Clinical trials: Inhalation Pneumonia
Covid19
Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Inhaled APN01 Developed as Treatment for COVID-19
APN01 is a soluble recombinant form of the human angiotensin-converting enzyme 2 (rhACE2) that is currently under development as a therapy for corona-virus-disease 2019 (COVID-19).
- Trial name
- NCT05065645
- Testing
- Angiotensin Converting Enzyme 2, Sodium chloride
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Apeiron Biologics
Aspiration Pneumonia
Gastric POCUS for Airway Management in Patients Using Glucagon-like Peptide-1 Receptor Agonist (Multicentric)
1. Introduction Scheduled surgery requires patients to undergo a preoperative fasting period of at least 6 hours to reduce the risk of perioperative pulmonary aspiration.
- Trial name
- POCUS (NCT06666049)
- Testing
- Gastric Ultrasound
- Where
- 2 sites in Spain
- Volunteers
- 39 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Covid19
EVALUATING THE EFFICIENCY OF BREATHING EXERCISES PERFORMED BY POST-COVID TELEMEDICINE: Randomized Controlled Study
As an important non-drug intervention in the treatment of respiratory tract diseases, respiratory rehabilitation training is increasingly accepted in clinical practice.
- Trial name
- NCT04771598
- Testing
- Breathing exercise with the phone application, Breathing exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Tokat Gaziosmanpasa University
Covid19
Analysis of Breathing Pattern Post COVID-19
The COVID-19 pandemic, a disease caused by the SARS-CoV-2 virus, has generated an inexplicable scenario for global health, causing different complications and degrees of functional impairment in millions of people who manage to…
- Trial name
- NCT05659615
- Testing
- Study will not have intervention
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Shirley Lima Campos
COVID-19 Pneumonia
Effects of IMT on Functional Capacity in Patients With Chronic COVID After Hospital Discharge
Exercise intolerance and fatigue are the most common symptoms in patients with chronic COVID after hospital discharge. Muscle deconditioning, dysautonomia, and exercise hyperventilation have been proposed as potential mechanisms…
- Trial name
- InsCOVID (NCT05279430)
- Testing
- Inspiratory muscle training
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Dysphagia, Aspiration Pneumonia
FEES to Determine Neurological Intensive Care Patients' Oral Diet
Dysphagia is associated with high rates of mortality and morbidity. Adjusting the oral diet of ICU-patients based on flexible endoscopic evaluation of swallowing (FEES) findings might reduce pneumonia rate, mortality and need for…
- Conditions
- Dysphagia, Aspiration Pneumonia, Deglutition Disorders, Intensive Care Neurological Disorder
- Trial name
- NCT03753841
- Testing
- Adjustment of oral diet
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- University of Giessen
Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
Study to Assess Efficacy and Safety of Inhaled Interferon-β Therapy for COVID-19
The purpose of this Phase III study is to confirm that SNG001 can accelerate the recovery of hospitalised patients receiving oxygen with confirmed Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- SPRINTER (NCT04732949)
- Testing
- SNG001
- Where
- 112 sites in United States, Argentina and 15 more
- Volunteers
- 623 people
- Sponsor
- Synairgen Research Ltd.
Respiratory Disease
Analysis of Vital Signs in Patients With COVID-19
This project will use data obtained from a proprietary vision-based patient monitoring and management system (OxeVision) for measuring heart rate and respiratory rate which is in clinical use at the Coventry and Warwickshire…
- Trial name
- NCT04927078
- Testing
- Observation of breathing pattern
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Oxehealth Limited
Lung Transplant; Complications, Ventilator-Induced Lung Injury
Inspiratory Work of Breathing Before and After Extubation
Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator).
- Conditions
- Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
- Trial name
- INTEGRATION (NCT07017608)
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- University Health Network, Toronto
COVID-19 Severe Respiratory Failure
Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19
In patients with COVID-19, severe hypoxemic respiratory failure (SRF) leading to invasive mechanical ventilation (IMV), raises the mortality rate substantially.
- Trial name
- NCT05279391
- Testing
- Dexamethasone, Low molecular weight heparin, Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Democritus University of Thrace
Covid19
Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes
Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index…
- Trial name
- NCT05777720
- Testing
- Filtration Fan, Safe-home pamphlet, Mid-week phone call
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Stanford University
ARDS Associated With COVID-19
Flow Controlled Ventilation in ARDS Associated With COVID-19
The pandemic of a newly upcoming viral disease which is associated with COVID-19 puts the whole world's health system under pressure.
- Trial name
- NCT04399317
- Testing
- Flow controlled ventilation (Evone-ventilator)
- Where
- Qatar
- Volunteers
- 20 people
- Sponsor
- Hamad Medical Corporation
Covid19
Effect of Prone Position onV/Q Matching in Non-intubated Patients With COVID-19
A prospective physiologic study, in participants with COVID-19-related pneumonia requiring supplemental oxygen (standard oxygen therapy or high-flow nasal cannula (HFNC)) less than 24 hours.
- Trial name
- NCT04754113
- Testing
- prone position
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Southeast University, China
COVID-19
Effectiveness of Exercise and Physical Activity in Individuals.
The effects of breathing exercises and physical activity counseling applied for 4 weeks on the number of daily steps, dyspnea, pain, fatigue, mood and quality of life in individuals who have just had COVID-19 are not yet known.
- Trial name
- NCT07000331
- Testing
- Thoracic expansion exercises, Physical activity counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Gulsah Bargi
Coronavirus
A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia
In December 2019, a novel coronavirus infectious disease characterized by acute respiratory impairment due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan city of Hubei province in China.
- Trial name
- NCT04276987
- Testing
- MSCs-derived exosomes
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
Coronavirus Infection, Cytokine Storm
Yoga Pranayama Adjuvant to Treat Burden COVID-19
COronaVIrus Disease or Severe Acute Respiratory Syndrome -CoV-2 or COVID-19, mortality occurs mainly from immunological behavior or by suicide after healing .
- Conditions
- Coronavirus Infection, Cytokine Storm, Mental Disorder
- Trial name
- YOCO (NCT04413747)
- Testing
- morning Yoga-based breathing support, pre_lunch Yoga-based breathing support, pre_dinner Yoga-based breathing support
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Health Ricerca e Sviluppo S.R.L.
COVID-19
Inspiratory Muscle Training in Post COVID-19 Infection Subjects
Long-term COVID has been considered a clinical condition in which the patient, after the critical period of the disease, still has systemic symptoms such as muscle weakness, inability to exercise, sleep disorders and it is still…
- Trial name
- NCT05282199
- Testing
- INSPIRATORY MUSCLE TRAINING
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Universidade Federal de Pernambuco
Pneumonia, Bacterial
Inhaled Amikacin Solution BAY41-6551 as Adjunctive Therapy in the Treatment of Gram-Negative Pneumonia
To demonstrate that as adjunctive therapy to intravenous (IV) antibiotics, BAY 41-6551 400 mg (amikacin as free base) administered as an aerosol by the Pulmonary Drug Delivery System (PDDS) Clinical every 12 hours is safe and…
- Trial name
- INHALE 1 (NCT01799993)
- Testing
- Amikacin Inhalation Solution (BAY41-6551)
- Where
- 65 sites in United States, Australia and 10 more
- Volunteers
- 725 people
- Sponsor
- Bayer
Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2 (Disorder)
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled MBS-COV (SNS812) in Healthy Participants
A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled MBS-COV in Healthy Participants
- Trial name
- NCT05677893
- Testing
- MBS-COV
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Oneness Biotech Co., Ltd.
Post Operative Complications, Pneumonia
Inpatient ICOUGH RECOVERY App Version 2.0
This pilot study will evaluate how well version 2 of the ICOUGH app, a bed-side mobile app increases patients' adherence to a postoperative protocol called ICOUGH.
- Trial name
- ICOUGH (NCT03599037)
- Testing
- ICOUGH Recovery App v2.0
- Where
- United States
- Sponsor
- Boston Medical Center