Clinical trials: Insulin Response
Pre-diabetes, Metabolic Syndrome
Replacing Refined Carbohydrates With Healthy Fats on Cardio-metabolic Markers
The primary goal is to to characterize the effects of consuming 1 avocado fruit 7 days / week (5-7 days is acceptable) compared to a no avocado relatively low fat, carbohydrate control treatment over a 12 week period on insulin…
- Trial name
- AV2 (NCT02695433)
- Testing
- Active, Control
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Overweight, Microbiota
Effects of Maple Syrup on Gut Microbiota Diversity and Metabolic Syndrome
It has been suggested that the actual obesity epidemy is related to chronic overconsumption of added or free sugars. The increasing popularity of artificial sweeteners attest the population willingness to reduce added sugars…
- Conditions
- Overweight, Microbiota, Endotoxemia, Metabolic Syndrome
- Trial name
- NCT04117802
- Testing
- Maple syrup
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Laval University
Hyperglycemia, Insulin Sensitivity
Glycemic and Hormone Responses After the Intake of Four Types of Bread.
The purposes of the present study are to determine the glycemic and insulinemic responses, the satiety rate and the postprandial plasma concentrations of free fatty acids, triglycerides and satiety hormones after the ingestion of…
- Trial name
- NCT02653677
- Testing
- intake of the specific kind of bread
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Glucose Response, Insulin Response
Glucose and Insulin Responses to Test Foods
In this study, postprandial glucose and insulin responses of different foods will be measured in individuals with varying body weight.
- Trial name
- NCT01671878
- Testing
- Reference Glucose, Test Food 1 (Cereal), Test Food 2 (Biscuit)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Insulin Sensitivity, Glucose Tolerance
Effect of Camel Milk on Insulin and Incretin Response
To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance
- Trial name
- NCT03725969
- Testing
- Camel milk, Cow milk
- Where
- United Arab Emirates
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Insulin Resistance, Obesity
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adolescents
The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adolescents using fMRI, psychophysical measures, and questionnaires.
- Trial name
- NCT02499705
- Testing
- Sucralose, Sucrose, Sucralose + maltodextrin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Post-prandial Glycaemia
Effect of Peas in Soup on Blood Glucose Control
This study is part of a group of studies whose overall goal is to accurately define the physiochemical and structural effects of pea varieties and relate these to blood glucose attenuation in healthy human volunteers.
- Trial name
- PEA4 (NCT03306862)
- Testing
- Whole yellow pea soup, Split yellow pea soup, Potato soup
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- St. Boniface Hospital
Metabolic Syndrome
Lipid and Glucose Response to Plant-based and Regular Burgers
This study evaluates the blood lipid and glucose response to two burgers: 1) A plant-based meat alternative burger and 2) a regular beef burger in a cross-over trial.
- Trial name
- NCT07766928
- Testing
- Acute consumption of different burger types
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Post-prandial Glycaemic Response
Effect of Pea Flour in Bread on Blood Glucose
This study's overall goal is to investigate methods to improve the acceptability of pulse containing foods that provide a health benefit to consumers.
- Trial name
- NCT03506932
- Testing
- Untreated, Heat treated with 0% moisture, Heat treated with 10% moisture
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- St. Boniface Hospital
Dietary Modification, Healthy
Acute Glycemic and Insulinemic Response of FOSSENCE™
Short chain fructooligosaccharide (FOS) is known as a prebiotic fiber/nutrient and has been documented to demonstrate different health benefits including glucose control, gut health, mineral absorption, weight and immunity.
- Trial name
- NCT03755232
- Testing
- scFOS, Control
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TATA CHEMICALS LTD
Diabetes Mellitus
Effects of Standardized Meals on the Metabolic, Hormonal and Inflammatory Responses in Human
Meal composition is important for blood sugar levels in patients with diabetes. The aim of this study is to investigate if a meal composition of fat, protein and carbohydrate is important for the hormonal and inflammatory…
- Trial name
- NCT02544568
- Testing
- Meals
- Where
- Sweden
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Insulin Sensitivity
Palmitoleic Isomer Study
Trans-palmitoleic acid (trans-C16:1) is a naturally occurring trans fatty acid present in small quantities in foods, most notably in dairy products.
- Trial name
- NCT02311790
- Testing
- Trans-C16:1 supplement, Cis-C16:1 supplement
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Tufts University
Glycemic Control, Diabetes Mellitus Risk
Effects of Seaweed Extract on Postprandial Response to White Bread
The study is designed to determine whether seaweed extract added to a carbohydrate-rich meal, can lower blood glucose levels after its consumption, and hence lower its glycaemic index, and if this effect is mediated through…
- Conditions
- Glycemic Control, Diabetes Mellitus Risk, Glucose Intolerance, Postprandial Hyperglycemia
- Trial name
- NCT05460884
- Testing
- Seaweed extract LD and white bread, Seaweed extract HD and white bread, White bread
- Where
- Ireland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Type 1 Diabetes, Insulin Sensitivity/Resistance
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
GLP-1 increases skeletal and cardiac microvascular perfusion and improves insulin's microvascular responses in human subjects with T1DM, leading to improved metabolic insulin responses, endothelial function, and increased muscle…
- Trial name
- KML001 (NCT04133922)
- Testing
- GLP-1, Insulin, Dextrose 20 % in Water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Postprandial Hyperglycemia
Postprandial Glucose, Insulin Response to Meal Sequence Among Healthy UAE Adults
the goal of this Randomized controlled cross over trial is to compare the effects of meal sequences VPF meal vs. SMM on the incremental area under the curve of postprandial glucose response among healthy adults in the UAE.
- Trial name
- NCT05878301
- Testing
- vegetable and protein first followed by carbohydrates (VPF) meal sequence
- Where
- United Arab Emirates
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Metabolic Disorder; Carbohydrate, Absorption, Intestine
Determination of the Postprandial Responses to Two Cereal Foods Differing by Their SDS Content Consumed Alone.
This study aimed at determining the 4-hours postprandial blood glucose and insulin responses to the ingestion of cereal product differing by their SDS content.
- Trial name
- NCT02538653
- Testing
- Sandwich biscuit high in SDS, Co-extruded cereal low in SDS
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Healthy, Hunger
Metabolic Response to Variations in Dietary Glycemic Index
The goal of this study is to compare metabolic response to variations in dietary glycemic index in healthy participants. The main questions it aims to answer are: What are the metabolic hunger and food intake responses to…
- Conditions
- Healthy, Hunger, Food Preferences
- Trial name
- NCT05804942
- Testing
- High glycemic index, Medium glycemic index, Low glycemic index
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Sepsis
Effect of Lipopolysaccharide on Skeletal Muscle Functions
The investigators aim to examine how the skeletal muscles of the human volunteers respond to experimental septic conditions to aid understanding of muscle wasting and its biology..
- Trial name
- LPS (NCT01423968)
- Testing
- Lipopolysaccharide infusion, saline
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Glucose Response
Palm And Rice Bran Oil Study
The objective of the present study is to compare the effects of liquid or solid state of food on glycaemia, lipaemia and insulinaemia.
- Trial name
- PARBO (NCT02969057)
- Testing
- Breakfast with rice bran oil gel, Breakfast with rice bran oil, Breakfast with palm oil gel
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Cardiovascular Disease
Effect of Fruit and Vegetables on Insulin Resistance
Current evidence indicates that fruit and vegetable intake and dietary patterns rich in fruit and vegetables may be associated with reduced insulin resistance and may reduce the risk of the metabolic syndrome.
- Trial name
- FIRST (NCT00874341)
- Testing
- Fruit and vegetable intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast