Clinical trials: Intermediate Age-Related Macular Degeneration
Retinal Detachment, Macular Edema
OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal
Silicone oil is commonly used as a temporary intraocular tamponade to support the retina during vitreoretinal surgery for complex retinal detachment and other severe retinal conditions.
- Conditions
- Retinal Detachment, Macular Edema, Silicone Oil Tamponade, Epiretinal Membrane
- Trial name
- NCT07865468
- Volunteers
- 30 people
- Sponsor
- Assiut University
Age - Related Macular Degeneration (AMD)
Enhanced Vision and Imaging Tests for Enabling Treatment Trials in Early and Intermediate AMD
This monocentric prospective longitudinal observational study will validate fundus-tracked dark adaptometry as an endpoint for future treatment trials in early and intermediate age-related macular degeneration (AMD).
- Trial name
- EVITE-AMD (NCT07515521)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maximilian Pfau
Age Related Macular Degeneration, Intermediate AMD
A Collaborative Resource of Heidelberg Multimodal Imaging of Intermediate and Early Atrophic AMD Cases to Study Prediction of Disease Progression
This is a multicentre retrospective and prospective cohort study with the goal to develop a well-characterised multimodal image database of eyes with intermediate AMD with and without early atrophy. The main objectives are: 1.
- Conditions
- Age Related Macular Degeneration, Intermediate AMD, Atrophy, Prediction
- Trial name
- INTERCEPT-AMD (NCT05698316)
- Testing
- Collection of both retrospective and prospective data collection in 3 visits.
- Where
- 25 sites in France, Germany and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Non-infectious Intermediate and Posterior Uveitis
Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate
BACKGROUND: Uveitis comprises of a group of diseases associated with inflammation of the eye that can lead to vision loss. Some people with uveitis also have macular edema (swelling of the retina at the back of the eye).
- Trial name
- MEXX (NCT01314417)
- Testing
- Methotrexate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Eye Institute (NEI)
Age Related Macular Degeneration (AMD), Age Related Macular Degeneration
Evaluating the Relationship Between Function and Structure Using Data From a GA Natural History Cohort
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration that leads to progressive and irreversible vision loss.
- Conditions
- Age Related Macular Degeneration (AMD), Age Related Macular Degeneration, AMD, Geographic Atrophy
- Trial name
- ARCHERY (NCT07424235)
- Volunteers
- 60 people
- Sponsor
- IRCCS Ospedale San Raffaele
Age-Related Macular Degeneration
Subthreshold Laser Treatment in Intermediate Age-related Macular Degeneration With Nascent Geographic Atrophy Study
This study is a prospective, single centre, randomized, sham-controlled, double-masked, clinical trial which aims to investigate the effect of subthreshold nanosecond laser on disease progression in eyes with intermediate…
- Trial name
- LIANA (NCT05200624)
- Testing
- 2RT subthreshold nanosecond laser
- Where
- 4 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Center for Eye Research Australia
Age Related Macular Degeneration
Usage of the Home Macular Perimeter (HMP)
Demonstrate the ability of the current interactive tutorial and 1-800 support to teach an AMD patient to use the HMP device.
- Trial name
- HMP (NCT00596388)
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Notal Vision Ltd.
Macular Edema, Cystoid, Uveitis
Vascular Endothelial Growth Factor (VEGF) in Uveitis
This study will look for the presence in blood of a substance called vascular endothelial growth factor (VEGF) in patients with uveitis (eye inflammation).
- Trial name
- NCT00001738
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Age Related Macular Degeneration
Association of MPOD Values With Blue Light.
This study aims to investigate in healthy adults 18-65 years of age the association of electronic device blue light exposure and macular pigment optical density (MPOD) considering usual dietary intake of lutein and zeaxanthin…
- Trial name
- AMPBL19 (NCT04779398)
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Age-related Macular Degeneration
Tools to Optimize Patient Presentation After Onset of Exudative Age-Related Macular Degeneration (AMD)
Exudative age-related macular degeneration ("wet" AMD) continues to be a leading cause of central vision loss in the US for those over fifty years of age, despite the availability of several effective interventions to contain…
- Trial name
- NCT01337414
- Testing
- VMS diary booklet, Standard of Care
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Johns Hopkins University
Macular Degeneration, Senile, Laser Burn of Retina
Subthreshold Laser Treatment for Reticular Pseudodrusen Secondary to Age-related Macular Degeneration
Prospective, randomized, controlled, longitudinal, interventional multicentric study involving patients with reticular pseudodrusen secondary to AMD.
- Conditions
- Macular Degeneration, Senile, Laser Burn of Retina, Macular Degeneration Intermediate, Macular Degeneration, Dry
- Trial name
- PASCAL-RPD (NCT04847635)
- Testing
- Pascal Synthesis 577 sub-threshold laser (Topcon Corporation, Tokyo, Japan)
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale San Raffaele
Macular Edema, Radiation Retinopathy
Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
This phase I trial will assess primarily the safety and secondarily anti-inflammatory effect of Episcleral Dexamethasone in patients suffering from macular edema and other disorders of the retina, choroid and vitreous.
- Conditions
- Macular Edema, Radiation Retinopathy, Branch Retinal Vein Occlusion, Epiretinal Membrane
- Trial name
- NCT04120311
- Testing
- Episcleral Dexamethasone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Targeted Therapy Technologies, LLC
Age-related Macular Degeneration
Comparison of Safety, Effectiveness and Quality of Life Outcomes Between Labeled Versus "Treat and Extend" Regimen in Turkish Patients With Choroidal Neovascularisation Due to Age-related Macular Degeneration (AMD)
The purpose of the study was to compare 2 treatment regimens for patients suffering from choroidal neovascularisation secondary to age-related macular degeneration (AMD).
- Trial name
- SALUTE (NCT01148511)
- Testing
- Ranibizumab 0.5 mg
- Where
- 8 sites in Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Novartis Pharmaceuticals
AMD, Soft Drusen
Study to Evaluate the Response to Supplementation With Postbiotics in Patients With Macular Degeneration.
A pilot study to establish the efficacy and safety of supplementation with postbiotics in patients with macular degeneration.
- Conditions
- AMD, Soft Drusen, Reticular Pseudodrusen, Drusen Stage Macular Degeneration
- Trial name
- REVERS (NCT05056025)
- Testing
- Postbotics and Vitamins, Vitamins
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Institut de la Macula y la Retina
Age Related Macular Degeneration
Correlation Between Visual Field Defects on Foresee Preferential Hyperacuity Perimeter(PHP) and on Optical Coherence Tomography (OCT) in Patients With Choroidal Neovascularization (CNV)
Study come to investigate the correlation between visual fields (VF) defects map generated by preferential hyperacuity perimeter (PHP) and features of the choroidal neovascular lesions (CNV) demonstrated by Optical Coherence…
- Trial name
- PHP (NCT00692887)
- Testing
- PHP - Preferential Hyperacuity Perimeter (Foresee)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Notal Vision Ltd.
Lupus Erythematosus, Lupus Erythematosus, Systemic
Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)
The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients.
- Conditions
- Lupus Erythematosus, Lupus Erythematosus, Systemic, Age Related Macular Degeneration
- Trial name
- PL-AMD (NCT03504540)
- Testing
- Blood test
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Macular Degeneration
Correlation Between Visual Acuity Measurements, Quality of Life and Morphological Parameters in Wet AMD Patients
Patient-reported vision-related quality of life (QOL) outcomes are increasingly incorporated into clinical trials of new treatments for age-related macular degeneration (AMD).
- Trial name
- COSP (NCT03438669)
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 53 people
- Sponsor
- Dr. med. Katja Hatz
Intermediate Age-Related Macular Degeneration
QA108 Phase III Study in Subjects With Intermediate AMD
This is a phase III randomized, double-masked, placebo-controlled, multicenter study. To evaluate the efficacy and safety of QA108 granules in the treatment of intermediate age-related macular degeneration.
- Trial name
- NCT07189169
- Testing
- QA108 granules
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Smilebiotek Zhuhai Limited
Age Related Macular Degeneration
Correlation Between Visual Field Defects on FORESEE HOME and on Optical Coherence Tomography in Choroidal Neovascularization Subjects
The FORESEE HOME is used in the recent years to detect Age-related Macular Degeneration (AMD) lesions. The device is capable of differentiation as to stages of AMD and early detection of changes including choroidal…
- Trial name
- NCT00884637
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Notal Vision Ltd.
Age Related Macular Degeneration
Usability of the Foresee Home in Intermediate Age Related Macular Degeneration (AMD) Patients
The study purpose is to demonstrate that the target population can receive a packed FORESEE HOME unpack it, install and operate it to an extent that the FORESEE HOME can monitor them for changes in the visual field with good…
- Trial name
- UU2 (NCT00748384)
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Notal Vision Ltd.