Clinical trials: Interaction
Trauma Injury, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery.
- Conditions
- Trauma Injury, Trauma, Critical Illness, Microbiome
- Trial name
- NCT06606119
- Testing
- Data and tissue collection
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- University of Florida
Breast Cancer
Docetaxel, Doxorubicin, and Cyclophosphamide in Treating Women With Advanced Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, doxorubicin, and cyclophosphamide, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00074139
- Testing
- cyclophosphamide, docetaxel, doxorubicin hydrochloride
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Central Nervous System Diseases
CKD-355 Drug-drug Interaction Study (CKD-355 DDI P1)
The purpose of this study is to evaluate a pharmacokinetic drug interaction between D797 of D324 in healthy volunteers
- Trial name
- NCT03569579
- Testing
- Memantine Tab. 10mg, Memantine Tab. 10mg + Donepezil Tab. 10mg
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Implantable Defibrillator User, Distress
A Personalized and Interactive Web-based Health Care Innovation to Advance the Quality of Care
This study evaluates the clinical efficacy and cost-effectiveness of the ACQUIRE-ICD care innovation as add-on to usual care as compared to usual care alone in patients with an implantable cardioverter defibrillator.
- Trial name
- ACQUIRE-ICD (NCT02976961)
- Testing
- Supportive care
- Where
- 5 sites in Denmark
- Volunteers
- 478 people
- Sponsor
- Susanne Schmidt Pedersen
Solid Tumor Cancer Treatment With Immunotherapy
Gut Microbiota (GM) Biodiversity in Patients With Solid Tumors Treated With Immune Checkpoint Inhibitors (ICIs): a Monocenter Prospective Study to Identify the Interactions Between GM and ICIs
Although it is a milestone in the treatment of solid neoplasms, Immunotherapy (ICI) is still burdened by low response rate to the treatment and the occurrence of immune-related adverse events (irAEs).
- Trial name
- GM&ICI (NCT07236983)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Methamphetamine Dependence
Methamphetamine-Quetiapine Interactions in Humans
This study will test the ability of a medicine (Quetiapine) that is used to treat schizophrenia or bipolar disorder to reduce the effects of methamphetamine that make it difficult for users to stop using it.
- Trial name
- NCT00567866
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arkansas
Colorectal Cancer
Diet, Genes and Colorectal Cancer - With Focus on Toll-like Receptor Polymorphisms
The aim of this study is to investigate the interaction between diet - primary meat and fiber - and polymorphisms in Toll-like receptors in relation to risk of colorectal cancer in a Danish prospective cohort.
- Trial name
- NCT03250637
- Testing
- Observational
- Volunteers
- 2,895 people
- Sponsor
- University of Southern Denmark
Healthy Participants
A Drug-Drug Interaction Study to Evaluate the Effect of Itraconazole on the Pharmacokinetic Profile of Etrumadenant in Healthy Adult Participants
This study will evaluate the effect of multiple oral doses of itraconazole, on the pharmacokinetics of etrumadenant when etrumadenant is administered as a single dose in healthy adult participants.
- Trial name
- NCT05154136
- Testing
- Etrumadenant, Itraconazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arcus Biosciences, Inc.
Prostate Cancer (Post Prostatectomy)
The Application of Somatosensory Interactive Pelvic Floor Muscle Training for Stress Urinary Incontinence in Men Underwent Radical Prostatectomy
The study aims to compare the efficacy of different pelvic floor muscle training (PFMT) modes on improving urinary incontinence (UI) recovery in prostate cancer (PCa) patients after radical prostatectomy (RP).
- Trial name
- NCT06740071
- Testing
- somatosensory interactive pelvic floor muscle training, pelvic floor magnetic stimulation therapy, standard pelvic floor muscle training
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Perfusion; Complications, Mechanical Ventilation Complication
A Non-invasive Evaluation of Kidney-Lung Interactions
The present study aims to evaluate, with non-invasive methods, the relationships existing between PEEP and renal perfusion in patients undergoing surgery and requiring ventilatory support and monitoring in intensive care.
- Trial name
- KIDNEY-LUNG (NCT03747731)
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- St. Bortolo Hospital
Healthy Male Subjects
Investigate a Interaction of Candesartan and Atorvastatin in Healthy Male Sugjects
primary object : Evaluate pharmacokinetic drug-drug interaction of Candesartan and Atorvastatin
- Trial name
- NCT02609711
- Testing
- Candesartan cilexetil
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Type 2 Diabetes Mellitus
Study on Drug Interaction of HRS-1780 Tablets, Henagliflozin Tablets, Metformin Tablets and HRS-7535 Tablets in Healthy Human
This study was designed as a single-center, single-arm, open, fixed-sequence, self-controlled trial in healthy subjects.
- Trial name
- NCT06495931
- Testing
- HRS-1780 tablets, HR20033 tablets, HRS-7535 tablets
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Hyperlipidemias, Hypertension
Evaluating the Pharmacokinetic Interaction Between AD-2011 and AD-2012
The purpose of this study is to evaluate the Pharmacokinetic Interaction Between AD-2011 and AD-2012 in healthy male volunteers.
- Trial name
- NCT03586037
- Testing
- AD-2011 10/20 mg, AD-2012 80mg, AD-2011 10/20 mg + AD-2012 80mg
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Neoplasms
Effect of Regorafenib on Digoxin and Rosuvastatin in Patients With Advanced Solid Malignant Tumors.
Evaluate the effect of regorafenib on the pharmacokinetics of digoxin (P-gp substrate : P-glycoprotein) and rosuvastatin (BCRP substrate: Breast cancer resistant protein) by comparing their Area under time curve (AUC(0-24)) and…
- Trial name
- NCT02106845
- Testing
- Digoxin, Rosuvastatin, Regorafenib (Stivarga, BAY73-4506)
- Where
- 5 sites in Germany, Hungary
- Volunteers
- 42 people
- Sponsor
- Bayer
Gastroesophageal Reflux, Gastric Ulcer
Safety of Rabeprazole in Patients Under Multiple Treatments
The purpose of this study is to evaluate the safety of rabeprazole 20mg/day in polymedicated patients and to examine the necessity of adjusted dosage in both therapies (rabeprazole and concomitant drug).
- Trial name
- NCT00511745
- Testing
- Rabeprazol
- Volunteers
- 2,157 people
- Sponsor
- Janssen-Cilag, S.A.
Pain
MUSIQ: MusicStudyImpactQualitative
Dressing repairs cause distress and pain in children. Although drug analgesia is commonly used, some young children experience pain, distress and agitation.
- Trial name
- MUSIQ (NCT04671745)
- Testing
- Music, No music
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Perceived Stress, Positive and Negative Affect
Efficacy of Interactive Audio-based Mindfulness ChatGPT-Powered Intervention on Well-being
Brief mindfulness intervention is a short form is a form of short-duration practice, typically delivered for around 30 minutes or less (Howarth et al., 2019).
- Conditions
- Perceived Stress, Positive and Negative Affect, State Anxiety, Self Control
- Trial name
- NCT07333365
- Testing
- Interactive Mindfulness Breathing ChatGPT-Powered Intervention, Interactive Mind Wandering ChatGPT-Powered Intervention, Mindfulness Breathing Audio-only
- Where
- Singapore
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Singapore Management University
Immunization; Infection, SMS
Use of SMS and Interactive Reminders to Improve Timely Immunization Coverage
Pakistan has one of the highest infant mortality rates in the world. One child in eleven dies before their fifth birthday. In part, this is due to the low coverage rate of routine childhood immunizations.
- Trial name
- NCT03379467
- Testing
- SMS Reminder, Interactive Reminder
- Volunteers
- 655 people, healthy volunteers welcome
- Sponsor
- Interactive Research and Development
Violence in Adolescence, Social Interaction
Strengthening Adolescent-Adult Networks to Reduce Youth Violence
This pilot community-partnered cluster-randomized trial will examine the feasibility and acceptability of a social network-based youth violence prevention program called Strengthening Connections for Change for youth ages 13-17…
- Conditions
- Violence in Adolescence, Social Interaction, Coping Skills, Adolescent Behavior
- Trial name
- NCT05185453
- Testing
- Strengthening Connections for Change, Job Readiness Training
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Autism Spectrum Disorder
Effectiveness Trial of Mobile ESI for Toddlers With Autism Identified by Early Screening in Primary Care
The goal of this collaborative R01 is to demonstrate the therapeutic value and community-wide implementability of an early intervention (EI) platform for toddlers with autism spectrum disorder (ASD) that is completely virtual…
- Trial name
- ESI-MC (NCT05456139)
- Testing
- Treatment as Usual, Early Social Interaction Mobile Coaching (ESI-MC)
- Where
- 8 sites in United States
- Volunteers
- 52 people
- Sponsor
- Florida State University
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