Clinical trials: Injections
Healthy Volunteers
Comparative Safety, Tolerability, Pharmacokinetic Study of AVT02 (100MG/ML) and Humira (100MG/ML) in Healthy Volunteers
Adalimumab is an immunosuppressive drug that belongs to the family of anti-TNF agents. It contains a monoclonal antibody produced by biotechnology.
- Trial name
- ALVOPAD (NCT03579823)
- Testing
- Adalimumab 100 MG/ML [Humira], AVT02 100MG/ML
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Alvotech Swiss AG
Healthy
Phase Ia Dose-Escalation Safety, Pharmacodynamic and Pharmacokinetic Study of Imprime PGG™ Injection
The purpose of this trial is to the assess the safety, pharmacodynamics, and pharmacokinetics of escalating doses of Imprime PGG™ Injection in healthy volunteers.
- Trial name
- NCT00542217
- Testing
- Imprime PGG
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- HiberCell, Inc.
Intramuscular Injection
Effect of Manual Pressure and Shotblocker on Pain and Injection Satisfaction in Intramuscular Injection Application
This study was planned as a single blind randomized controlled experimental study to investigate the effect of manual pressure applied before injection and ShotBlocker's pain and injection satisfaction due to intramuscular…
- Trial name
- NCT04883723
- Testing
- Shotblocker, Manual Pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Musculoskeletal Pain
Study to Evaluate EB-001 in Reducing Musculoskeletal Pain
To determine the safety and efficacy of single intra-operative treatment of EB-001 IM injections into the Pectoralis Major (PM) in subjects undergoing breast augmentation with subpectoral implants
- Trial name
- NCT03193593
- Testing
- EB-001
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bonti, Inc.
Primary Gonarthrosis
The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis
Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying…
- Trial name
- NCT05806021
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pain, Postoperative, Morbid Obesity
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
The purpose of this study is to determine if pre-incisional lidocaine injection, instilled liquid bupivacaine, intra-abdominal aerosolized bupivacaine, or post-operative bupivacaine injection is superior in post-operative pain…
- Trial name
- NCT00508976
- Testing
- Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pinnacle Health System
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Infertility
Intrauterine Injection of Human Chorionic Gonadotropin Injection (hCG) Before Embryo Transfer on Pregnancy Outcomes in Frozen Embryo Transfer Cycles.
The present study is designed as a pilot study with 50 patients in each group. Data collection form will be filled by the researcher who does not know the type of intervention in each group
- Trial name
- NCT02825108
- Testing
- Intra uterine injection of tissue culture medium containing HCG+ET, Intra uterine injection of tissue culture medium +ET, ET
- Where
- Iran
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Schizophrenia
Long-acting Paliperidone Palmitate Injection and Olanzapine for Schizophrenia
A randomized trial of olanzapine and Long-acting paliperidone palmitate injection in the treatment of 100 treatment- naive first-episode patients with schizophrenia.
- Trial name
- NCT02918825
- Testing
- Olanzapine, Paliperidone
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital
Aesthetic
Kiss and Smile HIT (Holistic Individualized Treatment)
The "Holistic Individualized Treatment" (HIT) approach is used to identify treatment priorities, focus areas, and appropriate products for soft tissue filler treatments.
- Trial name
- NCT06336785
- Testing
- Restylane line of soft tissue fillers and Dysport neuromodulator
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Healthy
Phase I Study of Kukoamine B Mesilate in Healthy Volunteers
The purpose of this study is to assess safety, tolerance and pharmacokinetics of a single intravenous injection Kukoamine B Mesilate in health volunteer
- Trial name
- NCT02219971
- Testing
- Kukoamine B Mesilate
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tianjin Chasesun Pharmaceutical Co., LTD
Migraine Disorders
An Open-label, Randomized, 3-period Crossover Study to Evaluate Sumatriptan Pharmacokinetics for a TREXIMA™ (Sumatriptan Succinate / Naproxen Sodium) Tablet Followed by IMITREX® (Sumatriptan Succinate)
This study will evaluate the exposure of sumatriptan after administration of TREXIMA (sumatriptan 85mg/naproxen sodium 500mg) followed by a subcutaneous IMITREX injection (4mg or 6mg) 2 hours later compared to administration of a…
- Trial name
- NCT00875784
- Testing
- TREXIMA™, IMITREX® (4mg), IMITREX® (6mg)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Overactive Bladder, Overactive Bladder Syndrome
Prophylactic Antibiotic Administration for Bladder OnabotulinumtoxinA Injection
The goal of this clinical trial is to evaluate the outcomes of differing durations of antibiotic prophylaxis with bladder onabotulinumtoxinA injection in patients with refractory overactive bladder.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Urge Incontinence, Urinary Incontinence, Urge
- Trial name
- NCT05719285
- Testing
- Single-Dose Antibiotic, Multi-Dose Antibiotic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Colles' Fracture
Weekly Use of Teriparatide to Accelerate Healing of Distal Radius Fracture
The purpose of this study is to examine the effect of weekly dosing strategy on fracture healing.
- Trial name
- NCT04473989
- Testing
- recombinant teriparatide for injection
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Contraception
Lower Dose Depo Provera® Contraceptive Injection
This is a randomized, partially-blinded, multi-center, parallel-group study to evaluate and compare the PD and PK of MPA after a single SC injection of either 45 mg/0.3 mL, 75 mg/0.5 mL or 105 mg/0.7 mL of Depo-Provera CI, and…
- Trial name
- NCT02732418
- Testing
- Depo-Provera CI, Depo-subQ 104
- Where
- 3 sites in Brazil, Chile and 1 more
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- FHI 360
Osteoarthritis
Comparison Between Four Types of Single Dose Hyaluronic Acid Injection in Patients With Knee Osteoarthritis
Study design: Allocation: Randomized. Endpoint Classification: Comparative Study. Intervention model: Parallel Assignment. Masking: Double Blind (Subject, Assessed) Primary purpose: Comparison.
- Trial name
- NCT01998308
- Testing
- Crespine gel, Intragel, Crespine plus gel
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- October 6 University
Healthy Participants
Comparative Pharmacokinetics of SHR-8068 and Ipilimumab in Healthy Chinese Men
This phase 1 study compared the pharmacokinetics of a single intravenous dose of SHR-8068 injection with ipilimumab (YERVOY®) in healthy Chinese men. Safety and immunogenicity were also evaluated.
- Trial name
- NCT07852325
- Testing
- SHR-8068, Ipilimumab
- Where
- China
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Arthroscope
Evaluation Study of Retro Discal Tissue Injection Arthroscopically Versus Ultrasound Guide Injection
A comparative evaluation study of arthroscopic retrodiscal tissue injection versus ultrasound-guided injection in temporomandibular joint disorders aims to assess differences in pain relief, functional improvement, and clinical…
- Trial name
- NCT07316790
- Testing
- Arthroscopic retrodiscal tissue injection, Ultrasound-guided retrodiscal tissue injection
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM)
Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers
This study is a randomized, double-blind, placebo-controlled, single-dose and multiple-dose, dose-escalation phase I clinical trial, aiming to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic…
- Conditions
- Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis
- Trial name
- NCT07801313
- Testing
- MWN105
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Coronavirus Disease (COVID-19)
Long-Term Follow-up Survey of COVID-19 Vaccine After Vaccination
This study is a long-term follow-up survey of Japanese people after their second vaccination with the Moderna COVID-19 vaccine. The study sponsor will not be involved in how the participants are treated but will provide…
- Trial name
- NCT04941144
- Testing
- COVID-19 Vaccine
- Where
- Japan
- Volunteers
- 8,538 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.