Clinical trials: Injections
Bioequivalence, Healthy Volunteers
Bioequivalence Clinical Trial of Recombinant Human Follicle-stimulating Hormone JZB30
Research Objective: Using the recombinant human follicle-stimulating hormone injection (Gonal-f®) originally developed by Merck Serono as the reference formulation, and the recombinant human follicle-stimulating hormone injection…
- Conditions
- Bioequivalence, Healthy Volunteers, Pharmacokinetics, Safety
- Trial name
- NCT06778304
- Testing
- Gonal F, jzb30
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital
Injection Fear, Injection Site Coldness
Coolsense and Buzzy Use on Pain Score and Anxiety Level During Insulin Injection Application
This study aims to determine the effect of using Coolsense, which is created using the proven effect of cold application during insulin injection, and Buzzy, which is a combination of vibration and cold application, in reducing…
- Conditions
- Injection Fear, Injection Site Coldness, Pain, Type 1 Diabetes Mellitus
- Trial name
- NCT06369649
- Testing
- Coolsense and Buzzy
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
HIV (Human Immunodeficiency Virus)
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of LP-98 Injection in Healthy Subjects
A randomized, placebo-controlled, single-administration, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of LP-98 injection in healthy subjects in a first-in-human clinical study
- Trial name
- NCT05933824
- Testing
- LP-98 injection
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shanxi Kangbao Biological Product Co., Ltd.
Healthy Volunteers, Obesity
Phase 1 Clinical Study of MWN117 Injection in Healthy Participants and Participants With Obesity
This study is a randomized, double-blind, placebo-controlled, single-dose, dose-escalation Phase 1 clinical trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MWN117 injection in healthy and…
- Trial name
- NCT07824804
- Testing
- MWN117
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Knee Osteoarthritis
Ketorolac Versus Triamcinolone Knee Injections for Osteoarthritis
Osteoarthritis is a disabling disease of the joint spaces and has a high impact on society due to the amount of people who are affected by the disease. Nonoperative management is a mainstay of therapy in most patients.
- Trial name
- NCT02295189
- Testing
- Ketorolac Tromethamine, Triamcinolone Acetonide
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
Vocal Cord Paralysis
Voice Rest and Injection Laryngoplasty
The purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.
- Trial name
- NCT05542550
- Testing
- Voice Rest, No Voice Rest
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Nursing, Injection Site
Necessity of Aspiration in the Ventrogluteal Site
H1: Aspiration is not necessary for IM injections applied from the ventrogluteal region. H2: Aspiration procedure increases pain in IM injections applied from ventrogluteal region.
- Trial name
- NCT04421599
- Testing
- The Necessity of Aspiration
- Where
- Turkey (Türkiye)
- Volunteers
- 834 people, healthy volunteers welcome
- Sponsor
- Ege University
Skin Abnormalities
Fractional Co2 Laser Versus Microbotox Injection in the Treatment of Wide Facial Pores: A Split Face Comparative Study
1. Evaluation of fractional Co2 laser as a treatment option for wide pores in skin type (III - VI) 2. Evaluation of mesobotox as a new modality for improving wide pores appearance. 3.
- Trial name
- NCT05923996
- Testing
- microbotox, fractional carbon dioxide laser
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Assiut University
Palatally Impacted Canines
Efficacy of Injectable Vitamin C on Accelerating Canine Movement: A Clinical Study
efficacy of the injectable vitamin C to reduce the time of canine traction
- Trial name
- mesotherapy (NCT03260829)
- Testing
- vitamin C
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lymph Nodes
Inguinal and Axillary LN Size Distribution
Recently, intralymphatic allergen-specific immunotherapy (ILIT) showed promising treatment outcomes for allergic rhinoconjunctivitis.
- Trial name
- NCT06559202
- Testing
- chest and abdominoplevic CT
- Where
- South Korea
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Dental Anesthesia
Clinical Evaluation and Comparison of Pain Acceptance of Different Types of Injection Systems
The goal of this randomized clinical trial is to compare two different injection methods in children. The main question it aims to answer is: Is the needle-free injection method more painless than the traditional dental method?…
- Trial name
- NCT06892873
- Testing
- Comfort-In, Traditional dental injection
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Fibromatosis
A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors
There is research supporting treatment of superficial fibromatoses (palmar fibromatosis and keloids) with triamcinolone acetonide injections. These lesions are histologically similar to deep fibromatoses (desmoid tumors).
- Trial name
- NCT03627741
- Testing
- Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Adults
Safety and Efficacy of Klotho and Follistatin Gene Therapy
The purpose of this study is to investigate the safety and efficacy of a combination klotho and follistatin gene therapy, delivered via a nonviral plasmid in healthy adult volunteers.
- Trial name
- NCT07285629
- Testing
- Follistatin and klotho gene therapy
- Where
- 2 sites in United States, Honduras
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Minicircle
Gastric Cancer, Non-small Cell Lung Cancer
Clinical Study to Compare the Pharmacokinetics and Safety of Ramucirumab Injection With Cyramza ® in Healthy Male Volunteers
Ramucirumab is a biosimilar drug of CYRAMZA® produced by Chiatai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., LTD. It is a vascular endothelial growth factor receptor 2 (VEGFR-2) antagonist.
- Conditions
- Gastric Cancer, Non-small Cell Lung Cancer, Colo-rectal Cancer
- Trial name
- NCT05800418
- Testing
- Ramucirumab Injection, Ramucirumab Injection [Cyramza]
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Healthy Volunteers
To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SIM0278 in Chinese Healthy Subjects
This is a Phase 1, randomized, double-blind, placebo-controlled trial of SIM0278 in healthy subjects. The study will be conducted in 2 parts. Part 1 is single ascending dose study. Part 2 is multiple ascending dose study.
- Trial name
- NCT06022354
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Pain
Safety, Tolerability and Pharmacokinetics of Meloxicam Nanocrystal Injection in Healthy Subjects
Primary Objective：To compare the pharmacokinetic profiles between meloxicam nanocrystal injection (strength: 1 mL: 30 mg, Yangtze River Pharmaceutical Group Co., Ltd.) and the originator meloxicam nanocrystal injection (trade…
- Trial name
- NCT06902090
- Testing
- Meloxicam Nanocrystal Injection(Yangtze River Pharmaceutical Group Co., Ltd.), Meloxicam Nanocrystal Injection (ANJESO®)
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yangtze River Pharmaceutical Group Co., Ltd.
Carpal Tunnel Syndrome
The Effect of Perineural Injection Therapy Versus Steroid in Patients With Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel.
- Trial name
- NCT02990962
- Testing
- 5% dextrose, 1cc 2% Xylocaine+4cc Triamcinolone (40mg)
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Asthma, Healthy Subjects or Volunteers
A Study of Tralokinumab When Delivered Subcutaneously at Different Flow Rates to Healthy Volunteers
The primary objective of this study is to evaluate the pharmacokinetics (PK) and tolerability of tralokinumab when delivered subcutaneously at different flow rates to healthy volunteers.
- Trial name
- NCT02085473
- Testing
- Tralokinumab 300 mg
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Labour Analgesia
Role of the Single-shot Spinal Analgesia to Control Labour Pain
Labor pain is the most severe pain most women will endure in their lifetimes. The most complete and effective method of pain relief during childbirth is neuraxial labor analgesia which provides adequate analgesia without maternal…
- Trial name
- NCT02800694
- Testing
- "bupivacainediluted with 1 ml of normal saline" and "25 μg fentanyl "
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Minia University
Covid19, Prophylaxis
Mesenchymal Stem Cells for the Treatment of COVID-19
This double blind, placebo controlled, multi-arm, multi-site study investigates the safety and efficacy of stem cell therapy for the treatment of patients admitted to hospital suffering complications from COVID-19 and the…
- Trial name
- NCT04573270
- Testing
- PrimePro
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
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