Clinical trials: Insufficiency, Pulmonary
Hypoxemic Respiratory Failure, Oxygen Toxicity
Handling Oxygenation Targets in COVID-19
Patients with COVID-19 and hypoxaemic respiratory failure and admitted to the intensive care unit (ICU) are treated with supplementary oxygen as a standard. However, quality of quantity evidence regarding this practise is low.
- Trial name
- HOT-COVID (NCT04425031)
- Testing
- Low oxygenation target, High oxygenation target
- Where
- 10 sites in Denmark, Norway and 1 more
- Volunteers
- 726 people
- Sponsor
- Aalborg University Hospital
Infant Respiratory Distress Syndrome, Respiratory Insufficiency
Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
The purpose of this study is to test whether application of high frequency ventilation through a nasal tube can lower blood carbon dioxide levels in stable preterm infants.
- Conditions
- Infant Respiratory Distress Syndrome, Respiratory Insufficiency, Apnea of Prematurity
- Trial name
- NCT00296231
- Testing
- Nasal high frequency ventilation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Tarah T Colaizy
Covid19, Chronic Kidney Diseases
Physical Activity Level in Patients with Chronic Kidney Disease During COVID-19 Pandemic
In the literature, there are no studies evaluating fear of COVID-19, anxiety, depression, physical activity, fear of movement and quality of life in patients with chronic kidney disease during COVID-19 pandemic.
- Trial name
- NCT04745923
- Where
- Turkey (Türkiye)
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pulmonary Embolism, Respiratory Failure
Construction of Early Warning Model for Pulmonary Complications Risk of Surgical Patients Based on Multimodal Data Fusion
The goal of this observational study is to establish an intelligent early warning system for acute and critical complications of the respiratory system such as pulmonary embolism and respiratory failure.
- Conditions
- Pulmonary Embolism, Respiratory Failure, Infection Complication, Cardiac Arrest
- Trial name
- NCT06057688
- Where
- China
- Volunteers
- 1,770 people, healthy volunteers welcome
- Sponsor
- Renrong Gong
COVID-19
Longitudinal Energy Expenditure and Metabolic Effects in Patients With COVID-19 (LEEP-COVID)
This current proposal evaluates the Longitudinal Energy Expenditure and Metabolic Effects in Patients with COVID-19 (LEEP-COVID) to understand, guide and optimize our metabolic and nutritional care of these high risk patients.
- Trial name
- NCT04350073
- Testing
- Q-NRG Metobolic Cart Device, MuscleSound Ultrasound, Multifrequency Bioimpedance Spectroscopy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Duke University
Diabetes Mellitus, Congestive Heart Failure
Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1
The goal of this observational study is to describe the impacts of COVID-19 on primary care chronic condition management in Canada within various patient populations.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease
- Trial name
- RIPPLE-C (NCT05813652)
- Testing
- Pre-pandemic time period (Jun 22, 2018 to March 12, 2020), Peri-pandemic time period (March 13, 2020 to December 3, 2021)
- Where
- Canada
- Volunteers
- 919,928 people
- Sponsor
- McMaster University
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (COVID-19) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Dyspnea
- Trial name
- NoCovid (NCT04290858)
- Testing
- Nitric Oxide
- Sponsor
- Xijing Hospital
ARDS, Covid19
Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome (ARDS)
Prone positioning is one of the few therapies known to improve mortality in ARDS. Traditionally, patients are proned for 16 hours per 24 hour period. Some retrospective data suggests improvement may persist beyond 16 hours.
- Conditions
- ARDS, Covid19, Acute Hypoxemic Respiratory Failure
- Trial name
- NCT04581811
- Testing
- Prolonged Proned Positioning, Traditional Proning Arm
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Alabama at Birmingham
COPD, Chronic Respiratory Disease
Three-min Step Test and Exercise Desaturation Detection in Chronic Respiratory Insufficiency Patients
The study project will aim at the evaluation of the occurrence of exercise desaturation phenomenon during two different modalities of exercise (walking and stepping condition).
- Trial name
- STEPSAT (NCT04911764)
- Testing
- Three-min Step Test and Exercise desaturation detection in COPD
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Limoges
Covid19, Nasopharyngitis
BNO 1030 Extract (Imupret) in the Treatment of Mild Forms of COVID-19
According to WHO (World Health Organisation) data, about 40% of patients with COVID-19 (Corona Virus SARS-CoV-2) have a mild course of the disease, namely, cases of mild course are of great danger from the point of view of the…
- Conditions
- Covid19, Nasopharyngitis, Anosmia, Fever
- Trial name
- NCT04797936
- Testing
- BNO 1030, Standard care
- Where
- Ukraine
- Volunteers
- 133 people
- Sponsor
- Ivano-Frankivsk National Medical University
Hypoventilation, Hypoxemia
Postoperative Respiratory and Activity Monitoring
This study plans to learn more about specific breathing and activity recommendations for patients after surgery. Participants will be monitored after abdominal surgery to identify what activities help them breathe better and…
- Conditions
- Hypoventilation, Hypoxemia, Postoperative Pulmonary Complications
- Trial name
- NCT06239831
- Testing
- ExSpiron and ActivPAL Monitors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Infection, Heart Failure
Hospital-Level Care at Home for Acutely Ill Adults
The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be…
- Conditions
- Infection, Heart Failure, COPD, Asthma
- Trial name
- NCT03203759
- Testing
- Home hospitalization, Traditional inpatient hospitalization
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Brigham and Women's Hospital
Congenital Heart Disease, Fallot Tetralogy
Prospective Evaluation of Programmed Ventricular Stimulation Before Pulmonary Valve Replacement in Patients With Tetralogy of Fallot
Severe pulmonary regurgitation is common in patients with Tetralogy of Fallot and results in progressive right ventricular dilatation and dysfunction.
- Conditions
- Congenital Heart Disease, Fallot Tetralogy, Ventricular Arrythmia, Pulmonary Valve Regurgitation
- Trial name
- NCT04205461
- Testing
- Programmed ventricular stimulation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Paris Cardiovascular Research Center (Inserm U970)
CKD (Chronic Kidney Disease) Stage 5D, Pneumonia
Duration of Protection From Pneumonia After Pneumococcal Vaccination in Hemodialysis Patients
The investigators compare two strata of vaccinated patients: those recently vaccinated and those vaccinated more than two years ago. The primary objective is to compare pneumonia rates between the groups.
- Trial name
- DOPPIO (NCT03350425)
- Where
- 12 sites in Germany
- Volunteers
- 792 people
- Sponsor
- University of Cologne
COPD, Chronic Respiratory Insufficiency
Oxygen Titration Protocol for Exertion of COPD Patients by an Automated Adjustment Device
The aim of our study is to assess if an automated titration of oxygen flow during exertion can be a useful tool to determinate the level of oxygen required by COPD patients that are using oxygen therapy during exercise.
- Trial name
- NCT04189991
- Testing
- Free 02
- Where
- France
- Volunteers
- 25 people
- Sponsor
- ADIR Association
Acute Respiratory Distress Syndrome, Pneumonia in Children
AI-Guided Mechanical Ventilation in Children: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to evaluate whether an AI-driven decision support system can improve clinical outcomes for mechanically ventilated pediatric patients (aged 1 month to 18 years) in the PICU…
- Conditions
- Acute Respiratory Distress Syndrome, Pneumonia in Children, Respiratory Failure (Pediatric Patients), Congenital Heart Disease in Children
- Trial name
- NCT07728136
- Testing
- AI-generated recommendations for ventilator parameters.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wu Rongzhou
COVID-19, Respiratory Failure
Compartmental Inflammation in Mechanically Ventilated Patients With COVID-19
The aim of the present study is to examine the inflammatory response in the pulmonary compartment and blood of critically ill patients admitted to the ICU with COVID-19.
- Trial name
- COV2ICU-DK (NCT04354584)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)
International Registry of Congenital Portosystemic Shunt (IRCPSS)
Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and severity of associated complications.
- Trial name
- IRCPSS (NCT06041906)
- Testing
- Shunt Closure
- Where
- 26 sites in United States, Australia and 14 more
- Volunteers
- 500 people
- Sponsor
- Prof. Valérie Mc Lin
Obesity, Morbid, Ventilator-Induced Lung Injury
Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon
This is a research study to determine if identifying an optimal level of positive end-expiratory pressure (PEEP) targeted specifically to individualized patient characteristics will shorten the time on the ventilator.
- Conditions
- Obesity, Morbid, Ventilator-Induced Lung Injury, Respiratory Failure
- Trial name
- PROP OPEN (NCT03951064)
- Testing
- Esophageal balloon, Intervention Spontaneous Breathing Trial (SBT) and Extubation, Control Spontaneous Breathing Trial and Extubation
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Mechanical Complication of Coronary Artery Bypass Graft, Respiratory Depression
Effects of Osteopathic Treatment on Pulmonary Function After Coronary Artery Bypass Graft Surgery
The purpose of this study is to determine the short and long term effects of osteopathic treatment on pulmonary function, pain and quality of life in patients after coronary artery bypass graft (CABG) surgery.
- Conditions
- Mechanical Complication of Coronary Artery Bypass Graft, Respiratory Depression, Pain, Quality of Life
- Trial name
- OSTinCARE (NCT01714791)
- Testing
- Usual care, Osteopathic treatment
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Hartcentrum Hasselt
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