Clinical trials: Interaction
Childhood Obesity
The Bottle Optimization Testing Tiny Little Eaters Study
The researchers will study how babies respond to bottle nipples with different flow rates over a few days, and how this may affect how much milk they drink, their feeding patterns, and their sleep.
- Trial name
- BOTTLE (NCT07665983)
- Testing
- Feeding
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Drug Interaction Potentiation, Healthy
Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor
This is a Phase 1, single-center, fixed-sequence, open label, drug-drug interaction study of the effect of multiple daily doses of oral itraconazole 200 mg, a strong inhibitor of CYP3A, given with mifepristone 900 mg QD, in…
- Trial name
- NCT03259542
- Testing
- Mifepristone 300 MG, Itraconazole 100 MG
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Comparison of Availability for Prediction of Volume Responsiveness, Comparison of Limits of Agreement for Invasive and Non-invasive Measurement of Stroke Volume Variation
Non-invasive Measurement of Central Hemodynamics by Electrical Impedance Tomography
The purpose of this study is to evaluate the ability to measure central hemodynamics and heart-lung interactions non-invasively by electrical impedance tomography and compare it to clinically established hemodynamic monitoring.
- Trial name
- NCT01412970
- Testing
- volume loading
- Where
- Germany
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Work of Breathing
The Role of Environmental Temperatures in Respiratory Control
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing…
- Trial name
- NCT07470086
- Testing
- Thermoneutral temperature environment, Cold temperature environment, Hot temperature environment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gut Inflammation, Hypertension
Gut Organoid and Microbiome Interactions in Hypertension
The study compared basic properties of gut epithelia of hypertensive and normotensive reference subjects. The study determined if there are fundamental differences in the gut epithelium in hypertension compared to normotension.
- Trial name
- NCT04497727
- Testing
- Gene Expression
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Florida
Drug Interaction Study
Rivaroxaban Hypericum Trial
Single-center, open-label, sequential treatment study to investigate the influence of the combined P-glycoprotein and CYP3A4 inducer hypericum perforatum on the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy…
- Trial name
- NCT03796377
- Testing
- St Johns Wort Extract, Rivaroxaban
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Perceived Stress, Positive and Negative Affect
Efficacy of Interactive Audio-based Mindfulness ChatGPT-Powered Intervention on Well-being
Brief mindfulness intervention is a short form is a form of short-duration practice, typically delivered for around 30 minutes or less (Howarth et al., 2019).
- Conditions
- Perceived Stress, Positive and Negative Affect, State Anxiety, Self Control
- Trial name
- NCT07333365
- Testing
- Interactive Mindfulness Breathing ChatGPT-Powered Intervention, Interactive Mind Wandering ChatGPT-Powered Intervention, Mindfulness Breathing Audio-only
- Where
- Singapore
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Singapore Management University
Colon Cancer
Interactive Cancer Communication System (ICCS) Directed Physical Activity Enhancement for Colon Cancer Survivors
This study will develop and test the benefits of a new ICCS (Interactive Cancer Communication System), a mobile Comprehensive Health Enhancement Support System (Survivorship CHESS) in colon cancer survivors.
- Trial name
- NCT01133132
- Testing
- Survivorship CHESS, Control
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Wisconsin, Madison
Healthy
Drug-drug Interaction Trial of BI 113608 in Combination With Ketoconazole and Voriconazole in Healthy Male Subjects
The primary objective of this trial is to investigate the relative bioavailability of a single oral dose of BI 113608 without and with ketoconazole and voriconazole at steady state.
- Trial name
- NCT01787032
- Testing
- BI 113608, Ketoconazole, Voriconazole
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
The purpose of this study is to determine the effect of quinidine on the levels of orforglipron in the blood stream and how long it takes the body to eliminate it, when administered orally in healthy participants.
- Trial name
- NCT06704763
- Testing
- Orforglipron, Midazolam, Quinidine
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
SARS-CoV-2 Infection, Hematologic Malignancy
Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors
The goal of this observational study is to compare the immune function and infection mechanism of patients with hematologic tumors and those people without underlying diseases after infection with SARS-CoV-2.
- Trial name
- NCT05683353
- Testing
- None intervention
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Healthy
Evaluation of PK and Safety of D-0120 and Allopurinol
Evaluation of safety and PK interaction between D-0120 and Alopurinol in healthy adult subjects
- Trial name
- NCT05360628
- Testing
- D-0120 in combination with Allopurinol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- InventisBio Co., Ltd
Nurse, Chatbot
Exploring the Effectiveness of Multimodal Interactive Chatbot-Assisted Learning on Nursing Documentation Competence Among Novice Nurses
This study aims to investigate the effects of using a chatbot as a supplementary learning tool on the nursing documentation competence of novice nurses.
- Conditions
- Nurse, Chatbot, Education Nursing
- Trial name
- NCT07736898
- Testing
- Chatbot
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Volunteers
Drug Drug Interaction (DDI) Between Supaglutide and Digoxin or Metformin
This is a study of a drug drug interaction between Supaglutide and Digoxin or Metformin.
- Trial name
- NCT05694221
- Testing
- Supaglutide injection, Digoxin, Metformin
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Shanghai Yinnuo Pharmaceutical Technology Co., Ltd.
Drug Drug Interaction
Givinostat and Metabolites Pharmacokinetics in Urine and Plasma (Part 3)
Primary objective: To evaluate the plasma and urine PK of Givinostat following multiple oral doses of Givinostat. Secondary objective: To assess the safety and tolerability multiple oral doses of Givinostat.
- Trial name
- NCT05860114
- Testing
- Givinostat
- Where
- Portugal
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Italfarmaco
Healthy Volunteers
Study to Evaluate the Effect of Repeat-Dose Rifampin on the Pharmacokinetics (PK) of PF-06651600
Study to Evaluate the Effect of Repeat-Dose Rifampin on the pharmacokinetics (PK) of PF-06651600.
- Trial name
- NCT04266509
- Testing
- PF-06651600, Rifampin
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity
Glucose, Brain and Microbiota
The accumulation of iron is known to affect the functions of the liver, adipose tissue and muscle. The brain is a well-known place of iron deposition, which is associated with cognitive parameters of subjects with obesity.
- Trial name
- IRONMET+CGM (NCT03889132)
- Testing
- Bariatric Surgery
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Type 2 Diabetes Mellitus
A Study to Evaluate the Interaction of LX4211 and Metformin in Healthy Subjects
The purpose of this study is to determine the effects of LX4211 and metformin on each other when given at the same time as single doses to healthy human subjects.
- Trial name
- NCT01292993
- Testing
- 400 mg LX4211, 1000 mg metformin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Healthy Participants
A Study to Explore Pharmacokinetic Interaction Between Rilpivirine and Metformin in Healthy Participants
The purpose of the study is to evaluate the effect of steady-state (constant concentration of medication in the blood) rilpivirine on pharmacokinetics (how a single dose of metformin is absorbed in the body, distributed within…
- Trial name
- NCT01719614
- Testing
- Metformin, Rilpivirine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Janssen R&D Ireland
Healthy
CRF - Nociceptin Receptor Interactions
To determine if [C-11]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions
- Trial name
- NCT03302416
- Testing
- Hydrocortisone, [C-11]NOP-1A
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
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