Clinical trials: Intensive Care Units (ICUs)
COVID-19 Acute Respiratory Distress Syndrome
Rehabilitation of Critically Ill Patients With SARS-CoV-2 Variants in ICU With Limited Resources
Acute rehabilitation in critically ill patients can improve post-intensive care unit (post-ICU) physical function. Scientific evidence has considered neuromuscular electrical stimulation (NMES) as a promising approach for the…
- Trial name
- NCT05450120
- Testing
- Functional Rehabilitation, Neuromuscular Electrical Stimulation
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Universidade Federal de Sao Carlos
Daptomycin, Real-world Study
Real-world Daptomycin Use in Chinese ICUs
Analyze the effectiveness and safety of Daptomycin(Jiangsu Hengrui Medicine Co., Ltd) in Gram-positive infections in Chinese Intensive Care Units by using the real-world data platform, https://rws.scccmqc.com.
- Conditions
- Daptomycin, Real-world Study, Intensive Care Unit
- Trial name
- NCT03588637
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure.
- Conditions
- Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema, Weaning Failure of Mechanical Ventilation, Spontaneous Breathing Test
- Trial name
- ATARI (NCT06923267)
- Testing
- No Pressure Support No Positive End Expiratory Pressure Spontaneous Breathing Trial, Pressure Support Spontaneous Breathing trial, Humidified High Flow Spontaneous Breathing Trial
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Critically Ill, Hyperglycemia
Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2
The Purpose of this study is to: 1. Introduce the refined, validated, and safe computerized bedside decision support tool for blood glucose management in critically ill adult and pediatric ICU patients that was studied in Phase 1…
- Trial name
- NCT00654797
- Testing
- glucose control with computer generated recommendations
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Intermountain Health Care, Inc.
Pressure Injury, Reliability and Validity
Adaptation of the Intensive Care Unit-specific Pressure Injury Risk Scale to Turkish (RAPS-ICU)
The aim of this study was to evaluate the translation, cross-cultural fit, and psychometric properties of the ICU-specific pressure injury risk scale
- Conditions
- Pressure Injury, Reliability and Validity, Intensive Care Units (ICUs), Assessment Scale
- Trial name
- NCT06908512
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Harran University
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Respiration, Artificial, Acute Hypoxemic Respiratory Failure
Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory Failure
The goal of this observational study is to estimate the prevalence of the use of protective ventilation with low tidal volume ventilation in the transition of spontaneous ventilation modes in patients with hypoxemic acute…
- Conditions
- Respiration, Artificial, Acute Hypoxemic Respiratory Failure, Respiratory Insufficiency
- Trial name
- SPIRAL (NCT06042036)
- Testing
- Spontaneous mode of mechanical ventilation
- Where
- 10 sites in Argentina, Bolivia and 8 more
- Volunteers
- 431 people
- Sponsor
- University of Sao Paulo General Hospital
Pediatric Patient (1m-21y), ICU Admission
Pediatric Intensive Care Units (ICUs) at Emory-Children's Center Glycemic Control: The PedETrol Trial
The primary goal of this project is to determine whether normalizing hyperglycemia is a safe approach to improve multisystem organ function in critically ill children requiring intensive care.
- Conditions
- Pediatric Patient (1m-21y), ICU Admission, Hyperglycemia
- Trial name
- PedETrol (NCT01116752)
- Testing
- Active Glycemic Control Strict (80-140mg/dL) vs. Conservative (190-220mg/dL) (with or without Continuous Glucose Monitoring)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Indiana University
Intensive Care Units (ICUs)
Body Lateralization and Its Effects on Respiratory Drive, Ventilation, and Pulmonary Aeration in Critically Ill Patients
The goal of this quasi-experimental study is to investigate how different body positions, performed through Automatic Lateralization Therapy, affect respiratory drive, ventilation, and pulmonary aeration in critically ill adult…
- Trial name
- LATLUNG (NCT07323472)
- Testing
- Automatic Lateralization Therapy, Supine Positioning
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Pernambuco
Critical Illness, Intensive Care Units (ICUs)
Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit
The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing…
- Conditions
- Critical Illness, Intensive Care Units (ICUs), Weaning Failure, Mechanical Ventilation
- Trial name
- SERA-Effort (NCT07109570)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Pressure Ulcer (PU), Hemofiltration
Evaluation of Pressure Injury Risks in Hemofiltration
Purpose: Patients treated in intensive care units are at high risk of developing pressure injuries due to their critical illnesses as well as many risk factors such as immobility, changes in level of consciousness, hemodynamic…
- Conditions
- Pressure Ulcer (PU), Hemofiltration, Intensive Care Units (ICUs)
- Trial name
- NCT07825727
- Testing
- Identifying the risks of pressure injuries
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people
- Sponsor
- Ogr. Uyesi Naile
Mucosal Wound, Mucosal Erosion
The Effect of Changes in the Frequency of Endotracheal Tube Repositioning in Intensive Care Units on the Prevention of Oral Mucosal Pressure Injuries
Intensive care units (ICUs) are care centers equipped with a wide range of technological tools and devices used to provide the highest level of care to individuals whose lives are at risk, requiring a multidisciplinary team…
- Conditions
- Mucosal Wound, Mucosal Erosion, Mucosal Irritation, Endotracheal Intubation Fixation
- Trial name
- PreventionMMPI (NCT07390162)
- Testing
- Changes in the frequency of endotracheal tube repositioning
- Volunteers
- 230 people
- Sponsor
- Hacettepe University
Covid19, Acute Respiratory Failure
Survival Rates and Longterm Outcomes After COVID-19
The study 'Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUs' is a national observational study, including patients admitted to a Norwegian ICU between March 2020 and March 2021.
- Conditions
- Covid19, Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Post Intensive Care Unit Syndrome
- Trial name
- NCT04601090
- Testing
- ICU treatment
- Where
- Norway
- Volunteers
- 860 people
- Sponsor
- Oslo University Hospital
Pneumonia, Ventilator-Associated, Stenotrophomonas Infection
Pneumonia Due to Stenotrophomonas Maltophilia in ICUs
Pneumonia is a major cause of ICU admission, or may complicate ICU course. Among the causative pathogens, Stenotrophomonas Maltophilia is a rare pathogen, but affects usually patients with chronic pulmonary co-morbidities, or…
- Conditions
- Pneumonia, Ventilator-Associated, Stenotrophomonas Infection, Critical Illness, Pneumonia, Bacterial
- Trial name
- RETROSTENO (NCT03506191)
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Work Stress
Construction and Validation of a Stress Scale Specific to ICUs: Perceived Stressors in Intensive Care Units (PS-ICU)
This study aims to construct and validate an international professional perceived stress scale specific to intensive care units: the PS-ICU Scale (Perceived Stressors in Intensive Care Units).
- Trial name
- PS-ICU (NCT02853851)
- Testing
- interviews
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Respiratory Distress Syndrome (ARDS), Intensive Care Units (ICUs)
Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol
Despite best supportive care, mortality of the Acute Respiratory Distress Syndrom (ARDS) remains high. In the absence of specific treatments, providing safe and efficient mechanical ventilation (MV) is key to survival.
- Trial name
- PEPER (NCT06849570)
- Testing
- Minimal distension, Maximal Recruitment, Prone position + early NMBAs
- Where
- 29 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Enteral Feeding, Ventilator-Associated Pneumonia
Impact of Intermittent and Continuous Enteral Feeding on Ventilator-associated Pneumonia in Pediatric ICUs
Mechanical ventilation has become one of the most important supportive treatment methods to save the life of critically ill children over time.
- Trial name
- NCT02973347
- Testing
- Intermittent enteral feeding, Continuous enteral feeding
- Volunteers
- 400 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Sars-CoV2, Covid-19
Cardiac Arrest Incidence and Outcome Among Patients With COVID-19 in French ICUs
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19) pandemic.
- Trial name
- ACICOVID (NCT04373759)
- Testing
- Cardiopulmonary resuscitation, Modified Rankin score
- Where
- 36 sites in France, Martinique
- Volunteers
- 186 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Carbapenem Resistant Enterobacteriaceae Infection, Artificial Intelligence
A Novel Approach to Antimicrobial Resistance: Machine Learning Predictions for Carbapenem-Resistant Klebsiella in ICUs
The aim of this study to predict carbapenem resistant Klebsiella spp. earlier in our patients monitored in our Intensive Care Unit in the future, using artificial intelligence.
- Conditions
- Carbapenem Resistant Enterobacteriaceae Infection, Artificial Intelligence, Intensive Care Unit
- Trial name
- ICU (NCT05985057)
- Testing
- Artificial intelligence
- Where
- Turkey (Türkiye)
- Volunteers
- 289 people
- Sponsor
- Kocaeli University