Clinical trials: Injections
Diabetes Mellitus, Type 2
A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People
In this study, participants will receive semaglutide and NNC0480-0389 together at the same time. Semaglutide is a medicine that can already be prescribed, whereas NNC0480-0389 is a new potential medicine.
- Trial name
- NCT05046873
- Testing
- Co-formulation NNC0480 0389+Semaglutide A 10/1 mg/mL, Semaglutide 1.34 mg/mL, NNC0480-0389 A 10 mg/mL
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Perianal Fistula
Perianal Fistula Treatment With Autologous Adipose Tissue Injection
The study aims to evaluate the efficacy of the local injection of autologous micro-fragmented adipose tissue obtained with the Lipogems®system in patients with trans-sphincteric fistulas untreatable with fistulotomy.
- Trial name
- NCT03913910
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Trismus, Edema
Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard Care
The surgical removal of impacted lower wisdom teeth (mandibular third molars) frequently leads to uncomfortable postoperative symptoms, including pain, facial swelling (edema), and restricted jaw movement (trismus).
- Conditions
- Trismus, Edema, Pain
- Trial name
- NCT07719270
- Testing
- Triamcinolone Acetonide 10mg, Kinesiology Taping, Standard Postoperative Care
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Allama Iqbal Medical College
Quality of Life, Injection Site Reaction
Simultaneous mRNA COVID-19 and IIV4 Vaccination Study
This study is a prospective, randomized clinical trial. During this study, participants will be randomly assigned to receive quadrivalent inactivated influenza vaccine (IIV4) and mRNA COVID-19 vaccine either simultaneously or…
- Conditions
- Quality of Life, Injection Site Reaction, Adverse Drug Event, Systemic Reaction
- Trial name
- NCT05028361
- Testing
- mRNA COVID-19, IIV4
- Where
- 3 sites in United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Duke University
Tennis Elbow, Epicondylitis, Lateral Humeral
A Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis
Lateral epicondylitis, is a common problem encountered in the orthopaedic practice. Histopathological reports have shown that lateral epicondylitis is not an inflammatory process but a degenerative condition termed 'tendinosis'.
- Trial name
- NCT00947765
- Testing
- Autologous blood injection, Local corticosteroid injection
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dojode, Chetan M., MBBS, MS
Uveal Melanoma
Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma
This phase II trial studies how well stereotactic body radiation therapy and aflibercept work in treating patients with uveal melanoma.
- Trial name
- NCT03712904
- Testing
- Stereotactic Body Radiation Therapy, Ziv-Aflibercept
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Age-Related Macular Degeneration
Study Of Combined VISUDYNE Therapy With Kenalog In CNV Secondary To Age-Related Macular Degeneration
To determine whether VISUDYNE therapy in combination with 4 mg intravitreal triamcinolone will reduce the average loss from baseline of best corrected visual acuity (BCVA) as compared with Visudyne therapy without intravitreal…
- Trial name
- NCT00140803
- Testing
- Visudyne, Kenalog
- Where
- 2 sites in United States, Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
Preventive Immunization COVID-19
An Open Study of the Safety, Tolerability and Immunogenicity of the Drug "Gam-COVID-Vac" Vaccine Against COVID-19
The purpose of the study is to assess safety, tolerability and immunogenicity of the drug "Gam-COVID-Vac ", a solution for intramuscular administration, with the participation of healthy volunteers Study objectives A safety and…
- Trial name
- NCT04436471
- Testing
- Gam-COVID-Vac
- Where
- Russia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Heterozygous Familial Hypercholesterolemia (HeFH)
A Study to Evaluate the SYH2053 Injection in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)
Heterozygous Familial Hypercholesterolemia (HeFH) is an autosomal dominant disorder characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C) and increased risk of atherosclerotic cardiovascular disease…
- Trial name
- NCT07465263
- Testing
- SYH2053 Injection
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.
Filovirus Infections, Ebola Virus Infection
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of BCX4430
This is a 2-part, first-in-human dose-ranging study to evaluate the safety, tolerability and pharmacokinetics of escalating doses of BCX4430 administered via intramuscular (IM) injection in healthy subjects.
- Trial name
- NCT02319772
- Testing
- BCX4430
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
HIV Pre-exposure Prophylaxis
Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)
The goal of this clinical study is to learn more about the study drug lenacapavir (LEN), safety, tolerability, and pharmacokinetics (how LEN is absorbed, modified, distributed, and removed from the body of the participants) of…
- Trial name
- PURPOSE 365 (NCT07047716)
- Testing
- Lenacapavir Injection, Lenacapavir Tablet
- Where
- 31 sites in United States
- Volunteers
- 339 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Nursing Care
The Effect of Nurse Training on the Improvement of Subcutaneous Heparin Applications
One of the most important duties and responsibilities of nurses is drug administration. During drug administration, the nurse uses appropriate administration techniques and ensures patient safety by knowing the drugs and their…
- Trial name
- NCT05469035
- Testing
- Mobile-based video, Face-to-face
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Knee Injuries
Femoral/Sciatic Block for Knee Surgery
Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.
- Trial name
- NCT02882152
- Testing
- femoral nerve blockade, morphine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Varicella Zoster Virus Infection
An Open-label, Bridging Study of BARYCELA Inj. in Healthy Vietnamese Children Aged Between 12 Months to 12 Years
The goal of this bridging study is to assess the safety and immunogenicity of BARYCELA inj. in healthy Vietnamese children aged between 12 months to 12 years. The main questions it aims to answer are: Safety of BARYCELA inj.
- Trial name
- NCT05664152
- Testing
- MG1111
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- GC Biopharma Corp
Pain, Acute Pain
Pain Induced by m-Cresol as Preservative
Preservatives such as m-Cresol are essential components in many subcutaneously injected medications, including insulin or human growth hormone, to prevent bacterial growth.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07600814
- Testing
- m-Cresol 0.1%, m-Cresol 0.25%, Control Solution
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pulpitis
Use of Tramadol Intraligamentary Injections
Introduction: To achieve painless treatment in patients with a failed primary IANB, supplementary anaesthesia has been advised. The majority of the studies evaluating intraligamentary injections have been performed on…
- Trial name
- NCT05538052
- Testing
- Tramadol hydrochloride, Lidocaine Hydrochloride
- Where
- India
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
Patients with Jaw Muscles Myofascial Pain
A Comparative Study on the Impact of Trigger Points Injection of Platelet Rich Plasma Versus Botulinum Toxin on the Relief of Jaw Muscles Myofascial Pain
This study aims at comparing the effect of trigger points injection of platelet rich plasma and botulinum toxin a on the relief of jaw muscles Myofascial pain .
- Trial name
- NCT06814535
- Testing
- Botulinum Toxin A / Botulinum Toxin A, Platelet rich plasma
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Psoriasis
Comparative Study to Evaluate the Pharmacokinetics of BAT2206 vs Stelara® in Healthy Subjects
It is a randomized, double-blinded, single-dose, 3-arm parallel, comparative study to evaluate the pharmacokinetics, safety and immunogenicity of BAT2206 Injection vs Stelara® (EU-licensed and US-licensed) in healthy Chinese male…
- Trial name
- NCT04371185
- Testing
- BAT2206, Stelara(US-licensed), Stelara(EU-licensed)
- Where
- China
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Bio-Thera Solutions
Safety
Single and Multiple Dose Escalation Trial of an Intravenous Antibiotic RC-01
A Phase 1 study of the safety, tolerability and pharmacokinetics of a new antibiotic (RC-01). In Part 1 cohorts of healthy adults will participate in a single dose escalation study of increasing intravenous doses of RC-01.
- Trial name
- NCT03832517
- Testing
- Single intravenous doses of RC-01, Multiple intravenous doses of RC-01
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Recida Therapeutics, Inc.
Single Ascending Dose, Healthy Subjects
A Study to Evaluate the Safety of GR2301 Injection in Healthy Volunteers.
This is a randomized, double-blind, placebo-controlled Phase I clinical trial evaluating the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary pharmacodynamic characteristics of GR2301 injection in healthy…
- Trial name
- NCT07190716
- Testing
- GR2301 injection
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
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