Clinical trials: Insulin Resistance, Diabetes
Gestational Diabetes, Pregnancy Related
Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes (START 2)
The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM).
- Trial name
- START2 (NCT06419803)
- Testing
- Insulin
- Where
- 2 sites in United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Diabetes
Nitrite Infusion in Islet Cell Transplantation
This study seeks to investigate the effects of administering nitrite to pancreatic islet cells that have been removed from a patient for autotransplantation.
- Trial name
- NCT03544242
- Testing
- Control, Pre-Isolation Infusion, Post-Isolation Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Metabolic Syndrome
Pomegranate Consumption by Poly-medicated Metabolic Syndrome Patients
The objective is to evaluate whether the medication in polymedicated metabolic syndrome patients could determine the effects of a pomegranate extract on i) metabolic markers, ii) inflammatory markers, and iii) the modulation of…
- Trial name
- NCT04075032
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Type2 Diabetes, Insulin Resistance
Does Time Restricted Feeding Improve Glycaemic Control in Overweight Men?
Obesity is a serious medical condition, the adverse consequences of which include increased risk of cardiovascular disease, diabetes mellitus, reduced fertility and cancer.
- Trial name
- RESHAPE2 (NCT03278236)
- Testing
- TRF
- Where
- Australia
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Diabetes Mellitus, Essential Hypertension
The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension
The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension.
- Trial name
- NCT01342614
- Testing
- Fosinopril, Metformin
- Volunteers
- 140 people
- Sponsor
- China-Japan Friendship Hospital
Cognitive Decline
Preventing Cognitive Decline with Metformin
A randomised control study of metformin in people with mild cognitive impairment and without diabetes mellitus to determine effects on cognitive decline and neuroimaging over 3 years.
- Trial name
- MetMemory (NCT04511416)
- Testing
- Metformin XR, 500-2000mg nocte
- Where
- Australia
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Type2 Diabetes Mellitus, Obesity
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation
Several free fatty acids receptors (FFARs) have been discovered. These have been implicated in metabolic processes and inflammation.
- Trial name
- NCT03062592
- Testing
- Pine nut oil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Diabetes Mellitus, Carbohydrates
SUCCEED - Soroka Utility for Counting Carbs Easily and Effectively for Diabetes
Counting Carbohydrates (CC) is the preferable method used to calculate the amount of insulin needed for a meal. This method is employed by patients with type 1 diabetes melitus (T1DM).
- Conditions
- Diabetes Mellitus, Carbohydrates, Insulin Sensitivity, HbA1C
- Trial name
- NCT04132128
- Testing
- carbohydrate counting
- Volunteers
- 107 people
- Sponsor
- Soroka University Medical Center
Sleep Apnea Syndromes, Metabolic Syndrome
Evaluating of the Impact of a Connected and Non-intrusive Device in Improving the Screening of Sleep Apnea Syndrome and the Addressing of Potentially Pathological Patients in Hospital Environment
Diabetes, obesity and metabolic syndrome are closely linked to sleep apnea syndrome. Indeed, diabetic and/or obese patients present an increased risk of sleep apnoea syndrome (SAS), with a prevalence estimated at between 10 and…
- Conditions
- Sleep Apnea Syndromes, Metabolic Syndrome, Diabetes, Obese
- Trial name
- AMELIAS (NCT06141967)
- Testing
- WITHINGS Sleep Analyzer
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Metabolic Syndrome, Pre-diabetes
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health
In a randomized controlled trial, the investigators intend to measure the health impact of time restricted eating (TRE) in patients with metabolic syndrome (with elevated blood pressure and at least 2 of the following: increased…
- Trial name
- TIMET 2 (NCT07189234)
- Testing
- Time-restricted eating (TRE) + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of California, San Diego
Type 1 Diabetes, Type 2 Diabetes
Safety Study of Using Symlin Alongside Insulin in a Multiple Injection Port
The purpose of this study is to determine whether injecting Symlin and insulin through a multiple injection port is safe and effective.
- Trial name
- NCT00790699
- Testing
- I-PORT, standard injections
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Texas Diabetes & Endocrinology, P.A.
Obesity, Insulin Resistance
Microbiome Insulin Sensitivity Study
The Microbiome Insulin Sensitivity Study "MISS" is a pilot study designed to study microbiome composition across puberty and how it relates to insulin sensitivity and secretion in obese girls, who are at increased risk for…
- Conditions
- Obesity, Insulin Resistance, Type2 Diabetes
- Trial name
- MISS (NCT03120871)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Metabolic Syndrome X, Diabetes Mellitus, Type 2
Efficacy of Topiramate for Weight Loss in Subjects With Metabolic Syndrome
The purpose of this study is to evaluate the efficacy of topiramate compared to placebo in the treatment of obesity in metabolic syndrome.
- Trial name
- NCT00243984
- Testing
- topiramate
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- Northeastern Ohio Universities College of Medicine
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 24 Hours in Adults and Adolescents With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01754337
- Testing
- Closed-loop system
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus, Type 1, Type 1 Diabetes
Feasibility of Closed-loop Automated Insulin Delivery System by Primary Care & Endocrinology, in Person & Via Telehealth
This is a study assessing the feasibility of using the insulin-only configuration of the iLet bionic pancreas with initiation in pump-naïve people with type 1 diabetes in a primary care practice with either in-person training and…
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Diabetes, Autoimmune, Diabetes type1
- Trial name
- NCT05168657
- Testing
- Bionic Pancreas, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Schizophrenia
A Placebo-Controlled, Cross-Over Trial of Aripiprazole
This study is a ten-week, placebo-controlled, double-blind, cross-over, randomized trial of the novel antipsychotic agent, aripiprazole, added to 20 obese stable olanzapine-treated patients with schizophrenia or schizoaffective…
- Trial name
- NCT00351936
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Insulin Resistance, Type 2 Diabetes
The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity
This study will investigate the effect of high-carbohydrate vs. high-fat overfeeding (130% of energy requirements) on whole body insulin sensitivity.
- Conditions
- Insulin Resistance, Type 2 Diabetes, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT03863431
- Testing
- High-fat diet, High-carbohydrate diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Adiposity, Metabolic Syndrome
Meta-analysis of Low-calorie Sweetened Beverages and Cardiometabolic Outcomes
We propose to conduct a systematic literature review and meta-analysis to assess the association of low-calorie sweetened beverages (LCSBs) on cardiometabolic outcomes in prospective cohort studies.
- Conditions
- Adiposity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Diseases
- Trial name
- NCT04245826
- Testing
- Change in LCSBs Intake, Substitute LCSBs for SSBs or Water
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes, PreDiabetes
Behavioral Economics for Activity Motivation in Adolescents (BEAM)
There is an urgent need to engineer targeted physical activity interventions that are effective and scalable for obese adolescents and young adults (AYA) with type 2 diabetes (T2D), who often have very low levels of physical…
- Conditions
- Type 2 Diabetes, PreDiabetes, Insulin Resistance, Polycystic Ovary Syndrome
- Trial name
- NCT04874415
- Testing
- 1RLD, 1RLW, 1RGD
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Pittsburgh
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of GP40071 Compared to NovoRapid® Penfill® in Type 1 Diabetes Mellitus Patients
This trial is a multi-center, open-label, randomized, parallel group trial in adult patients with T1DM comparing the efficacy and safety of GP40071 (insulin aspart, GEROPHARM) with that of NovoRapid®.
- Trial name
- NCT04079413
- Testing
- GP40071, NovoRapid® Penfill®
- Where
- 14 sites in Russia
- Volunteers
- 264 people
- Sponsor
- Geropharm
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