Clinical trials: Interaction
Mood Disorder, Substance-Related Disorders
Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)
The purpose of this study is to determinate the effect of a pre-treatment with the combined serotonin (5-HT) and norepinephrine (NE) transport blocker duloxetine on the pharmacodynamics and pharmacokinetics of…
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT00990067
- Testing
- 3,4-Methylenedioxymethamphetamine, Duloxetine
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarthritis
Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions(DDI) Among Osteoarthritis Patients
Using a retrospective database analysis, OA patients taking at least one CYP450-metabolized opioid (codeine, fentanyl, hydrocodone, methadone, oxycodone, or tramadol) and at least one other prescription drug metabolized via the…
- Trial name
- NCT01177267
- Volunteers
- 10,000 people
- Sponsor
- NEMA Research, Inc.
Cognitive Performance, Physical Performance Enhancement
Effects of Caffeine and L-Theanine on Physical and Cognitive Performance in Trained Athletes
The aim of this clinical trial is to examine how caffeine and L-theanine, taken alone or together, affect both physical and cognitive performance in healthy, trained athletes.
- Conditions
- Cognitive Performance, Physical Performance Enhancement, Caffeine and L-theanine Interaction
- Trial name
- NCT07268573
- Testing
- Caffeine, L-theanine, Combined Caffeine and L-Theanine
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ulaş Can YILDIRIM
Childhood Obesity
Healthy Kids I-PAL
Up to 30 parent/child dyads will be recruited to participate in an m-Health intervention (delivered over smartphone, iPad/Tablet, or desktop/laptop) to promote healthy behaviors and healthy weight among children and their parents.
- Trial name
- NCT03297541
- Testing
- m-health approach
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Endodontic Disease, Periodontitis
Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF
The endodontic periodontal-disease is characterized by the involvement of the pulp and periodontal disease in the same tooth. The anatomic connections between the dental pulp and the periodontium provide a pathway for perio-endo…
- Trial name
- NCT05681754
- Testing
- Experimental: RCT using hydraulic calcium silicate sealer and L-PRF + GTR, Experimental: RCT using conventional sealer and L-PRF + GTR, Experimental: RCT using hydraulic calcium silicate sealer and GTR
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- King's College London
Healthy Volunteers
Drug Interaction and Food Effect Study of CS0159
Purpose: This study aims to evaluate the effect of food (high-fat, high-calorie meal) on the pharmacokinetic (PK) profile of CS0159 tablets and to assess the drug-drug interactions (DDI) when CS0159 is co-administered with a…
- Trial name
- NCT07429331
- Testing
- CS0159 Tablet, Rifampicin Capsule, Itraconazole Capsule
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cascade Pharmaceuticals, Inc
Inactivity, Physical
Web-based Muscle-strengthening and Aerobic Physical Activity Intervention for Latinas
The disproportionately low physical activity (PA) in Latinas, particularly muscle-strengthening activities, and related chronic diseases (e.g., obesity, diabetes, cancer) signifies an urgent public health concern.
- Trial name
- NCT05613231
- Testing
- Aerobic plus muscle-strengthening physical activity intervention, Original physical activity intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brown University
Neoplasms
Effect of Regorafenib on Digoxin and Rosuvastatin in Patients With Advanced Solid Malignant Tumors.
Evaluate the effect of regorafenib on the pharmacokinetics of digoxin (P-gp substrate : P-glycoprotein) and rosuvastatin (BCRP substrate: Breast cancer resistant protein) by comparing their Area under time curve (AUC(0-24)) and…
- Trial name
- NCT02106845
- Testing
- Digoxin, Rosuvastatin, Regorafenib (Stivarga, BAY73-4506)
- Where
- 5 sites in Germany, Hungary
- Volunteers
- 42 people
- Sponsor
- Bayer
Obesity
Interdisciplinary Weight Loss Therapy Associate With the Use of Interactive Digital Technology
Obesity is a complex disease associate to metabolic alterations, which may lead to cardiometabolic risk in women with obesity. The use of interactive digital technology as adjuvante tool to the clinical practices in weight loss…
- Trial name
- NCT04034472
- Testing
- Interdisciplinary intervention in obesity
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of São Paulo
Food-drug Interaction
A Food Effect Study of 60mg ER Torsemide
This study will evaluate the effects of a high-fat meal (food effect) on the bioavailability and pharmacokinetics of 60mg ER Torsemide tablet after single dose oral administration in healthy volunteers.
- Trial name
- NCT03215875
- Testing
- Fed- 60mg ER Torsemide, Fasting- 60mg ER Torsemide
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Adverse Drug Events, Adverse Drug Reactions
Pharmacogenetic Testing Among Home Health Patients
Patients meeting eligibility criteria will be randomized into two groups, one receiving pharmacogenetic testing and the other not receiving pharmacogenetic testing.
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- NCT02378220
- Testing
- Pharmacogenetic testing
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Genelex Corporation
Cancer, Tobacco Dependence
Tobacco Cessation Care for Cancer Patients by Automated Interactive Outreach
This is a multi-arm, randomized controlled, pilot study which will recruit cancer patients who have been seen by a UCSF Cancer Center-affiliated clinical department to evaluate the efficacy of "CareConnect".
- Conditions
- Cancer, Tobacco Dependence, Tobacco Use Cessation
- Trial name
- NCT05829824
- Testing
- CareConnect, AutoReach, Biospecimen samples
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
Schizophrenia
Creating Live Interactions to Mitigate Barriers
This study is a validation study to evaluate the acceptability, feasibility and impact of a mobile psychosocial intervention to enhance social functioning in people with schizophrenia.
- Trial name
- CLIMB (NCT03317769)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Optimized social skills training
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Posit Science Corporation
Drug-drug Interaction
A Study of PBI-200 With Ritonavir or Cobicistat in Healthy Volunteers
This is a drug-drug interaction study in volunteers to evaluate the effect of ritonavir or cobicistat on the pharmacokinetics (PK) of PBI-200.
- Trial name
- NCT05692570
- Testing
- PBI-200 Tablet, Ritonavir Oral Tablet, Cobicistat Oral Tablet
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Pyramid Biosciences
Chronic Obstructive Pulmonary Disease, Asthma
Drug Interaction Study of Azithromycin and Theophylline
Macrolides are potent inhibitors of cytochrome P450 isoenzyme 3A4（CYP3A4）and thus interfere with the pharmacokinetics of many other drugs that are metabolised by this enzyme like theophylline.The aim of this study is to determine…
- Trial name
- NCT02023554
- Testing
- Theophylline with azithromycin, Theophylline alone
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhujiang Hospital
Diagnostic Imaging, Eye Tracking
AI Timing in Chest X-ray Interpretation Using Eye-Tracking
Chest X-rays are commonly used to help diagnose and manage chest conditions. Artificial intelligence (AI) tools are increasingly being used to support chest X-ray interpretation.
- Conditions
- Diagnostic Imaging, Eye Tracking, Artificial Intelligence (AI)
- Trial name
- CREAITED (NCT07675694)
- Testing
- Original CXR First Timing, AI Output First Timing
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Hypertension
A Clinical Trial to Evaluate Drug-drug Interactions and Safety Between "BR1015-1" and "BR1015-2" in Healthy Volunteers
The purpose of this study is to evaluate pharmacokinetic interactions (Drug-Drug interaction) and safety between "BR1015-1" and "BR1015-2" in healthy volunteers.
- Trial name
- NCT05097794
- Testing
- BR1015-1, BR1015-2, BR1015-1 + BR1015-2
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Anemia of End Stage Renal Disease
Prospective Observational Study of Erythropoietin-Iron Interaction in Anemia of Renal Disease
The purpose of this study is to prospectively collect data on doses of Erythropoietic Stimulating Agents (ESA) and Intravenous Iron, and the markers of erythropoietic activity and iron status.
- Trial name
- NCT01719146
- Testing
- Specimen collection
- Where
- 3 sites in United States
- Volunteers
- 134 people
- Sponsor
- University of Louisville
Drug-drug Interaction
Drug-drug Interactions Between DWC202211 and DWC202212 in Healthy Subjects
An open-label phase 1 study to evaluate pharmacokinetic/pharmacodynamic drug-drug interactions and safety/tolerability of DWC202211 and DWC202212 compared to coadministration in healthy
- Trial name
- DWJ1610 (NCT05699070)
- Testing
- DWC202211 100mg, DWC202212 5mg, DWC202211 100mg + DWC202212 5mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Non Small Cell Lung Cancer, Immunotherapy
Effect of G-CSF on MDSC and Cancer Stem-cells Interactions in Non-small Cell Lung Cancers (CIRCUIT)
Immunotherapy have revolutionized the field of oncology, but response rates are low and all patients relapse, due to immunologic (myeloid immunosuppressive cells) and non-immunologic (cancer stem- cells (CSC)) mechanisms.
- Conditions
- Non Small Cell Lung Cancer, Immunotherapy, Granulocyte Colony Stimulating Factor
- Trial name
- CIRCUIT (NCT06711770)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
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