Clinical trials: Inhalation Pneumonia
Dysphagia, Oropharyngeal, Dysphagia
Slow-Stream Expiratory Muscle Strength Training for Veterans With Dysphagia Living in Long-term Care
Sunnybrook Veterans Centre (VC) is a long-term care (LTC) facility with many elderly residents living with swallowing disorders who are at high risk of developing pneumonia from aspirating food/liquid into their lungs.
- Conditions
- Dysphagia, Oropharyngeal, Dysphagia, Dysphagia, Progressive, Aging
- Trial name
- NCT04064333
- Testing
- Slow-Stream Expiratory Muscle Strength Training
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
ARDS
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60…
- Trial name
- CAVIARDS (NCT03963622)
- Testing
- Respiratory Mechanics, Standard Ventilation Strategy
- Where
- 33 sites in United States, Argentina and 6 more
- Volunteers
- 740 people
- Sponsor
- Unity Health Toronto
Covid19, Hypertension
Inspiratory Muscle Trainer and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Persistent Symptoms
Inspiratory muscle training considered as safe and valid method to improve respiratory muscle strength and functional capacity among uncountable conditions which could improve post COVID-19 persistent symptoms including but not…
- Conditions
- Covid19, Hypertension, Corona Persistent Symptoms
- Trial name
- NCT04919031
- Testing
- Inspiratory muscle trainer, diaphragmatic release
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Ventilator Associated Pneumonia ( VAP)
Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia
Article: Clinical Outcomes of Inhaled Amikacin in Ventilator-Associated Pneumonia: A group randomized controlled,add-on trial English:Patients in intensive care units often need ventilators to breathe.
- Trial name
- RCT (NCT07369336)
- Testing
- Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Postgraduate Medical Institute, Lahore
COVID19
Nitric Oxide Inhalation Therapy for COVID-19 Infections in the ED
The spread of novel Coronavirus (2019-nCoV) related infection (COVID-19) has led to many patient presentations in the emergency department for respiratory complaints, with many of these patients requiring ICU admission and…
- Trial name
- NO COV-ED (NCT04338828)
- Testing
- Nitric Oxide Gas, Inhaled Supplemental Oxygen
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Massachusetts General Hospital
Aspiration Pneumonia
Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
The two most common consequences resulting from aspiration are chemical pneumonitis and bacterial aspiration pneumonia. Both entities present with comparable clinical signs and symptoms.
- Trial name
- APAPI (NCT03763799)
- Testing
- PCR-based microbiological diagnosis strategy, Standard microbiological diagnosis strategy
- Where
- 2 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Lille
PET/CT, COVID-19
Study for Quantitative Analysis of the Recovered COVID-19 Patients by 18F-FDG-PET/CT
In this study, clinically cured patients with severe COVID-19 were used to evaluate the therapeutic effect of COVID-19 and the recovery and health status of patients over time with highly sensitive PET/CT imaging technology.
- Conditions
- PET/CT, COVID-19, Respiratory Function, Inflammatory Lesions
- Trial name
- NCT04519255
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Corona Virus Infection, Pneumonia
COVID-19 Specific T Cell Derived Exosomes (CSTC-Exo)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused mass mortality in the last 3 months that necessitates urgent development of new therapeutical agents.
- Trial name
- NCT04389385
- Testing
- COVID-19 Specific T Cell derived exosomes (CSTC-Exo)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Pneumonia, Interstitial, Cancer Patients
Study of of Oxygen Nebulized Inhalation EGCG in Cancer Patients With New Coronary Pneumonia
Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions, such as anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects via modulation of a…
- Trial name
- NCT06924749
- Testing
- EGCG
- Where
- 2 sites in China
- Volunteers
- 111 people
- Sponsor
- Shandong Cancer Hospital and Institute
Postoperative Pulmonary Complications (PPCs), Cardiac Surgery With Sternotomy
Effect of Positioning and ACBT on Pulmonary Complications After Cardiac Surgery
The goal of this quasi-experimental clinical trial is to learn if position management combined with the Active Cycle of Breathing Techniques (ACBT) works to reduce postoperative pulmonary complications in adult patients…
- Conditions
- Postoperative Pulmonary Complications (PPCs), Cardiac Surgery With Sternotomy, Atelectasis, Postoperative Pneumonia
- Trial name
- P-ACBT (NCT07612033)
- Testing
- Structured Position Management Protocol, Active Cycle of Breathing Techniques (ACBT)
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Assiut University
Respiratory Infection, Bacterial Resistance
Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit
The purpose of this study was : to determine the effect of inhaled antibiotics on airway bacteria in ventilated patients to determine the effect of inhaled antibiotics on respiratory infection
- Conditions
- Respiratory Infection, Bacterial Resistance, Respiratory Failure
- Trial name
- NCT01878643
- Testing
- vancomycin or gentamicin
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Stony Brook University
Dysphagia, Respiratory Tract Infections
Using Plain Water With Oral Care to Increase Hydration for Long Term Care Residents With Disordered Swallowing
The Frazier Free Water Protocol (FFWP) using plain, thin (unmodified) water is an accepted method to increase fluid intake and hydration in older adults with disordered swallowing and dementia.This study aims to take an…
- Trial name
- FFWP (NCT03672552)
- Testing
- FFWP and Improved Oral Care
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Memorial University of Newfoundland
Esophageal Resection Candidates
Preoperative Inspiratory Muscle Training in Esophageal Resection
The PREPARE study is the first multicenter randomized controlled trial to evaluate the hypothesis that preoperative inspiratory muscle training leads to decreased pulmonary complications in patients undergoing esophageal…
- Trial name
- PREPARE (NCT01893008)
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- 9 sites in Belgium, Finland and 2 more
- Volunteers
- 245 people
- Sponsor
- UMC Utrecht
Chronic Obstructive Pulmonary Disease
Microbiome Use to Stratify Use of Inhaled Corticosteroids: MUSIC Trial
A randomised controlled trial to test the hypothesis that inhaled therapies for chronic obstructive pulmonary disease (COPD) have differential effects on the upper airway microbiome.
- Trial name
- MUSIC (NCT02972476)
- Testing
- Budesonide & formoterol fumarate and Aclidinium bromide, Fluticasone 500 & salmeterol and Aclidinium bromide, Fluticasone 250 & salmeterol and Aclidinium bromide
- Where
- 6 sites in United Kingdom
- Volunteers
- 158 people
- Sponsor
- University of Dundee
COVID-19, SARS-CoV2 Infection
Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol
This is a phase 1 study in healthy volunteers who have received at least three doses of an mRNA COVID-19 vaccine, to evaluate the safety and immune responses that develop in the blood and lungs following the administration by…
- Trial name
- NCT05094609
- Testing
- Ad5-triCoV/Mac, ChAd-triCoV/Mac
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Radiation Pneumonitis
Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients
This randomized clinical study aims to assess whether prophylactic treatment with inhaled steroids in patients with locally advanced or concomitantly treated non-small cell lung carcinoma who are candidates for combination…
- Trial name
- NCT03803787
- Testing
- Inhaled budesonide
- Where
- 2 sites in Mexico
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Nitric Oxide, COVID-19
Inhaled NO in Surgical Patients With Recent COVID-19 Infection
The aim of this study is to evaluate the effect of perioperative inhalation of NO on reducing the incidence of postoperative pulmonary complications in patients with recent COVID-19 infection, and to evaluate whether inhaled NO…
- Conditions
- Nitric Oxide, COVID-19, Surgery, Postoperative Complications
- Trial name
- INORDINATE (NCT05721144)
- Testing
- Nitric Oxide Gas
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Xijing Hospital
Tracheobronchitis, Pneumonia
Tracheobronchitis Prevention Trial
We aim to study whether the use of inhaled antibiotics may have an impact on the incidence of tracheobronchitis and pneumonia associated with the use of mechanical ventilation.
- Trial name
- TRAMA (NCT01025921)
- Testing
- colistin (Tadim), inhaled normal saline
- Where
- Greece
- Volunteers
- 84 people
- Sponsor
- University of Thessaly
Inhalation Pneumonia
Effect of Diluent Volume on Colistin Inhalation Therapy
The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy.
- Trial name
- NCT06230614
- Testing
- Colistin 1 MU in normal saline 1 ml, Colistin 1 MU in normal saline 2 ml
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University
COVID-19
Inhaled Nitric Oxide for Preventing Progression in COVID-19
This is a pilot randomized-controlled (2:1) open label investigation of inhaled NO to prevent progression to more advanced disease in 42 hospitalized patients with COVID-19, at risk for worsening, based on baseline systemic…
- Trial name
- NO-COVID-19 (NCT04388683)
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts Medical Center