Clinical trials: Intensive Care Unit Survivors
Brain Injury, Muscle Weakness
A Pilot Study of Rehabilitation Among Intensive Care Unit (ICU) Survivors: the RETURN Trial
Intensive care unit (ICU) hospitalization saves lives but often does so at a high personal cost to ICU survivors who frequently experience significant cognitive impairment and an array of physical and functional disabilities that…
- Trial name
- RETURN (NCT00715494)
- Testing
- Cognitive, physical, and functional rehabilitation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University
Intensive Care (ICU) Myopathy
Biomechanical Properties in Intensive Care Unit (ICU) Survivors 12-month After Discharge
Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report persevering limitation of physical capacity for years after discharge.
- Trial name
- NCT01364714
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Critical Illness, Stress, Psychological
Virtual Reality-Based Transitional Care for ICU Survivors
This study aims to evaluate the effectiveness of a virtual reality (VR)-based transitional care program for adult survivors of intensive care unit (ICU) care.
- Conditions
- Critical Illness, Stress, Psychological, Intensive Care Units
- Trial name
- VRICU (NCT07482722)
- Testing
- Virtual Reality-Based Transitional Care
- Where
- 2 sites in Taiwan
- Volunteers
- 150 people
- Sponsor
- Mackay Memorial Hospital
Critical Illness, Intensive Care Unit Delirium
Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction in ICU Survivors, 2nd Study
This BRAIN-ICU-2 study [Bringing to light the Risk factors And Incidence of Neuropsychological dysfunction (dementia) in ICU Survivors, 2nd Study] is in direct response to PAR-17-038 and will determine ICU patients' main paths to…
- Trial name
- BRAIN-2 (NCT04305600)
- Where
- 2 sites in United States
- Volunteers
- 567 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis, Post Intensive Care Unit Syndrome
Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Muciniphila.
The goal of this clinical trial is to learn if daily oral supplementation with pasteurized Akkermansia muciniphila (PAM), an EFSA-approved food supplement, can support recovery in adults who have recently been treated in the ICU…
- Conditions
- Sepsis, Post Intensive Care Unit Syndrome, Critical Illness, Microbiome Dysbiosis
- Trial name
- PAM-ICU (NCT07295353)
- Testing
- Pasteurized Akkermansia muciniphila
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Adult Patients, Intensive Care Unit
Functional Recovery Over the First Year After ICU Discharge
Intensive Care Unit Acquired Delirium (ICU-AD) and Intensive Care Unit Acquired Weakness (ICU-AW) are common in critically ill, mechanically ventilated adult patients.
- Trial name
- NCT04206306
- Where
- Taiwan
- Volunteers
- 407 people
- Sponsor
- National Taiwan University Hospital
Post Intensive Care Unit Syndrome
Web-based Follow-up to Former ICU Patients
This study evaluates if a web-based 1-year programme is a useful method for follow-up intensive care survivors with short ICU-stay.
- Trial name
- WIVA (NCT04317144)
- Testing
- Web-based follow-up programme., No follow-up
- Where
- Sweden
- Volunteers
- 330 people
- Sponsor
- Uppsala University
Intensive Care Unit Delirium, Intensive Care Acquired Cognitive Impairment
Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (VR-Cog)
The purpose of this study is to measure the feasibility, acceptability of virtual reality (VR) brain games and estimate their effect on memory, attention, and mood for ICU survivors.
- Conditions
- Intensive Care Unit Delirium, Intensive Care Acquired Cognitive Impairment, Post Intensive Care Unit Syndrome, Virtual Reality Cognitive Training
- Trial name
- NCT07496255
- Testing
- VR-based cognitive training program, VR-based attention control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Delirium, Cognition Disorders
The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors
The primary purpose of this proposal will be to identify potentially modifiable risk factors of long-term cognitive impairment (i.e. development of delirium and exposure to sedative and analgesic medications) in ICU patients.
- Conditions
- Delirium, Cognition Disorders, Dementia
- Trial name
- BRAIN-ICU (NCT00392795)
- Where
- 2 sites in United States
- Volunteers
- 826 people
- Sponsor
- Vanderbilt University Medical Center
Post-acute COVID-19 Syndrome, Long-COVID
Sociodemographic, Clinical, Quality of Life and Health Care Conditions in COVID-19 Survivors.
Sociodemographic, Clinical, Quality of Life, and Health Care Conditions After Hospital Discharge in Patients Who Required Admission to the Intensive Care Unit for COVID-19 at the Hospital Universitario Nacional Between April 2020…
- Conditions
- Post-acute COVID-19 Syndrome, Long-COVID, COVID-19, Long COVID
- Trial name
- NCT05185674
- Testing
- Exposure: Coronavirus disease 2019 (COVID-19)
- Where
- Colombia
- Volunteers
- 114 people
- Sponsor
- Javier Eslava
Unable to Sit-to-stand, ICU Survivor
Effect of Sit-to-Stand Intervention in the Intensive Care Unit Survivors
"Sit-to-stand" is key to independent living. For intensive care unit (ICU) survivors, failure to perform sit-to-stand results in bed-bound status, unable participating in important activities of daily living (ADLs) or…
- Trial name
- NCT04640441
- Testing
- Sit-to-stand Intervention
- Where
- Taiwan
- Volunteers
- 246 people
- Sponsor
- National Taiwan University Hospital
Covid19, Neurocognitive Dysfunction
Long-term Neurocognitive and Psychiatric Consequences in Severe COVID-19 Survivors.
Long-term neurocognitive and psychiatric consequences of COVID-19 remain mostly unknown to date. It has been reported that coronaviruses cause direct central nervous system infection (Needham et al. 2020).
- Trial name
- NPQCOVID (NCT05019300)
- Testing
- Exposure: COVID-19 severity
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Intensive Care Unit Syndrome, Post-intensive Care Syndrome
Neurological Blood-based Biomarkers and Cognitive Disorders in Critically Ill Survivors.
Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β…
- Conditions
- Intensive Care Unit Syndrome, Post-intensive Care Syndrome, Cognitive Disorder
- Trial name
- COGNISI (NCT05953311)
- Testing
- Blood analysis, Cognitive tests
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University of Liege
Intensive Care Units
Long-term Outcomes of Critical Illness Survivors
The goal of this study is to assess the Long-term Outcomes of Critical Illness Survivors,including physical, psychological, and cognitive sequelae.
- Trial name
- NCT03940755
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Jian-jun Yang
Intensive Care Unit Survivors, Informal Caregivers (Family and Friends)
Improving Psychological Distress Among Critical Illness Survivors and Their Caregivers
Patients who receive life support in intensive care units commonly suffer from persistent depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms after discharge.
- Trial name
- NCT01983254
- Testing
- coping skills training, education program
- Where
- 4 sites in United States
- Volunteers
- 417 people
- Sponsor
- Duke University
Post-Intensive Care Syndrome (PICS)
MONITOR-IC: Determining and Improving Long-term Consequences of ICU Care
Due to advances in critical care medicine, more patients survive their critical illness. However, intensive care unit (ICU) survivors often experience long-term physical, cognitive and mental problems, summarized as post…
- Trial name
- MONITOR-IC (NCT03246334)
- Where
- Netherlands
- Volunteers
- 50,000 people
- Sponsor
- Radboud University Medical Center
Systemic Lupus Erthematosus, Childhood-onset Systemic Lupus Erythematous
Gyrotonic Exercise in Lupus Adolescents Who Survived From Intensive Care
lupus adoelscented who recently survive from intenive care unit usually complain postintenive care unit syndrome in addition to stress, fatigue, low life quality, depression, low physical performance, low grip strenght, insomnia…
- Conditions
- Systemic Lupus Erthematosus, Childhood-onset Systemic Lupus Erythematous, Intensive Care Unit Survivors, Adolescents
- Trial name
- NCT07833020
- Testing
- Gryotonic exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Stress Disorders, Post Traumatic, Anxiety
Preventing Post-traumatic Stress in ICU Survivors: A Pilot Randomized Controlled Trial of ICU Diaries
The main objective of the study is to test the feasibility of the ICU diaries intervention in the ICU. The investigators do not have sufficient power to detect differences in the hypotheses below, but will use the present pilot…
- Conditions
- Stress Disorders, Post Traumatic, Anxiety, Depression, Quality of Life
- Trial name
- NCT02067559
- Testing
- ICU Diary, Psychoeducation
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- University of Manitoba
Critical Illness, Kidney Injury
Assessment of Kidney Function and Osteomuscular Status After Critical Care
This observational study aims to assess kidney function through direct glomerular filtration rate (GFR) using iohexol clearance, compared to estimated GFR based on creatinine and cystatin C equations.
- Conditions
- Critical Illness, Kidney Injury, Muscle Loss, Bone Loss
- Trial name
- NCT04980092
- Testing
- one-year follow-up
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University of Liege
Gastroesophageal Reflux Disease, Critically Ill
Gastroesophageal Reflux Disease (GERD) Among ICU Survivors
Gastro-esophageal reflux disease (GERD) is a condition characterized by reflux of stomach contents causing troublesome symptoms and complications.
- Trial name
- NCT05193266
- Where
- India
- Volunteers
- 116 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences