Clinical trials: Injections
Knee Osteoarthritis
Ketorolac Versus Triamcinolone Knee Injections for Osteoarthritis
Osteoarthritis is a disabling disease of the joint spaces and has a high impact on society due to the amount of people who are affected by the disease. Nonoperative management is a mainstay of therapy in most patients.
- Trial name
- NCT02295189
- Testing
- Ketorolac Tromethamine, Triamcinolone Acetonide
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
Nasal Polyps
Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS
This study aimed to show the effect of sphinopalatine ganglion blockade on surgical field, hemodynamics and postoperative pain in FEES operation.
- Trial name
- NCT04996576
- Testing
- infrazygomatic approach sphinopalatine ganglion block, intranasal injection approach of sphinopalatine ganglion block
- Where
- 2 sites in Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Characteristics of Subcutaneous Fat
ATX-101 Abdominoplasty
Histopathological study of abdominal fat excised from subjects undergoing abdominoplasty
- Trial name
- ATX-101-08-10 (NCT00835952)
- Testing
- ATX-101
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Total Knee Arthroplasty
Single-injection Adductor Canal Block for Total Knee Arthroplasty Under Spinal Anesthesia
This study evaluates the effect of the single-injection adductor canal block in patients receiving total knee arthroplasty under spinal anesthesia.
- Trial name
- NCT04400708
- Testing
- adductor canal block, control group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Tinnitus
Evaluation of Adding Lidocaine to Dexamethasone in Intra-tympanic Injection for Management of Tinnitus
Importance; Tinnitus is a heterogeneous diagnosis that may occur alone, in the presence of hearing loss or as a component of other disorders and can be quite disabling.
- Trial name
- tinnitus (NCT03265197)
- Testing
- Intra-tympanic injection of drugs, Data management of intratympanic drugs
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- saad elzayat
Cicatrix
Scar-Improvement Efficacy and Safety of a Single Intradermal Injection of Avotermin (Juvista) Administered Following Full-Thickness Skin Incisions
This study was undertaken to investigate the scar-improvement efficacy and safety of a single dose of avotermin (Juvista) injection into skin incisions.
- Trial name
- NCT00627536
- Testing
- Avotermin
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Renovo
Healthy
A Study of Mirikizumab in Healthy Participants
The main purpose of this study is to compare the amount of mirikizumab that gets into the blood stream and how long it takes the body to get rid of it, when given as a solution formulation via manual prefilled syringe or…
- Trial name
- NCT04607733
- Testing
- Mirikizumab Prefilled Syringe, Mirikizumab Autoinjector
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Jet Injection, Local Anasthesia
This Study Evaluate the Patient Response to Jet Injection, Pain and Satisfaction Compared to Conventional Method of Local Anasthesia Especially in Maxillary Teeth
Pain during administration of local anesthesia remains one of the major concerns in dental practice, often leading to anxiety and treatment avoidance.
- Trial name
- NCT07581249
- Testing
- Non aspirating dental syringe, The use of jet injection
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Colorectal Polyp
ORISE Study: Evaluation of Novel Injecting Solution (ORISE) During Endoscopic Resection of Colorectal Polyps.
Is ORISE Gel an effective and feasible submucosal injecting solution during endoscopic resection of large colorectal polyps.
- Trial name
- ORISE (NCT04886609)
- Testing
- ORISE gel
- Where
- 5 sites in Italy, United Kingdom
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Neutropenia (Low White Blood Cell Count)
A Research Study To Test How Filgrastim Hospira Works In The Body Of Healthy Study Subjects When Given By Subcutaneous Injection (Shot) Compared To An Already U.S.-Approved Drug Neupogen® (Amgen)
This is a study comparing two study drugs, Filgrastim Hospira and Neupogen®. Neupogen® is approved by the US Food and Drug Administration (FDA) to treat low numbers of specific kinds of white blood cells (WBC) known as…
- Trial name
- NCT02766647
- Testing
- Filgrastim Hospira (US), US-approved Neupogen®
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Weight Management
A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Combination With Semaglutide
This will be a phase I, randomized, double-blind, placebo-controlled. This study will be conducted in three periods: the screening period, the treatment period, and the follow-up period.
- Trial name
- NCT06972992
- Testing
- ASC47 +Semaglutide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharma (China) Co., Limited
Pharmacokinetics and Pharmacodynamics
Comparison of the Pharmacokinetics （PK）and Pharmacodynamics （PD）Biosimilarity of Insulin Aspart Injections After Single-Dose Subcutaneous Administration to Healthy Volunteers
The present study is designed to compare the pharmacokinetic, pharmacodynamic and safety characteristics of UBLIN® (test product) and NovoRapid® (reference product) in healthy male participants.
- Trial name
- NCT07600944
- Testing
- Insulin Aspart Injection（UBLIN®）, Insulin Aspart Injection（NovoRapid®）
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Zhuhai United Laboratories Co., Ltd.
Anesthesia
Diaphragmatic Dysfunction After Ultrasound-guided Supraclavicular Block With Single or Double Injection Technique
The investigators plan to determine the incidence of hemi-diaphragmatic paresis (HDP) with two commonly used techniques of supraclavicular nerve block, the single and double injection techniques.
- Trial name
- NCT02795598
- Testing
- Single injection supraclavicular nerve block, Double injection supraclavicular nerve block
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Healthy Volunteers
Single-Dose Study of MT203
The purpose of this study is to evaluate safety, pharmacokinetics and pharmacodynamics of single subcutaneous injection of MT203 in healthy adult Japanese and Caucasian male participants.
- Trial name
- NCT02354599
- Where
- Japan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Takeda
Rotator Cuff Tendinitis
Study of 25% Dextrose Injections in Shoulder Ligaments and Tendons to Promote Their Healing
HYPOTHESIS: Prolotherapy, the injection of a growth promoting solution in injured ligaments and tendons of the shoulder is an effective treatment that decreases pain, increases functional capacity and promotes healing better and…
- Trial name
- Prolotherapy (NCT01402011)
- Testing
- 25% dextrose in shoulder entheses, .1% lidocaine in shoulder entheses, .1% lidocaine subcu. above shouldr enth.
- Where
- 2 sites in Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Infertility
Local Uterine Application of Low Molecular Weight Heparin (LMWH) in Intra-cytoplasmic Sperm Injection (ICSI)
Heparin also has the ability to bind with and modulate a wide variety of proteins, which can influence a number of physiological processes involved in implantation \& trophoblastic development.
- Trial name
- NCT02325479
- Testing
- Enaoxaprin sodium, tissue culture media
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Egyptian IVF-ET Center
Local Anesthesia
Effectiveness of Sodium Bicarbonate Buffered Anaesthetic Solution on Pain During Injection
This study will test the effectiveness of addition of Sodium Bicarbonate as a buffering agent to the anaesthetic solution on minimizing the pain of injection and increasing the onset time and potency of the anaesthetic solution…
- Trial name
- NCT05473819
- Testing
- Buffered Local Anesthesia, Conventional Unbuffered Local Anesthesia
- Where
- Egypt
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Hemodynamic Instability
Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery
During endoscopic sinus surgery (ESS), epinephrine local injection and controlled hypotension is essential in order to increase the visibility in the operative field and reduce the risk.
- Trial name
- NCT02464722
- Testing
- Dexmedetomidine, Remifentanil, Epinephrine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Healthy
A Study Comparing User Experience of Different Delivery Devices for Glucagon
The purpose of the study is to learn more about different devices for delivering glucagon during simulations of severe hypoglycemic (low blood sugar) emergencies.
- Trial name
- NCT03765502
- Testing
- Nasal Glucagon Device (NG), GEK, IM Glucagon
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Pain
Pain Perception: Lidocaine Rate/Temp/Buffer
This study will collect data from multiple academic institutions. The primary objective for part A of this study is to determine the impact of anesthetic injection rate and temperature on pain perception during dermatologic…
- Trial name
- NCT02823002
- Testing
- Slow, Room Temperature Injection, Rapid, Room Temperature Injection, Slow, Warm Temperature Injection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Northwestern University
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