Clinical trials: Inner Ear Disease
Noise, Vestibular Disorder
Development of Bone-vestibular Evoked Myogenic Potential
This study aims to evaluate the effects of different masking conditions on cervical vestibular evoked myogenic potential (cVEMP) responses.
- Trial name
- NCT06711653
- Testing
- Vestibular evoke myogenic potential
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Taipei City Hospital
Inner Ear ; Meniere's Disease; Imaging
Acceleration of the Kinetics of Diffusion of Gadolinium in the Perilymphatic Structures of the Inner Ear.
To determine the optimal delay after Gadolinium injection to analysis inner ear structures as measured by repeated MR 3D-FLAIR Weighted Imaging.
- Trial name
- FAST-HYDROPS (NCT04949321)
- Testing
- Magnetic Resonance Imaging with Single dose of gadobutrol (Gd-DO3A-butrol, Gadovist® 0.1 mmol/kg, 1 mmol/mL)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Hearing Loss, Dizziness
Fall Risk Assessment and Speech Intelligibility Enhancement Using In-ear Device
The purpose of this study is to develop and validate methods to use hearing aids equipped with embedded sensors and artificial intelligence to assist in the assessment of fall risk and in the implementation of interventions aimed…
- Conditions
- Hearing Loss, Dizziness, Vertigo, Fall Related Injury Risk
- Trial name
- NCT05365646
- Testing
- Hearing aids equipped with motion sensing abilities
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sensorineural Hearing Loss, Tinnitus
ACEMg Hearing Preservation, Tinnitus and Hyperacusis Relief
ACEMg (Soundbites) is a neuroprotectant supplement designed to block the initiating biological events in the inner ear leading to inner ear hearing loss, sensorineural hearing loss, SNHL, which accounts for more than 90% of all…
- Conditions
- Sensorineural Hearing Loss, Tinnitus, SNHL, Inner Ear Hearing Loss
- Trial name
- OTISRWD (NCT06477354)
- Testing
- ACEMg
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Keep Hearing, Inc.
Vestibular Function Disorder
Simultaneous Recordings of Cervical and Ocular Vestibular-evoked Myogenic Potentials
To lower the threshold for clinical application by reducing the testing time for recording vestibular-evoked myogenic potentials (VEMPs), we evaluated whether a simultaneous recording of ocular and cervical VEMPs after unilateral…
- Trial name
- NCT03049683
- Testing
- Vestibular evoked myogenic potentials (VEMPs)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vertigo
Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo
The goal of this clinical trial is to assess the efficacy and safety of a combination of aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine and cyanocobalamin as adjuvant therapy for vertigo comparatively to ginger…
- Trial name
- NCT05221892
- Testing
- Gamma-aminobutyric acid tartarate, glutamic acid, dibasic calcium phosphate, thiamine nitrate, pyridoxine chloride and cyanocobalamin, Ginger
- Where
- Brazil
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Fundação Educacional Serra dos Órgãos
Vestibular Disease
Human Visual and Vestibular Motion Perception Study
The purpose this study is to measure sensitivity to visual and vestibular or balance motion. It is hoped that the results may help researchers better understand how aging and disease affect motion perception.
- Trial name
- NCT04142697
- Testing
- Heading direction adaptation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Inner Ear Diseases
A Single Dose PK Study of SENS-218 in Healthy Volunteers
This study is to aid the development for the use of SENS-218 outside its marketed therapeutic indications. SENS-218 is available in Asia and is marketed as an anti-emetic (Anti-sickness) drug often prescribed after exposure to…
- Trial name
- NCT02772796
- Testing
- SENS-218
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Simbec Research
Laryngomalacia, Sleep Apnea, Obstructive
Laryngomalacia, Examinations and Quality of Life in Children Before and After Treatment With Follow-up After 1 Year
Laryngomalacia is the most frequent cause of stridor in children under 1 year. The airway obstruction generates turbulent airway flow and creates the characteristic high-frequency stridor sound.
- Conditions
- Laryngomalacia, Sleep Apnea, Obstructive, Sleep Apnea, Ear, Nose and Throat Disorder
- Trial name
- NCT06464757
- Where
- 2 sites in Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Benign Paroxysmal Positional Vertigo, Vertigo
The Cardiac Autonomic Control System Response to Vestibular Stimulation in Subjects With and Without BPPV
The vestibular system in the inner year is an important system in the body which is responsible for balance. In addition, there is evidence that the vestibular system plays a role in maintaining blood pressure while changing body…
- Conditions
- Benign Paroxysmal Positional Vertigo, Vertigo, Autonomic Nervous System
- Trial name
- NCT03867019
- Testing
- Heart rate variability parameters monitoring
- Where
- Israel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Meniere Disease, Psychosocial Problem
Comprehensive Evaluation in Patients With Meniere's Disease
The aim of our study is to determine the severity of the disease in people with Meniere's Disease; physical conditions such as balance, posture, pain, physical activity level, neck joint range of motion, proprioception; to…
- Conditions
- Meniere Disease, Psychosocial Problem, Physical Disability, Quality of Life
- Trial name
- NCT05844657
- Testing
- Case report form, Tinnitus disability scale, A feeling of fullness and/or pressure in the ear
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Benign Paroxysmal Positional Vertigo, Vitamin D
Evaluation of the Efficacy of Vertistop® D and Vertistop® L in the Prevention of BPPV Recurrence
The study involves the evaluation of 3 groups of subjects (3-arm study). Patients diagnosed with BPPV and "sufficient" serum concentrations of Vitamin D (>30 ng/mL, >75 nmol/L) at baseline may be treated with 2 tablets per day…
- Conditions
- Benign Paroxysmal Positional Vertigo, Vitamin D, Antioxidants
- Trial name
- NCT05748249
- Testing
- Vertistop® D
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vestibular System Disorder
The Effect of Galvanic Stimulation on vHIT and VEMP Tests
Introduction: Galvanic vestibular stimulation (GVS) is a well-established technique with a history spanning over a century, primarily used to manipulate the vestibular system.
- Trial name
- NCT06123949
- Testing
- Galvanic Vestibular Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Ménière's Disease
Pharmacokinetic Profile of Betahistine With and Without Selegiline in Healthy Volunteers
The goal of this pharmakokinetic trial is to demonstrate that Betahistine serum concentration is higher after combination treatment with Betahistine and Selegiline compared to Betahistine alone.
- Trial name
- PK-BesT (NCT05938517)
- Testing
- Betahistine dihydrochloride, Selegiline-hydrochloride
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Motion Sickness, Vertigo
Sensory Training for Orientation and Balance
This is a preliminary study of how human beings control balance and how symptoms of visually-induced dizziness may result in falls.
- Conditions
- Motion Sickness, Vertigo, Dizziness, Fall
- Trial name
- NCT04331561
- Testing
- sensory re-weighting
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
CNS Infection, Inner Ear Hearing Loss
CNS Infections Effect on the Inner Ear
Study on patients with CNS infections.
- Conditions
- CNS Infection, Inner Ear Hearing Loss, Vestibular Abnormality, Inner Ear Inflammation
- Trial name
- NCT03715569
- Testing
- Vestibular function, OAE/WBT, Biomarker
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Meniere's Disease, Enlarged Vestibular Aqueduct Syndrome
Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
Background: Disorders of hearing instability (HI) are poorly characterized and ineffectively treated. HI can cause fluctuations in hearing thresholds and speech understanding.
- Conditions
- Meniere's Disease, Enlarged Vestibular Aqueduct Syndrome, Autoimmune Inner Ear Disease
- Trial name
- NCT04806282
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Dizziness, Vertigo
The Relationship Between Dizziness and Neck Pain
Both dizziness and neck pain are common complaints in the Norwegian population. The cervical spine has a highly developed proprioceptive system, which is involved in head and gaze stabilization as well as postural control.
- Conditions
- Dizziness, Vertigo, Neck Pain
- Trial name
- NCT03531619
- Where
- Norway
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Vestibular Disease
Vibrotactile Feedback During Vestibular Therapy
This study evaluates the use of vibrotactile feedback to traditional vestibular treatment protocols. Half the patients will have vibrotactile feedback added to their treatment protocols while the other half will undergo…
- Trial name
- NCT02867683
- Testing
- Vibrotactile Feedback
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh