Clinical trials: Injections
Dental Caries
Clinical Performance of Bioactive Highly Filled Injectable Flowable Composite for Direct Posterior Occlusal Conservative Restorations Using FDI Criteria: Two Year Randomized Clinical Trial
The aim of this study is to evaluate Clinical Performance of bioactive highly filled injectable flowable composite for direct posterior occlusal conservative restorations using FDI Criteria
- Trial name
- NCT06790511
- Testing
- bioactive highly filled injectable flowable composite, highly filled injectable flowable composite
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neovascular Age-Related Macular Degeneration
A Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Injections in Participants With Wet Age-Related Macular Degeneration
Study GR40548 is a Phase III, randomized, multicenter, open-label (visual assessor [VA]-masked), active-comparator study designed to assess the efficacy, safety, and pharmacokinetics (PK) of 100mg/ml delivered via the Port…
- Trial name
- Archway (NCT03677934)
- Testing
- PDS Implant filled with 100 mg/mL Ranibizumab, Intravitreal Injections of 10 mg/mL Ranibizumab
- Where
- 77 sites in United States
- Volunteers
- 415 people
- Sponsor
- Hoffmann-La Roche
Plane Wart
Comparison Between Intralesional Injection of Plasma Rich Platelets and Candida Antigen in Plane Warts
To compare the efficacy of intralesional injection of autologous plasma rich platelets and candida antigen in treatment of patients with plane warts .
- Trial name
- NCT05652998
- Testing
- C. albicans antigen, autologous PRP, saline
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- South Valley University
Neuropathic Pain From Lumbosacral Radiculopathy
Single Ascending Doses Study of KLS-2031 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
Escalating single-dose design study to determine the safety, tolerability, and analgesic activity of KLS-2031
- Trial name
- NCT04238793
- Testing
- KLS-2031
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kolon Life Science
Asthma Severe Persistent Controlled
Phase I Clinical Trial of TQC2731 Injection
This is the first-in-human phase 1 trial of TQC2731 injection in healthy subjects and in patients with severe asthma to evaluate the safety, tolerability, pharmacokinetic characteristics and immunogenicity.
- Trial name
- NCT04923607
- Testing
- TQC2731
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Graft Shrinkage, Gingival Recession, Localized
Effect of i-PRF and LLLT on Free Gingival Graft Shrinkage
This randomized clinical trial aims to evaluate whether injectable platelet-rich fibrin (i-PRF) and low-level laser therapy (LLLT) can reduce graft shrinkage after free gingival graft procedures.
- Trial name
- NCT07303192
- Testing
- Free Gingival Graft (FGG), Injectable Platelet-Rich Fibrin (i-PRF), Low-Level Laser Therapy (LLLT)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Diabetic Nephropathies
Use of Wharton Jelly in Diabetic Nephropathy
Wharton Jelly derived Mesenchymal stem cells will be injected in the renal parenchyma of patients with Diabetic Nephropathy
- Trial name
- NCT03288571
- Testing
- Wharton Jelly Mesenchymal stem cells
- Volunteers
- 20 people
- Sponsor
- Sophia Al-Adwan
Hemophilia A With Inhibitor, Hemophilia B With Inhibitor
Efficacy and Safety of KN057 Prophylaxis in Patients With Haemophilia A or B With Inhibitors
The purpose of this study is to show that KN057 can prevent bleeds in patients with haemophilia A or B with inhibitors and is safe to use.
- Trial name
- NCT06312475
- Testing
- KN057
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Suzhou Alphamab Co., Ltd.
Complicated Urinary Tract Infections(cUTI)
Evaluation of the Safety, Tolerability and Pharmacokinetics of TUL108 for Injection in Healthy Participants (SAD/ MAD)
To evaluate the safety, tolerability and pharmacokinetics of single and multiple intravenous (IV) infusion of TUL108 in healthy participants.
- Trial name
- NCT07719257
- Testing
- TUL108
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Zhuhai United Laboratories Co., Ltd.
Caffeine, Flavonoids
Effects of a Cocoa Shot on the Human Brain
The Hershey Company is interested in investigating the effects of various chocolate beverages on brain physiology and cognitive function.
- Trial name
- NCT01924481
- Testing
- High Caffeine, Low caffeine, High theobromine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Diabetic Macular Edema
Intravitreal Injections of Ranibizumab With Deferred Laser Grid Laser Photocoagulation for Treatment of Diabetic Macular Edema With Visual Impairment
In the prospective monocentric open label trial patients with diabetic macular edema will be treated with intravitreal injections of ranibizumab given for 3 months then with laser grid at month 4.
- Trial name
- NCT01823965
- Testing
- ranibizumab
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Poitiers University Hospital
Intravitreal Injections
Eye Diseases "Treated" With Interoperable Medical Informatics
The overarching goal of EyeMatics is to promote an interoperable, sustainable infrastructure for the integration and sharing of data from clinical research to improve personalized medicine in ophthalmology.
- Trial name
- EyeMatics (NCT06810011)
- Where
- 6 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Muenster
Anal Fistula
Treatment of Perianal Fistulas by Endorectal Advancement Flap Associated With Adipose Tissue Injection
The study aims to evaluate effectiveness of the association of endorectal advancement flap technique with local injection of autologous and micro-fragmented adipose tissue, obtained with the Lipogems® system, in patients with…
- Trial name
- Fistula_CM1 (NCT04750499)
- Testing
- Adipose tissue injection associated with endorectal advancement flap.
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospital Clinic of Barcelona
Pain, Intravenous Propofol Injection
Effect of Dexmedetomidine on Pain Due to Propofol Injection
Propofol is commonly used IV anesthetic, it has been formulated in a concentration of 10 mg/ml in a fat emulsion consisting of 10% soybean oil (long-chain triglycerides).
- Trial name
- NCT01463332
- Testing
- I.V injection of 10 ml normal saline, I.V injection with 0.25mic/kg of dexmedetomidine, I.V injection of 0.50mic/kg of dexmedetomidine
- Volunteers
- 150 people
- Sponsor
- KVG Medical College and Hospital
Retinal Vein Occlusion, Macular Edema, Cystoid
Steroid Injections vs. Standard Treatment for Macular Edema Due to Retinal Blood Vessel Blockage
This study will compare the safety and effectiveness of two treatments-injections of triamcinolone acetonide into the eye vs. standard laser therapy-for macular edema (swelling in the center of the retina) that is caused by…
- Conditions
- Retinal Vein Occlusion, Macular Edema, Cystoid, Macular Edema
- Trial name
- NCT00106132
- Testing
- Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 1,260 people
- Sponsor
- National Eye Institute (NEI)
Infertile Patient Undergoing ICSI Procedure
Late-Start Corifollitropin Alfa in Mild Ovarian Stimulation
This prospective randomized clinical study evaluates a novel physiology-oriented mild ovarian stimulation protocol based on the delayed initiation of corifollitropin alfa.
- Trial name
- two injection (NCT07891793)
- Testing
- Corifollitropin Alfa 150 μg, GnRH antagonist, Progesterone
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- Assisting Nature
Gonarthrosis; Primary
The Effect of Different Intra-articular Injections Primary Gonarthrosis
Gonarthrosis is a frequent cause of knee pain and mostly related to altered function of the knee. Intra-articular injections are a valuable noninvasive medical treatment of choice for pain management and functional enhancement.
- Trial name
- NCT05291793
- Testing
- Tenoxicam 20 Mg Powder for Solution for Injection Vial, Methylprednisolone, Saline
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Nevsehir Haci Bektas Veli University
Obesity
Outcome of Gastric Fundus and Pylorus Botulinum Toxin A Injection
Newly, botulinum toxin A application into the stomach has been proposed as a treatment method in obesity. It impacts through acetylcholine receptors located in smooth muscle cells and suppresses stomach motility.
- Trial name
- NCT04948177
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Okan University
Pharmacokinetic Differences, Y-3
Y-3 for Injection in Patients With Hepatic Insufficiency and Healthy Subjects
The goal of this clinical trial is to assess the pharmacokinetic profiles and safety of Y-3 in subjects with mild hepatic insufficiency (Child-Pugh: grade A), moderate hepatic insufficiency (Child-Pugh: grade B) and gender, age…
- Conditions
- Pharmacokinetic Differences, Y-3, Saftey, Mild Hepatic Insufficiency
- Trial name
- NCT07055412
- Testing
- Y-3 for injection（40mg）
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Congestive Heart Failure, Coronary Artery Disease
Autologous Cultured Myoblasts (BioWhittaker) Transplanted Via Myocardial Injection
MyoCell™ implantation by epicardial injection during CABG surgery has the potential to add a new dimension to the management of post-infarct deterioration of cardiac function.
- Conditions
- Congestive Heart Failure, Coronary Artery Disease, Myocardial Infarction
- Trial name
- NCT00050765
- Testing
- MyoCell™ Autologous Myoblasts
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Bioheart, Inc.
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