Clinical trials: Insulin Homeostasis
GDM, Insulin Resistance
In Vitro Fertilization Impact on Metabolic Parameters
A quantitative prospective cohort study will be conducted, where blood samples will be collected at different timings during the IVF protocol, to assess the impact of fertility medications on metabolic parameters of patients…
- Conditions
- GDM, Insulin Resistance, Glucose Intolerance, PCOS
- Trial name
- IVF (NCT03426228)
- Testing
- HbA1C
- Where
- United Arab Emirates
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Pre Diabetes
Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity
The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.
- Trial name
- ABA (NCT04722354)
- Testing
- Hyperinsulemic euglycemic clamp, Muscle Biopsy, Oral abscisic acid (ABA)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Healthy, Metabolic Syndrome
Study of Metabolic Homeostasis in Chinese
In this open-label, acute intervention study, we will recruit 120 sex-matched participants aged 20-70 years (100 normal or overweight/obese subjects and 20 Mets subjects).
- Trial name
- NCT04173728
- Testing
- Standard mixed macronutrients tolerance test
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Obesity
Effect of Fibre Products on Appetite and Weight
This study explores the nutritional effects of fibre. Short chain fatty acid(SCFA), such as propionate, are produced through the fermentation of fibre in the bowel.
- Trial name
- NCT00750438
- Testing
- Propionate ester, Inulin, Cellulose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dysglycemia, Type 2 Diabetes Mellitus
Alkaline Diet for Insulin Sensitivity
The purpose of this study is to test the effect of increasing the body pH acutely with an alkaline medication (sodium bicarbonate, NaHCO3, sodibic) on glucose metabolism post meal in non diabetic subjects with normal renal…
- Trial name
- ADIS (NCT02501343)
- Testing
- Sodium Bicarbonate Oral Capsule
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Insulin Resistance, Type 2 Diabetes Mellitus with Features of Insulin Resistance
NUTRITIONAL INTERVENTION STUDY to EVALUATE the EFFECT of ACHETA DOMESTICUS POWDER CONSUMPTION on GLUCOSE HOMEOSTASIS and INTESTINAL DYSBIOSIS in HEALTHY and PREDIABETIC POPULATION.
A nutritional intervention study is proposed to evaluate the association between the consumption of A. domesticus (insect protein) powder and the effect on insulin resistance and the microbiome, in order to generate personalized…
- Trial name
- DIBAN (NCT06622616)
- Testing
- EVALUATE THE EFFECT OF ACHETA DOMESTICUS POWDER CONSUMPTION ON GLUCOSE HOMEOSTASIS AND INTESTINAL DYSBIOSIS
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- María Isabel Espinosa
Glucose Homeostasis
Comparison of the Effects of a 12-Week Consumption of Two Carbonated Beverages on Insulin Sensitivity
The purpose of this study is to determine whether consumption of carbonated drinks containing sweeteners affect insulin sensitivity.
- Trial name
- SEDULC (NCT02031497)
- Testing
- Drink with sweeteners, Drink without sweeteners
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute For European Expertise in Physiology
Healthy
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the…
- Trial name
- NCT02931643
- Testing
- High fat challenge breakfast, High fat challenge breakfast with mixed-spices
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity
Acylated Ghrelin Response to Acute Exercise in Obesity
Ghrelin is a GH-secretagogue gastrointestinal hormone that regulates feeding behavior by interacting directly with hypothalamic centers in concert with other negative and permissive neuromodulators.
- Trial name
- aeroghre (NCT00486161)
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose
Lactose, Sucrose & Corn Syrup Tolerance
Lactose, one of the key nutrients in human milk may be critically important to infants for more reasons than being a source of energy.
- Trial name
- NCT01789307
- Testing
- corn syrup solids, sucrose
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Morbid Obesity, Metabolic Syndrome
FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT
This double-blinded proof-of-concept study is proposed to explore the effects of fecal microbiota transfer (FMT) in human subjects.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes
- Trial name
- DACH (NCT06268990)
- Testing
- Fecal microbiota transplantation
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wiebke Kristin Fenske
Deficiency, Vitamin D, Insulin Resistance
Vitamin D Supplementation and and Glycemic Indexes
Age affect insulin sensitivity and the metabolism, and vitamin D status was shown to have a correlation with markers of insulin resistance.
- Trial name
- NCT03478475
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Université d'Auvergne
Type 1 Diabetes, Bariatric Surgery Candidate
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging
The primary objective of this study is to assess hepatic glucose uptake using non-invasive metabolic imaging in three different populations that differ in terms of insulin and glucose kinetics.
- Trial name
- LEMON (NCT04352738)
- Testing
- Multiparametric, multinuclear MR (DMI/ 13C-MRS/ GlycoCEST/GlycoNOE)
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Insulin Sensitivity, Oxidative Stress
Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study
Investigators will test the hypothesis that chronic restoration of vagal nerve activity with a central acetylcholinesterase inhibitor improves insulin sensitivity and reduces adipose tissue oxidation in obese African American…
- Trial name
- RDVCGH (NCT03014323)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Glucose Intolerance, Type 2 Diabetes Mellitus
Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes
The purpose of the randomized trial is to quantify the effect of vitamin D and calcium supplementation on beta-cell function, insulin sensitivity, glucose tolerance and systemic inflammation and other cardiometabolic outcomes in…
- Conditions
- Glucose Intolerance, Type 2 Diabetes Mellitus, Metabolic Syndrome
- Trial name
- CaDDM (NCT00436475)
- Testing
- Vitamin D3 2,000 IU orally once daily, Calcium Carbonate 400 mg orally twice daily
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Metabolic Syndrome X
Soy Protein Intake and the Metabolic Syndrome
Soy protein has a high biological value, and contains several potential health-related nutritional factors, i.e. its amino acids pattern, biological active peptides and non-protein compounds such as isoflavones.
- Trial name
- SOY (NCT01694056)
- Testing
- Soy protein diet, Control diet
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Polycystic Ovary Syndrome (PCOS), Betatrophin
Serum Betatrophin Levels in Normal-Weight and Overweight Adolescents With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in adolescents and women of reproductive age and is frequently associated with insulin resistance and an increased risk of metabolic complications.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Betatrophin, Body Mass Index (BMI), Insulin Resistance
- Trial name
- NCT07480993
- Testing
- Serum betatrophin levels
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Healthy
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
A body of epidemiologic studies show that moderate alcohol consumption is associated with a protective effect against type 2 diabetes.
- Trial name
- NCT00524550
- Testing
- moderate alcohol consumption
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Glucose Homeostasis
Postprandial Glucose Handing in Contraceptive and IUD Users
Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as…
- Trial name
- HCPG (NCT07169591)
- Testing
- Oral Glucose Tolerance test (75g 2-hour)
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Glucose Homeostasis
Effects of Oral GLP-1 on Glucose Homeostasis and Appetite Profile in Healthy Male Subjects
The investigators aimed to investigate the pharmacokinetic and pharmacodynamic effects of a single dose (2 mg) of oral GLP-1 administered prior to an oral glucose tolerance test (oGTT) in 16 healthy males
- Trial name
- NCT00822003
- Testing
- Oral GLP-1
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland