Clinical trials: Insulin Therapy
Infant, Small for Gestational Age
Safety Study In Patients Who Were Born Small And Short And Were Treated With Growth Hormone To Achieve Normal Height
The purpose of this study is to demonstrate that insulin sensitivity is not different between growth hormone - treated subjects who are small for gestational age (SGA) and an SGA cohort of subjects matched by gender and body mass…
- Trial name
- NCT00396474
- Testing
- post GH treatment observational study
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Overweight
Barriers to Effective Weight Loss in Overweight Adolescents
The current study aims to investigate the impact of a comprehensive, team-based, family-centered, lifestyle modification program on body weight, metabolic abnormalities, fitness measures, and self-esteem in overweight adolescents…
- Trial name
- TEENS (NCT00562263)
- Testing
- Lifestyle modification
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Gestational Diabetes, Hypoglycemia, Neonatal
Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial
Pregnant women with gestational diabetes who are treated with insulin and their daily insulin dose is 30 IU or more will be randomized into two groups. Active treatment group will receive insulin-glucose-infusion during labour.
- Trial name
- NCT02590016
- Testing
- Insulin, Aspart
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Hyperuricemia, Prediabetes
Effect of Allopurinol Treatment on Insulin Resistance
Several studies showed that hyperuricemia is an independent risk factor for development of diabetes mellitus. However none of the previous studies have investigated the effect of lowering serum uric acid levels on insulin…
- Conditions
- Hyperuricemia, Prediabetes, Insulin Resistance
- Trial name
- NCT02008968
- Testing
- allopurinol 300 mg./day, No intervention, Normouricemic
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Erectile Dysfunction, Metabolic Syndrome
The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction
Determine if men with erectile dysfunction (ED) are more likely to have insulin resistance compared to healthy controls.
- Conditions
- Erectile Dysfunction, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT00284960
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Type 2 Diabetes, Pre-diabetes
Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance
The incidence rate of type 2 diabetes in Thai populations is high and increasing every year. Cardiovascular disease is the main complication of this disease, which has been defined as an important cause of death among Diabetic…
- Conditions
- Type 2 Diabetes, Pre-diabetes, Insulin Resistance, Cardiovascular Risk
- Trial name
- NCT01052025
- Testing
- Curcumin
- Where
- Thailand
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Srinakharinwirot University
Diabete Type 2, Insulin Resistant Diabetes (Mellitus)
Study Evaluating the Safety and Feasibility of Endoscopic Duodenal Injections of Autologous Mesenchymal Stem Cells
Type 2 Diabetes Mellitus (T2DM) pathogenesis increasingly involves "diabetic duodenopathy," characterized by proximal intestinal immune and epithelial dysregulation.
- Conditions
- Diabete Type 2, Insulin Resistant Diabetes (Mellitus), Obesity
- Trial name
- STEM-DM (NCT07344324)
- Testing
- endoscopic duodenal injection of ADMSCs
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Insulin Sensitivity, Obstructive Sleep Apnea
Obesity, Sleep Apnea, and Insulin Resistance
Obstructive sleep apnea (OSA) and type 2 diabetes confer increasing economic, social, and public health burdens in the United States.
- Trial name
- NCT02192684
- Testing
- Pioglitazone
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity
Physical Activity in the Treatment of Obesity
Although exercise is widely regarded as a key component in obesity treatment, few individuals seem able to adhere to exercise programs over time.
- Trial name
- CHANGE (NCT00615238)
- Testing
- Diet plus continuous bouts, Diet plus short bouts, Diet plus moderate lifestyle activity
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes
Comparison Study of Insulin Glargine and NPH Insulin
This study will compare the safety, effectiveness, and cost of two different types of long-acting insulin.
- Trial name
- NCT01854723
- Testing
- Switching to NPH insulin, Continuation of insulin glargine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Providence Health & Services
Diabetes
Monitoring the Infusion Pressure in Insulin Infusion Sets in Healthy Adults
The purpose of this study is to compare the in-line fluid pressure (pressure of the fluid going through the tubing) and leakage (observation of fluid on and around the device) during and after subcutaneous infusion using two…
- Trial name
- NCT02382536
- Testing
- BD Scarlett Infusion set, Medtronic QuickSet Infusion Set
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Becton, Dickinson and Company
Diabetes Mellitus, Type 2, Diabetes
Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes, Type 2 Diabetes, Pre Diabetes
- Trial name
- NCT06657209
- Testing
- Insulin resistance testing, OGTT, Fat biopsy
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Stanford University
Polycystic Ovary Syndrome
Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women
The goal of this three-armed randomized controlled trial is to establish the relative roles of treatment of hyperandrogenism versus obesity (as the largest modifiable factor contributing to insulin resistance) in treating…
- Trial name
- OWL-PCOS (NCT00704912)
- Testing
- Orlistat/Meal Replacement/Lifestyle Modification, Loestrin 1/20, Combination of treatments
- Where
- 2 sites in United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Gestational Diabetes Mellitus (GDM)
Gestational Diabetes and Human Milk Composition Study
This study aims to compare hormone levels and milk composition in women with and without gestational diabetes through postpartum human milk and blood samples.
- Trial name
- NCT07051681
- Testing
- Individualized Medical Nutrition Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marmara University
Diabetes Mellitus, Type 2
Beta Cell Relieving and Cardiovascular Protective Effects of LANTUS Treatment in Type 2 Diabetes Patients
The purpose of this phase IV clinical trial is to investigate the effect of Insulin glargine + metformin treatment vs. sulfonylurea + metformin treatment vs. DPP-4 + metformin treatment vs.
- Trial name
- NCT01206712
- Where
- Germany
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- ikfe-CRO GmbH
Knowledge on Insulin Therapy, Practice on Insulin Administration
Tittle: Effect of Video-Based Health Education Intervention on Insulin Therapy Among Adults With Diabetes Mellitus in Dhulikhel Hospital
Insulin is an essential therapy for treating diabetes, but many patients lack standard insulin injection skills. Learning the method of proper insulin injection technique is crucial for diabetes patients as it promotes treatment…
- Trial name
- NCT06435598
- Testing
- video-based health education
- Where
- Nepal
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kathmandu University School of Medical Sciences
Obesity, Insulin Resistance
Vitamin K to Slow Progression of Dyslipidemia and Diabetes Risk (Vita-K 'n' Kids Study II)
Animal studies have found that vitamin K-dependent proteins matrix Gla protein and osteocalcin beneficially influence lipid and glucose metabolism, respectively.
- Conditions
- Obesity, Insulin Resistance, Obesity in Diabetes, Nutritional and Metabolic Diseases
- Trial name
- NCT02959762
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45-mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Type 1 Diabetes
Liraglutide in the Treatment of Type 1 Diabetes Mellitus
Hypothesis 1: Treatment with Liraglutide in patients with type 1 diabetes decreases fasting, postprandial and the overall mean glucose concentrations.
- Trial name
- NCT01722266
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Type 1 Diabetes, Prediabetic State
Trial of Early Initiation of CGM-Guided Insulin Therapy in Stage 2 T1D
This protocol is an intervention study to determine the best education and monitoring strategy for children ages 2-20 years with pre-symptomatic type 1 diabetes (T1D) because there currently exists no clinical guidelines for…
- Conditions
- Type 1 Diabetes, Prediabetic State, Dysglycemia, Autoimmune Diabetes
- Trial name
- TESS (NCT04335513)
- Testing
- Early CGM-guided education and initiation of insulin therapy., Usual care: glucometer surveillance and basic education.
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver