Ventilatory Response Test, Hypoxic Hypercapnic Ventilatory Response Test, Repeated Hypoxic Apneas
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Volunteers
An Exploratory PET-study of Deposition, Disposition and Brain Uptake of [11C]Nicotine After Inhalation of 2 Nicotine Formulations Via the myBluTM E-cigarette in Smokers
This is a single-center, exploratory positron emission tomography (PET) study of deposition, disposition and brain uptake [11C]nicotine when given to smokers as two different formulations via mybluTM e-cigarette system.
- Trial name
- NCT04780815
- Testing
- myBluTM Formulation 1, myBluTM Formulation 2
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Imperial Brands PLC
Pulmonary Disease, Chronic Obstructive
GSK573719 IV Enabling Study
A single-centre, open-label, sequential, cross-over study to examine the safety, tolerability and pharmacokinetics of 3 ascending single intravenous doses, a single 1000μg oral dose and a single 1000μg inhaled dose of GSK573719…
- Trial name
- NCT01110018
- Testing
- GSK573719 (SOLUTION), GSK573719 (INHALATION POWDER)
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Respiratory Muscle Function and Football Performance
Acute Effects of Breathing Resistance During Exercise in Football Players
This randomized crossover study will examine the immediate effects of breathing resistance during exercise in 35 active football players aged 18-30 years.
- Trial name
- NCT07907510
- Testing
- Breathing-Resistance Exercise Mask, No-Mask Exercise
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Copd, Ventilation
Assessment of Neural Inspiratory Time Through sEMG and EMGdi
The onset and offset of the neural inspiratory time are fundamentally important measurements in studies of patientventilator interaction, where the level of assistance delivered by the ventilator is controlled by the patient's…
- Conditions
- Copd, Ventilation, Rehabilitation
- Trial name
- NCT04211038
- Testing
- inspiratory threshold load device
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhenfeng He
Lung Cancer, Oral Cancer
Exploratory Study of Inhaled Afatinib Dimaleate PK Profile
This is a pilot Phase I open-label randomized single-dose two-period crossover study (in the EDDIS project) evaluating the bioequivalence, pharmacokinetics (PK), safety, and tolerability of inhaled afatinib dimaleate compared…
- Conditions
- Lung Cancer, Oral Cancer, Melanoma
- Trial name
- EDDIS-a1 (NCT06897735)
- Testing
- Afatinib Dimaleat, inhalation of afatinib dimaleate
- Where
- New Zealand
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Petrov, Andrey
State Key Laboratory of Respiratory Disease
Study of Neural Inspiratory Time and Expiratory Delay in Patient and Health During Spontaneous Breathing and Ventilation
To make these definitions of neural inspiratory time (Ti) and expiratory delay clearly.The present study was undertaken to examined the physiological signals of patients and healthy subjects during spontaneous breathing and…
- Trial name
- NCT02817035
- Testing
- noninvasive mechanical ventilation
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Vital Signs
A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application
This study validates Lifelight® First, a software application, in a laboratory setting. Participants will undergo testing to obtain measurements from one or more of the four vital signs.
- Trial name
- NCT03998098
- Testing
- Oxygen Saturation (Oximetry), Heart Rate (Pulse), Respiratory Rate
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Xim Limited
Diaphragm Pacing
Effects of Combined Thoracic and Diaphragmatic Breathing on Cognitive and Psycho-Physiological Functions
This study aims to investigate the effects of a combined thoracic expansion exercise (TEE) and slow diaphragmatic breathing (SDB) program on cognitive function, brain activation, psychological status, and head-shoulder posture in…
- Trial name
- NCT07620249
- Testing
- thoracic expansion exercises and slow diaphragmatic breathing
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Clinical Trial Center
Desflurane, Anesthesia, General
The Effect of Anthropometrics on Desflurane Rise Time
Desflurane is increasingly used in general anesthesia. Its pharmacokinetic properties are known and its distribution is easily modeled. Yet these models fail in practice.
- Trial name
- NCT06026033
- Testing
- Desflurane induction
- Where
- Turkey (Türkiye)
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Hyperoxemia, Oxygen Reserve Index
Oxygen Reserve Index and Prevention of Hyperoxemia
In patients under general anesthesia, the oxygen level (FiO2) used in inspiration is usually adjusted by monitoring the peripheral oxygen saturation level (SpO2).
- Conditions
- Hyperoxemia, Oxygen Reserve Index, Hyperoxia, Fraction of Inspired Oxygen
- Trial name
- NCT05505032
- Testing
- Oxygen, Masimo Root Radical 7
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
High Blood Pressure
Breathe: Slow Paced Breathing to Lower Blood Pressure
The purpose of this study is to investigate the nature of the physiological reasons for the decreases in resting blood pressure that can result from systematic practice of computer-guided breathing exercises or meditative…
- Trial name
- NCT00328016
- Testing
- Guided Breathing, RESPeRATE
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Respiration Disorders
Normal Variability of Tidal Breathing Flow-volume Curves During Sleep in Healthy Children
The study includes a comprehensive health examination with focus on respiratory health and the TBFV recordings using impedance pneumography (Ventica®) during sleep at night in healthy children.
- Trial name
- NCT03785847
- Testing
- Ventica
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Chronic Obstructive Pulmonary Disease
Pennsylvania Study Of Chronic Obstructive Pulmonary Exacerbations
The overall purpose of PA-SCOPE is to determine why black and rural residents of Pennsylvania might be at higher risk for deadly, debilitating, and costly hospitalizations for chronic obstructive pulmonary disease (COPD)- and…
- Trial name
- PA-SCOPE (NCT00774176)
- Where
- 3 sites in United States
- Volunteers
- 1,066 people, healthy volunteers welcome
- Sponsor
- Temple University
Breathing Rate
Coherence Breathing Before Cardiopulmonary Exercise Testing
This randomized crossover trial will examine the acute effects of pre-exercise coherence breathing on cardiopulmonary exercise responses in recreationally active adults.
- Trial name
- NCT07650279
- Testing
- Coherence Breathing, Spontaneous Breathing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Human Performance Lab of Monmouth University
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