Clinical trials: Interaction
Patient Ventilator Interactions, Spontaneous Breathing Trial
Entropy Analysis and Complex Patient-ventilator Interactions During Mechanical Ventilation
Complex patterns of patient-ventilator interactions could be miscalculated by visual observation of mechanical ventilator screens or current algorithms based on physiologic waveforms to detect patient-ventilator asynchronies.
- Trial name
- ENTROPY-ICU (NCT04128124)
- Testing
- processing signals of airway pressure and airway flow to calculate entropy
- Where
- Spain
- Volunteers
- 107 people
- Sponsor
- Corporacion Parc Tauli
Quality of Life, Women Health
Evaluation of Quality of Life in Women
300 women will be evaluated in this study. Their quality of life, level of physical activity, Social Functioning, levels of depression and musculoskeletal status will be assessed.
- Conditions
- Quality of Life, Women Health, Social Interaction
- Trial name
- NCT04164628
- Testing
- Quality of life assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Gout, Food-drug Interaction
Study to Investigate the Effects of Food on Relative Bioavailability of ABP-671 Tablets in Healthy Subjects
This is a single center, open-label, single-dose, 2-way randomized crossover design in which 12 healthy subjects will be randomized to 1 of 2 treatment sequences (AB or BA).
- Trial name
- NCT04303039
- Testing
- ABP-671
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Atom Therapeutics Co., Ltd
Social Interaction
The Effects of Social Role Participation on Life Quality
The study was carried out among 100 RA patients (age from 20 to 70 years) by fulfilling the American College of Rheumatology 1987 revised criteria admitted to our outpatient clinic.
- Trial name
- NCT04426370
- Testing
- Observational
- Volunteers
- 195 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Mother-Infant Interaction, Postnatal Depression
Effects of Type of Delivery Mode and Gestational Age on Maternal Bonding
To evaluate the effects of gestational age and other factors on maternal attachment relationship. There are different results in studies examining the effects of birth type on postpartum depression and mother-infant interaction.
- Conditions
- Mother-Infant Interaction, Postnatal Depression, Postpartum Anxiety
- Trial name
- NCT04396509
- Testing
- Maternal Attachment Inventory Score
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Breastfeeding, Exclusive, Mother-Infant Interaction
Proyecto BEBE: The Effect of Babywearing Education on Breastfeeding Exclusivity
To test the hypothesis that increased mother-infant physical contact affects the likelihood of mothers exclusively breastfeeding their child for the first six months of life, the investigators will randomly assign half of the…
- Conditions
- Breastfeeding, Exclusive, Mother-Infant Interaction, Postpartum Depression
- Trial name
- NCT04376021
- Testing
- Babywearing
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Nurturely
Food-drug Interaction
Effect of Pineapple Juice on the Pharmacokinetics of Celecoxib and Montelukast in Humans
Pineapple (Ananas comosus) is a tropical fruit that is rich in antioxidents, enzymes and vitamins. It is used worldwide due to their anti-inflammatory and analgesic properties.
- Trial name
- NCT04374981
- Testing
- Celecoxib 100mg, Montelukast 10mg
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Physical Activity
The Stealth Pet Obedience Training Study
Americans love pets. Nearly 1 in 2 American households (44%) own at least one pet dog and more than 1 in 3 (35%) own a cat. The bond people form with their pets can be powerful and can provide many mental and physical health…
- Trial name
- SPOT (NCT04329741)
- Testing
- 6-week basic dog obedience training course
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Latent Tuberculosis, Human Immunodeficiency Virus
Doravirine, Rifapentine and Isoniazid Interaction
Drug therapy for persons living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) co-infected with latent tuberculosis infection (LTBI) is complex.
- Conditions
- Latent Tuberculosis, Human Immunodeficiency Virus, Rifamycins Causing Adverse Effects in Therapeutic Use, Drug Interaction Potentiation
- Trial name
- DORIIS (NCT03886701)
- Testing
- Doravirine (DOR), Rifapentine (RPT), Isoniazid (INH)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Walter K. Kraft
Establish the Efficacy Between the Four Schemes in Terms of the Aggressiveness of the Tumors According to the Gleason Classification, Establish the Efficacy Between the Four Schemes in Terms of Morbidity Associated With the Technique
Impact of Magnetic Resonance and Biomarkers for Screening for Prostate Cancer. Cost-effectiveness Analysis
Objectives: To establish if there are differences between an ultrasound-guided transrectal prostate biopsy (BPTE) and a transperineal prostatic biopsy (BPTP) with and without a multiparametric Magnetic Resonance (RMmp) in…
- Conditions
- Establish the Efficacy Between the Four Schemes in Terms of the Aggressiveness of the Tumors According to the Gleason Classification, Establish the Efficacy Between the Four Schemes in Terms of Morbidity Associated With the Technique, Establish the Efficacy Between the Four Schemes in Terms of the Patient's Subjective Perception Regarding Pain and Quality of Life, Establish the Association of the Tumor Biomarker in the Early Detection and Aggressiveness of Tumors
- Trial name
- RMPBX201801 (NCT04283032)
- Testing
- Multiparametric magnetic resonance
- Where
- Spain
- Volunteers
- 628 people
- Sponsor
- InvestigatorUrologyIBSAL
Physical Disability, Quality of Life
PLAY LONG: The Effect of Sports and Recreation Participation for Young chiLdren With physicAl disabilitY
Ten year longitudinal survey following children with disabilities who have participated in Sports and Recreation from a young age (5 to 10), and the parents of children who have participated in Sports and Recreation at a young…
- Conditions
- Physical Disability, Quality of Life, Social Interaction, Health, Subjective
- Trial name
- PLAY-LONG (NCT03256318)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Allina Health System
Contraceptive Usage, HIV Infections
Effect of Dolutegravir on Etonogestrel Levels in HIV-infected Women in Botswana
The primary aim is to assess if etonogestrel (ENG) implant users taking dolutegravir (DTG) have a 20% or greater change in their ENG plasma levels, compared to women taking no antiretroviral therapy (ART).
- Conditions
- Contraceptive Usage, HIV Infections, Drug Interaction
- Trial name
- NCT03336346
- Testing
- dolutegravir, ENG implant, Efavirenz
- Where
- Botswana
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Columbia University
Drug Interaction Study
To Evaluate the Effect of Clarithromycin on the Systemic Exposure of Pacritinib in Healthy Subjects
This will be an open-label, single-center, crossover, one-way, drug-interaction study to evaluate the effect of 500 mg clarithromycin BID (dosed to steady state) on the PK of a single 400-mg dose of pacritinib in healthy male and…
- Trial name
- NCT02807051
- Testing
- Pacritinib, Clarithromycin, Pacritinib and Clarithromycin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CTI BioPharma
Adult, Drug Interactions
Effect of Multiple Doses of Modafinil on the Pharmacokinetics of Single Dose Lorlatinib in Healthy Participants
The primary purpose of the study is to characterize the safety profile of lorlatinib in the presence of a moderate CYP3A4/5 inducer, modafinil.
- Conditions
- Adult, Drug Interactions, Healthy Volunteers, Humans
- Trial name
- NCT03961997
- Testing
- Lorlatinib 50 mg, Lorlatinib 75 mg, Lorlatinib 100 mg
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Drug-drug Interaction
A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
This study is being done to look at how tucatinib could affect the way other drugs work. This study will look at healthy volunteers and how tucatinib affects their liver enzymes.
- Trial name
- NCT03723395
- Testing
- tucatinib, itraconazole, rifampin
- Where
- 2 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Seagen Inc.
Diabetes Mellitus, Type 2, Erectile Dysfunction With Diabetes Mellitus
Evaluation of Drug Interactions of Saxagliptin With Sildenafil in Healthy Volunteers
Patients with diabetes are three times more likely to develop erectile dysfunction (ED), and longer duration of diabetes is strongly associated with ED.
- Conditions
- Diabetes Mellitus, Type 2, Erectile Dysfunction With Diabetes Mellitus, Drug Interaction
- Trial name
- NCT04170790
- Testing
- Saxagliptin 5mg, Sildenafil 50 mg
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Aging, Primary Hypothyroidism
Evaluation of Evening Versus Morning Levothyroxine Intake in Elderly
A study designed to compare evening versus morning levothyroxine intake in the elderly.
- Conditions
- Aging, Primary Hypothyroidism, Interaction Drug Food
- Trial name
- MONIALE (NCT03614988)
- Testing
- Evening Levothyroxine Administration, Morning Levothyroxine Administration
- Where
- Brazil
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cytochrome P450 Interaction
Study Evaluating the Effect of Multiple Doses of Itraconazole on the Drug Lu AF35700 in Healthy Young Men and Women
This study will investigate the effect of multiple doses of the strong P450 enzyme inhibitor itraconazole on the pharmacokinetics of Lu AF35700 in healthy subjects.
- Trial name
- NCT03103646
- Testing
- Lu AF35700, Itraconazole (200 mg), Itraconazole (300 mg)
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Adverse Drug Events, Adverse Drug Reactions
Pharmacogenetic Testing Among Home Health Patients
Patients meeting eligibility criteria will be randomized into two groups, one receiving pharmacogenetic testing and the other not receiving pharmacogenetic testing.
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- NCT02378220
- Testing
- Pharmacogenetic testing
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Genelex Corporation
Adverse Drug Interactions
Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions
Adverse drug-drug interactions (DDIs) are responsible for approximately 3% of all hospitalizations in the US, perhaps costing more than $1.3 billion per year.
- Trial name
- NCT00621309
- Testing
- Rifampicin, sulforaphane plus rifampicin, sulforaphane alone
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Washington