Clinical trials: Inhalation Pneumonia
Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome)
The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics
The goal of this interventional study is to evaluate the effect of different positive end-expiratory pressures (PEEP) on lung and diaphragm function in patients mechanically ventilated with pressure support ventilation in the…
- Conditions
- Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome), Pneumonia, Respiratory Insufficiency
- Trial name
- INFLATE-ICU (NCT07188038)
- Testing
- Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure
- Where
- 2 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Vastra Gotaland Region
Pneumonia, Pneumocystis Carinii, HIV Infections
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
To compare the safety and effectiveness of drug therapy with aerosolized pentamidine (PEN) with that of conventional therapy, sulfamethoxazole plus trimethoprim (SMX/TMP) in the treatment of Pneumocystis carinii pneumonia (PCP)…
- Trial name
- NCT00000715
- Testing
- Pentamidine isethionate, Sulfamethoxazole-Trimethoprim
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COPD, Congestive Heart Failure
Enhancing Utilization of Non-Invasive Positive Pressure Ventilation in Critical Care
Non-invasive positive pressure ventilation (NIV) refers to the provision of mechanical ventilation without an artificial airway (for example, an endotracheal tube).
- Conditions
- COPD, Congestive Heart Failure, Asthma, Respiratory Distress Syndrome, Adult
- Trial name
- NCT00458926
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Tufts Medical Center
Covid19, Pneumonia, Viral
Inhalation Low Dose Radionuclide Therapy in Treatment COVID-19
Coronavirus disease (COVID-19) is a pandemic of unprecedented proportions with an exponential increase in incidence. Airway epithelium infection caused by coronavirus (SARS-CoV-2) triggers a cascade of difficult-to-control…
- Trial name
- NCT04724538
- Testing
- 99mTc-pertechnetate aerosol
- Where
- Russia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Medical Research Radiological Centre of the Ministry of Health of Russia
COVID-19
Evaluation of Safety & Efficacy of MIR 19 ® Inhalation Solution in Patients With Mild COVID-19
The aim of this study is to evaluate the effectiveness and safety of MIR 19 ® in preventing development of moderate and/or severe course of the disease in mild COVID-19 outpatients.
- Trial name
- NCT05783206
- Testing
- MIR 19 ®, Standard therapy
- Where
- Russia
- Volunteers
- 984 people
- Sponsor
- National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
Pneumonia, Pleural Effusion
Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation
The objective of this study is to assess whether there is a difference between a care protocol with the use of incentive spirometry (Voldyne ®) and another with the application of NIV (non invasive ventilation with single-level…
- Conditions
- Pneumonia, Pleural Effusion, Atelectasis
- Trial name
- NCT01416519
- Testing
- Continuous Positive Airway Pressure (CPAP) facial mask, Assisted deep inspiration technique
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Santa Casa de Votuporanga
Post COVID-19
Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults
When the literature search is conducted, it is seen that there are many studies examining the effects of COVID-19 disease on individuals in various disease groups (MS, stroke, Parkinson, COPD, asthma, etc.) and age groups (adult…
- Trial name
- PEPICov (NCT05282043)
- Testing
- Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Acute Respiratory Distress Syndrome, Sepsis
Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
This study is a multi-center, randomized, partially double-blind, and placebo-controlled Phase Ib clinical trial of inhaled CO (iCO) for the treatment of sepsis-induced acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04870125
- Testing
- Inhaled Carbon Monoxide at CFK equation-determined personalized dose (200-500 ppm to achieve a COHb level of 6-8%), Inhaled Medical air
- Where
- 6 sites in United States
- Volunteers
- 5 people
- Sponsor
- Brigham and Women's Hospital
Chronic Obstructive Pulmonary Disease, Asthma
Evaluation of ST2 and IL-33 in Patients Presenting to the Emergency Department With Trouble Breathing
Trouble breathing (dyspnea) is a nonspecific symptom associated with many diseases such as chronic obstructive pulmonary disease (lung disorder in which the flow of air to the lungs is blocked), asthma, pneumonia, pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Pulmonary Embolism, Pneumonia
- Trial name
- NCT00707811
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- The Cleveland Clinic
Aspiration Pneumonia, Tracheostomy
Continuous Enteral Feeding Until Tracheostomy and Aspiration Risk
This prospective observational study evaluates whether continuing enteral feeding until tracheostomy affects aspiration pneumonia risk and early clinical outcomes in mechanically ventilated intensive care unit patients undergoing…
- Conditions
- Aspiration Pneumonia, Tracheostomy, Mechanical Ventilation
- Trial name
- NCT07508293
- Testing
- Continuous enteral feeding, Fasting
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Clinical Infection, Outcome
Efficacy and Safety of Ethanol Inhalation on COVID-19 Treatment (a Clinical Trial Study)
Cytokine storm is the cause of many deaths in COVID -19. The antiviral in-vitro effects of ethanol with solving the fat layer and destroying the glycoprotein of coronavirus have already been established.
- Conditions
- Clinical Infection, Outcome, Morality
- Trial name
- COVID-19 (NCT05268419)
- Testing
- Ethanol, Water Distilled
- Where
- Iran
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ali Amoushahi
Covid19
FLuticasone in cOvid Treatment (FLOT)
A multicenter, open-label, randomized controlled trial to evaluate the efficacy of fluticasone propionate (metered dose inhaler - MDI) added to standard care at early stage of COVID-19 in reducing the incidence of adverse…
- Trial name
- FLOT (NCT05054322)
- Testing
- Fluticasone Propionate
- Where
- Vietnam
- Volunteers
- 500 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Covid19, Severe Systemic Illness Respiratory Muscle Fatigue
The Effects of Multi-modality Physiotherapy in Delaying or Preventing COVID-19 Patient From Admitting to ICU
This study aims to evaluate the effectiveness of respiratory muscle training with COVID-19 patient, who has underlying health conditions, in order to delay or prevent them from admitting to ICU.
- Trial name
- NCT04617119
- Testing
- Threshold IMT device, Conventional physical therapy
- Where
- Kuwait
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- DR. JASSIM ALGHAITH
Critical Illness, Length of Stay
Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients
The purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.
- Conditions
- Critical Illness, Length of Stay, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT00466492
- Testing
- Sedation or no sedation during mechanical ventilation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
COVID-19
A Dose Escalation Phase 1 Study Evaluating the Safety and Pharmacokinetics of an Inhaled COVID-19 Inhibitor Delcetravir in Healthy Subjects
This study will be a single center, Phase I, randomized, double-blind, placebo controlled, single and multiple ascending dose (SAD/MAD) study evaluating the safety, tolerability, and PK of Delcetravir after administration via…
- Trial name
- NCT05453279
- Testing
- Delcetravir dry powder inhaler
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Esfam Biotech Pty Ltd
Pneumonia, Ventilator-Associated
Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia
The objective of the study is to prove that after the third day of invasive mechanical ventilation a three-day course of inhaled amikacin reduces the incidence of subsequent VAP.
- Trial name
- AMIKINHAL (NCT03149640)
- Testing
- Inhaled amikacin
- Where
- 18 sites in France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Tours
Corona Virus Infection
Effect of Active Cycle Breathing Technique Along With Incentive Spirometer on COVID19 Patient
this study will be conducted to investigate the effect of Active Cycle Breathing Technique and incentive spirometer on COVID19 patient
- Trial name
- COVID19 (NCT05517941)
- Testing
- active cycle breathing, incentive spirometer
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Covid19
Safety of Ascending Doses of Niclosamide (UNI911 INHALATION) in Healthy Volunteers
This is a Phase 1 Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess the Safety of Ascending Doses of UNI911 INHALATION in Healthy Volunteers in Preparation for Evaluation in Adults with COVID-19
- Trial name
- NCT04576312
- Testing
- UNI911 inhalation 1% and intranasal spray 1%
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- UNION therapeutics
COVID-19
Effects of Unsupervised Inspiratory Muscle Training on Ventilation Variability in Post-covid-19 Patients.
Dysfunctional breathing and persistent hypocapnia can be associated with many of the symptoms experienced by patients such as dyspnea, fatigue, chest pain and palpitations.
- Trial name
- NCT06362499
- Testing
- Experimental Group
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Respiratory Tract Infections, Corona Virus Infection
Inhaled Gaseous Nitric Oxide (gNO) Antimicrobial Treatment of Difficult Bacterial and Viral Lung (COVID-19) Infections
Non tuberculous mycobacteria (NTM), Burkholdria spp, Aspergillus in the lung are almost impossible to eradicate with conventional antibiotics. In addition COVID-19 has know current treatment.
- Trial name
- NCT03331445
- Testing
- Nitric Oxide 0.5 % / Nitrogen 99.5 % Gas for Inhalation
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Chris Miller