Clinical trials: Inherited Cardiac Conduction Disorder
Brugada Syndrome
European Perioperative Brugada Survey
The aim of this survey is to assess the current perception and clinical practice of Resident and Board-certified Anaesthesiologists and Intensivists regarding perioperative care of patients burdened with the Brugada Syndrome.
- Trial name
- NCT04808193
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Long QT Syndrome, Sudden Cardiac Death
Electromechanical Profiling of the Long-QT Syndrome (LQTS)
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
- Conditions
- Long QT Syndrome, Sudden Cardiac Death, Ventricular Tachycardia
- Trial name
- EMLoQ (NCT04074122)
- Testing
- Adenosine and epinephrine, isoprenaline provocation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias
The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia.
- Conditions
- Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1, Catecholaminergic Polymorphic Ventricular Tachycardia Type 2
- Trial name
- ACTIVELY (NCT06661278)
- Testing
- Exercise tolerance test, Physical activity & heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Healthy, Long QT Syndrome
Study Evaluating the Effects of Multiple Oral Doses of ERB-041 on Cardiac Repolarization in Healthy Subjects
To assess the effect of ERB-041 after multiple oral doses on cardiac repolarization as assessed by the QTc interval.
- Trial name
- NCT00316459
- Testing
- ERB-041
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Long QT Syndrome
Phase 1 Study of LQT-1213 in Healthy Adults
This is a single-center, randomized, double-blind, placebo-controlled study to be conducted in 2 parts: single ascending dose (SAD) incorporating a food effect arm and multiple ascending dose (MAD).
- Trial name
- NCT05759962
- Testing
- LQT-1213
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Brugada Syndrome
Right Ventricle Morphology and Hemodynamics in BrS
The study purpose is to evaluate the morphological, functional and electrophysiological characteristics of the right ventricle before and after ajmaline in patients diagnosed with Brugada syndrome as well as to correlate CMR…
- Trial name
- RV-BrS (NCT03524079)
- Testing
- Ajmaline 17-(Chloroacetate) Monohydrochloride
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Long QT Syndrome, Hypoglycemia
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism
The human ether-a-go-go-related gene HERG (encoding Kv11.1 potassium channels) is expressed in different parts of the body including the heart, pancreas and intestines.
- Trial name
- NCT03868657
- Testing
- Moxifloxacin
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pregnancy, Long QT Syndrome
Ventricular Repolarization During the Pregnancy-to-Postpartum Transition (QuTe)
Pregnancy and the postpartum period are accompanied by marked changes in heart rate, circulating hormones, and electrolyte balance that may influence ventricular repolarization.
- Trial name
- QuTe (NCT02931695)
- Testing
- Evaluation of QT interval duration, Circulating sex hormones levels sample
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Sensorineural Hearing Loss, Long QT Syndrome
Determine the Incidence of Long QT Amongst a Large Cohort of Subjects Diagnosed With Unilateral or Bilateral Sensorineural Hearing Loss.
The purpose of this study is to determine the true incidence of long QT (LQT) amongst a large cohort of subjects diagnosed with unilateral (right/left) or bilateral sensorineural hearing loss.
- Trial name
- NCT02082431
- Where
- 12 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm
Fetal and Neonatal Magnetophysiology
Fetal research and clinical practice has been hampered by a lack of suitable investigational techniques. Currently, ultrasound is the only widely used method of studying fetal anatomy and physiology, but it has significant…
- Conditions
- Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm, Long QT Syndrome
- Trial name
- NCT01903564
- Testing
- magnetocardiography, postnatal ECG, fetal echocardiography
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment
"Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients"
"This study aims to investigate ultrasonographic parameters of the median nerve in healthy individuals and patients with mild and moderate carpal tunnel syndrome (CTS).
- Conditions
- Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment, Electrophysiologic Study, Ultrasound
- Trial name
- NCT07408596
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Long QT Syndrome
KCNQ1 Cascade Screening
The objectives of the protocol are to: (1) evaluate the uptake of cascade screening and preventative therapies after the implementation of a simplified screening process and (2) assess proband and family member perspectives about…
- Trial name
- NCT03783975
- Testing
- Simplified Cascade Screening
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Long QT Syndrome
Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2).
Part 1: This is a Phase 1b, randomized, double-blind, crossover, dose escalation, placebo-controlled study to evaluate the effect of oral LQT-1213 on dofetilide-induced QTc prolongation in healthy adult subjects.
- Trial name
- NCT05906732
- Testing
- LQT-1213, Dofetilide 250 μg Cap
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Long QT Syndrome
Long QT Syndrome Screening in Newborns
The purpose of this project is to test a new, very compact, 12-lead ECG device as a way to detect long QT syndrome (LQTS) in infants. The device -- called QTScreen -- was developed in Phase I of this project.
- Trial name
- NCT02412709
- Testing
- QTScreen ECG Recorder
- Where
- 3 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- QT Medical, Inc.