Clinical trials: Intensive Care Unit (ICU)
Critical Illness
Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery
We hypothesize that measurements of interstitial fluid (ISF) glucose by the FreeStyle Navigator (Abbot Diabetes Care), a continuous glucose monitoring system, will correlate with blood glucose (BG) values in surgical and ICU…
- Trial name
- NCT00694473
- Testing
- Freestyle Navigator
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Massachusetts General Hospital
Hypotension
Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
The use of peri-arrest bolus epinephrine (PBE) has emerged as a rescue strategy for life-threatening hypotension in pediatric intensive care units (ICU) despite scant published data supporting its use in this setting.
- Trial name
- EPIDose (NCT05327556)
- Testing
- Epinephrine 0.5 mcg/kg, Epinephrine 1 mcg/kg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Blood Pressure, Surgery
Comparison of Non-invasive and Invasive Blood Pressure Monitors
To compare a noninvasive and continuous radial artery blood pressure measurements utilizing ViTrack (developed by Dynocardia) to the standard of care radial artery catheterization, in patients undergoing surgery or those who are…
- Conditions
- Blood Pressure, Surgery, Intensive Care Unit
- Trial name
- NCT04506775
- Testing
- ViTrack, Radial artery catheterization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Massachusetts, Worcester
Bed-ridden Patient, Solid Organ Transplant
Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study
1. Study Title: Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study 2.
- Conditions
- Bed-ridden Patient, Solid Organ Transplant, Post Critical Care
- Trial name
- NCT06937463
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Asan Medical Center
Gram-Negative Bacterial Infections
An Observational Pharmacokinetic Sudy of Ceftolozane-Tazobactam in Intensive Care Unit in Patients With and Without CRRT
The purpose of this study is to try to find out how critically ill patients receiving the antibiotic, ceftolozane-tazobactam, process it in their body.
- Trial name
- CT-PK (NCT02962934)
- Testing
- Non CRRT group, CRRT group
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Royal Brisbane and Women's Hospital
Candidiasis
Early Clinical Experience With Anidulafungin In Patients With Liver Disease In The United Kingdom
The purpose of this study is to describe the real world effectiveness of anidulafungin in clinical practice in a large Liver Unit in the United Kingdom.
- Trial name
- NCT01202253
- Testing
- anidulafungin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Pfizer
Cardiogenic Pulmonary Oedema
Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
The aim of the present study was to demonstrate that an Non-Invasive Ventilation (NIV) performs better than a Continuous Positive Airway Pressure (CPAP) in the management of Cardiogenic Pulmonary Edema (CPE) within an Intensive…
- Trial name
- NCT02977572
- Testing
- Non-Invasive Ventilation, Continuous Positive AirwayPressure CPAP
- Volunteers
- 114 people
- Sponsor
- Hospital General Universitario de Castellón
Retinopathy of Prematurity
Bevacizumab Eliminates the Angiogenic Threat for Retinopathy of Prematurity
The purpose of this study was to determine the efficacy and additional advantages of intravitreal bevacizumab in the treatment of ROP for both Zone I and Zone II Posterior.
- Trial name
- BEAT-ROP (NCT00622726)
- Testing
- Bevacizumab, Conventional Laser for ROP
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Septic Shock
PK Analysis of Piperacillin in Septic Shock Patients
Antibiotic dosing in septic shock patients poses a challenge for clinicians due to the pharmacokinetic changes seen in this population.
- Trial name
- NCT02306928
- Testing
- Blood draw
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Invasive Candidiasis
β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) Patients
This is a single center, prospective, open label assessment of β-D-glucan surveillance with preemptive anidulafungin therapy versus standard care for the prevention of invasive candidiasis in at-risk surgical intensive care unit…
- Trial name
- NCT00672841
- Testing
- Preemptive Therapy with Anidulafungin, Empiric antifungal therapy based on physician discretion.
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Duke University
Analgesia
Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)
This study will be a multicentre randomized, open-label, phase IIIb study. This study will evaluate two different techniques of sedation: an analgesia based regimen with remifentanil versus a conventional sedation based regimen…
- Trial name
- NCT00436345
- Testing
- Remifentanil, Propofol
- Where
- 6 sites in Italy
- Volunteers
- 39 people
- Sponsor
- GlaxoSmithKline
Critical Illness, Psychological Distress
Messy Memories: Mobile Application Therapy Following Critical Illness
The overall goal of this study is to determine whether English-speaking adults who were discharged from an intensive care unit (ICU) at least one month ago and have some level of distress related to their ICU experience will be…
- Conditions
- Critical Illness, Psychological Distress, Health Behavior
- Trial name
- NCT05849454
- Testing
- Messy Memories Intervention
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
Child
Femoral Central Venous Access Comparison of 2 Methods
The purpose of this study is to compare the effectiveness and safety of the installation of femoral central venous catheter (CVC) ultrasound-guided real-time 2D versus the landmark method
- Trial name
- NCT02318940
- Testing
- central venous catheter
- Where
- 2 sites in Chile
- Volunteers
- 99 people
- Sponsor
- University of Chile
Respiratory Failure
Facilitating EndotracheaL Intubation by Laryngoscopy Technique and Apneic Oxygenation Within the Intensive Care Unit: The FELLOW Study
Respiratory failure requiring endotracheal intubation occurs in as many as 40% of critically ill patients. Procedural complications including failed attempts at intubation, esophageal intubation, arterial oxygen desaturation…
- Trial name
- FELLOW (NCT02051816)
- Testing
- Video Laryngoscopy, Apneic Oxygenation, Direct Laryngoscopy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Circadian Rhythm Sleep Disorder, Unspecified
Feasibility Pilot of Bright Light in the Intensive Care Unit
To evaluate the feasibility of providing daytime bright light in the ICU in a pilot randomized controlled trial.
- Trial name
- NCT03568045
- Testing
- standard light, 10,000 lux bright light, 4 hours, 10,000 lux bright light, 8 hours
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Critical Illness
Exploration of Investigating ICU Mobilisation With Vasoactive Drugs
There is a need to know more about the safety of mobilizing intensive care unit (ICU) patients who are receiving vasoactive drugs that support the heart and blood pressure.
- Trial name
- NCT03869541
- Testing
- Mobilization
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Ventilation-Associated Pneumonia
Study of Impact of Not Measuring Residual Gastric Volume on Nosocomial Pneumonia Rates
Early enteral feeding is a key component of the management of critically ill patients receiving mechanical ventilation. However, enteral feeding has been associated with serious complications such as aspiration followed by…
- Trial name
- NUTRIREA1 (NCT01137487)
- Testing
- monitoring of residual gastric volume, not monitoring of residual gastric volume
- Where
- 6 sites in France
- Volunteers
- 452 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Surrogate Decision Makers, Prolonged Mechanical Ventilation
Improving Decision Making for Patients With Prolonged Mechanical Ventilation
Deciding about prolonged life support for critically ill patients can be very difficult. Therefore, the investigators are doing a study to see if an internet-based decision aid can improve the quality of decision making for…
- Trial name
- NCT01751061
- Testing
- Decision aid, Usual care
- Where
- 4 sites in United States
- Volunteers
- 416 people
- Sponsor
- Duke University
Acute Respiratory Failure
METEOR Think NIV Pilot
This study will pilot test three strategies designed to speed implementation of preventive post-extubation noninvasive ventilation (NIV): one control strategy (traditional online continuing medical education) and two novel…
- Trial name
- NCT04052542
- Testing
- Traditional online continuing education, Interprofessional education, Just-in-time education
- Where
- United States
- Volunteers
- 1,328 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh