Clinical trials: Injection Site Pain
Injection Site Haematoma, Local Anesthetic Toxicity
U/S Guided SAPB Versus Conventional IV Analgesics in Postoperative Pain Management in MRM
The aim of this study is to compare the effect of ultra-sound guided serratus anterior plane block versus conventional IV analgesics in postoperative pain management in modified radical mastectomy (MRM)
- Trial name
- SAPB (NCT05126394)
- Testing
- ultrasound guided serratus anterior plane block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia; Hypothermia, Injection Site Irritation
Topical Ice-therapy for Intravitreal Injections
Purpose: To examine the difference in patient's pain experience in the setting of intravitreal anti-VEGF injections with pretreatment of topical ice-therapy compared with no-ice.
- Trial name
- NCT05269823
- Testing
- Ice-therapy, No Ice-therapy
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain
The Effects of Injection Site Cooling and Solution Buffering on Perceived Pain During Local Anesthesia Administration
Participants will have local anesthesia administered to the palmar aspect of both forearms using 4 different injection methods in order to determine which method provides the best results in terms of perceived pain, overall…
- Trial name
- NCT04991597
- Testing
- Cold Compress Pack, Room Temperature Compress Pack, Lidocaine Epinephrine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nicholas Bastidas
Pain, Injection Site
Adalimumab Microneedles in Healthy Volunteers
Adalimumab (Humira, AbbVie) is a highly effective treatment for a variety of auto-immune/auto-inflammatory diseases including juvenile idiopathic arthritis (JIA).
- Trial name
- NCT03607903
- Testing
- Adalimumab ID, Adalimumab SC, Saline ID
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
Pain, Quality of Life
Simultaneous RZV and aIIV4 Vaccination
The overall aim of the study is to compare the safety of simultaneous Zoster Vaccine Recombinant, Adjuvanted (RZV) (SHINGRIX®) and Quadrivalent Influenza Vaccine, Adjuvanted (FLUAD®) versus simultaneous Zoster Vaccine…
- Conditions
- Pain, Quality of Life, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05007041
- Testing
- FLUAD® Quadrivalent, Fluzone® High-Dose Quadrivalent, SHINGRIX®
- Where
- 2 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Duke University
Carpal Tunnel Syndrome, De Quervains Tenosynovitis
The SToICAL Study - The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study
Some hand conditions can be treated with a steroid injection. Some doctors mix the steroid with local anaesthetic in the hope that the patient will experience less pain after the injection. Some doctors do not do this.
- Conditions
- Carpal Tunnel Syndrome, De Quervains Tenosynovitis, Trigger Finger
- Trial name
- SToICAL (NCT04253457)
- Testing
- 1ml of triamcinolone (40mg/1ml)
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Osteoarthritis, Knee
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee
A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.
- Trial name
- NCT03472677
- Testing
- Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Anesthesia, Local, Infiltration
A Trial Comparing Pain During Local Tumesent Injection In Fingers Using Different Syringe-Needle Combinations
Background: This study aims to obtain the most favorable syringe and needle combination, which causes the least pain during local anesthesia tumescent injection in the simulation of fully awake hand surgery.
- Conditions
- Anesthesia, Local, Infiltration, Injection Site, Pain
- Trial name
- NCT03736915
- Testing
- Injection using 1 cc of NaCl 0.9%, Patient Preference Question, Questionnaires
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Healthy
Study of Ixekizumab in Healthy Participants
The purpose of this study is to compare the tolerability of injections of each of 3 formulations of ixekizumab using a prefilled syringe.
- Trial name
- NCT03848403
- Testing
- Ixekizumab
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Pain
Intravitreal Injection Site and Perceived Pain
The objective of this study is to explore the perception of pain during intravitreal injection related to the distance of the entry site from the limbus.
- Trial name
- NCT05640895
- Testing
- Intravitreal injection site
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Pain, Acute, Injection Site
Effect of Different Subcutaneous Injection Methods on Pain and Satisfaction
This study; In patients treated with subcutaneous heparin A randomized controlled trial was planned to determine the effect of the injection time and the device called "Palm Stimulator" to reduce the pain felt during injection.
- Trial name
- NCT06829407
- Testing
- injection time, palm stimulator, injection time and palm stimulator
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Trakya University
Healthy Volunteers Diabetes Mellitus, Type 2, Healthy Volunteers Overweight
A Study Comparing the Injection Site Pain Experience After the Injection of Semaglutide B and Semaglutide D With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity
This study in healthy men and women looks at the injection site experience of the DV3396 pen to that of the PDS290 pens when both pens are used to deliver 0.25 mg semaglutide subcutaneously (s.c., under the skin).
- Conditions
- Healthy Volunteers Diabetes Mellitus, Type 2, Healthy Volunteers Overweight, Healthy Volunteers Obesity
- Trial name
- NCT04143945
- Testing
- Semaglutide (administered by DV3396 pen), Semaglutide (administered by PDS290 pen)
- Where
- Netherlands
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Injection Site
Efficacy of TEAS On Prevention of Propofol Injection Pain in Children
The purpose of this study is to determine the efficacy of transcutaneous electrical acupoint stimulation for the prevention of propofol injection pain in children.
- Trial name
- NCT05296187
- Testing
- TEAS
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Healthy Volunteers, Diabetes Mellitus, Type 2
Comparison of Injection Site Pain Experience for Semaglutide and Dulaglutide sc
This study in healthy men and women looks at the injection site experience of semaglutide and dulaglutide given subcutaneously (s.c., under the skin).
- Conditions
- Healthy Volunteers, Diabetes Mellitus, Type 2, Overweight, Obesity
- Trial name
- NCT04189848
- Testing
- Semaglutide, Dulaglutide
- Where
- Netherlands
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Injection Site Irritation
Effect of Esmolol on Pain Due to Rocuronium
90 American society of anesthesiology (ASA) physical status I and II patients undergoing general anesthesia for elective surgery will be included in the study. Patients will be randomized into three groups.
- Trial name
- NCT01824758
- Testing
- Lidocaine, Esmolol, rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Breast Reconstruction
Pain Study Using Intermittent Bupivacain Injections After Breast Reconstruction With DIEP Flap
patients are given bupivacain intermittent locally on the donor site after brest reconstruction with diep flap. The hypothesis was that this approach will reduce the need for rescue analgetic medication and pain perception within…
- Trial name
- NCT00804674
- Testing
- bupivacain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Muscle Pain, Injection Site Pain
Effects of TPR and Z Techniques on Pain and Drug Leakage in Intramuscular Injections
This randomized, triple-blind clinical trial compares the effectiveness of Z-track and TPR (traction-pressure-release) techniques in reducing pain and medication leakage during ventrogluteal intramuscular injections.
- Trial name
- TPR_Z_PainLeak (NCT07004166)
- Testing
- Z-track method, TPR method
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Injection Site Irritation, Fear of Pain
Virtual Reality, Ice Application and Self-injection and Self-test Fair, Pain and State Anxiety
AİM:The aim of this study is to control the fears and anxieties of Type 2 diabetics in insulin injection and blood glucose measurement with motivational videos and Ice applications to be applied with virtual reality glasses.
- Trial name
- NCT04436666
- Testing
- motivational video production through virtual reality glasses, Ice Application
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Inonu University
Pain, Procedural, Acute Pain
IM İnjection-PAIN-Cold Spray and Stress Ball
Brief Summary: Intramuscular (IM) injection is a widely used method for drug administration, with over 12 billion applications globally each year.
- Conditions
- Pain, Procedural, Acute Pain, Injection Site
- Trial name
- CSB-PAIN (NCT07233694)
- Testing
- cold spray gruop, stress ball gruop
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Erzincan Binali Yildirim Universitesi
Injection Site Bruising, Bruising
Cold Application on the Subcutaneous Injection
The goal of this clinical trial is to compare the effect of cold application at different periods of time on the occurrence of bruising, haematoma and pain in the subcutaneous low molecular weight heparin (LMWH) injected patients.
- Conditions
- Injection Site Bruising, Bruising, Pain
- Trial name
- NCT05771285
- Testing
- Cold application
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yuksek Ihtisas University