Clinical trials: Intermediate Coronary Lesions
Depression, Major Depressive Disorder
Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD.
- Conditions
- Depression, Major Depressive Disorder, Cardiovascular Disease, Coronary Artery Disease
- Trial name
- NCT00818506
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Coronary Artery Disease Left Main
Imaging and Physiology for Intermediate Left Main Stem Stenosis
The present research aims to determine the impact of stenoses in downstream vessels on the FFR and iFR measurements of left main coronary artery (LMCA) stenoses of intermediate severity as determined by coronary angiography.
- Trial name
- VIP-LMS (NCT04531007)
- Testing
- iFR/ FFR/ IVUS/ OCT
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Coronary Atherosclerotic Disease, Coronary Occlusive Diseases
COMPETE: A Clinical Evaluation of Chrono Carbostent Carbofilm™ Coated Stent
The COMPETE study is a prospective,randomized,two-arm multi-center clinical trial comparing two commercially available coronary stents: Chrono Carbostent Carbofilm™ Coated vs Driver/Micro-Driver Coronary Stent System.
- Conditions
- Coronary Atherosclerotic Disease, Coronary Occlusive Diseases, Coronary Artery Diseases, Myocardial Ischemia
- Trial name
- COMPETE (NCT00920283)
- Testing
- Chrono Carbostent Carbofilm™ Coated Coronary Stent, Driver Cobalt Alloy Coronary Stent
- Where
- 6 sites in Italy
- Volunteers
- 205 people
- Sponsor
- CID - Carbostent & Implantable Devices
Coronary Artery Disease
Vascular Evaluation for Revascularization: Defining the Indications for Coronary Therapy: A Pilot Study
The present prospective, multicenter study will therefore be performed with the primary objective of establishing the correlation between fractional flow reserve (FFR) and intravascular ultrasound with virtual histology…
- Trial name
- VERDICT (NCT01158053)
- Testing
- FFR and VH-IVUS, IVUS and FFR
- Volunteers
- 291 people
- Sponsor
- Volcano Corporation
True Coronary Bifurcation Lesions
COmplex BifuRcation Lesions: a Comparison Between the AXXESS Device and Culotte Stenting: an Optical Coherence Tomography (OCT) Study
Treatment of bifurcation lesions with drug-eluting stents (DES) (especially when a double stent technique is used) is associated with a higher risk for stent thrombosis.
- Trial name
- COBRA (NCT01486095)
- Testing
- AXXESS + Biomatrix Biolimus Eluting stent, Culotte technique with Xience V or Xience Prime stents
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ischemic Cardiovascular Disease
Multicenter Randomised Prospective Study for External Support Mesh VEST of Venous Coronary Grafts on the Right Territory
Multicentre randomised prospective study aimed at verifying medium-term patency of venous grafts on the right coronary artery territory, by clinical and/or instrumental follow-up with particular attention to clinically driven…
- Trial name
- RiVEST (NCT06877195)
- Testing
- CABG
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Cardiochirurgia E.H.
Coronary Artery Disease
China Made Sirolimus Eluting Stent for Intermediate Lesion
Sirolimus-eluting stent (SES) has been proven to improve outcomes in patients with significant coronary artery diseae(> 70% lumen diameter narrowing).
- Trial name
- SESIL (NCT01375296)
- Testing
- China-made SES (Firebird 2 and Excel), routine medicine
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Myocardial Ischemia
Multimodality Investigation of Intermediate Culprit Lesion With Negative FFR in NSTE-ACS
Ten-fifteen percent of acute coronary syndromes without ST-segment elevation (NSTE-ACS) are caused by intermediate lesions without signs of unstable plaque.
- Trial name
- SHERLOCK (NCT03205514)
- Testing
- NSTE-ACS with intermediate stenosis and negative FFR
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
Percutaneous Coronary Intervention
The Safety and Efficacy of DIOR Balloon in Coronary Bifurcation Lesions
To evaluate the safety and effectiveness of paclitaxel-eluting coronary artery balloon dilation catheter (DIOR) in revascularization of coronary bifurcation lesions compared with paclitaxel-eluting balloon (Bingo), and to provide…
- Trial name
- BEYOND-II (NCT03820622)
- Testing
- Paclitaxel-Eluting Coronary Balloon Dilation Catheter (DIOR), Paclitaxel-Eluting Balloon (Bingo)
- Where
- 13 sites in China
- Volunteers
- 220 people
- Sponsor
- CCRF Inc., Beijing, China
Stable Angina, Unstable Angina
International Randomized Comparison Between DES Limus Carbostent and Taxus DES in the Treatment of De-novo Coronary Lesions
The purpose of this study is to demonstrate non-inferiority in terms of safety and efficacy of DES Limus Carbostent compared to the Taxus Liberté in treating de-novo atherosclerotic lesions in native coronary arteries.
- Conditions
- Stable Angina, Unstable Angina, Documented Silent Ischemia
- Trial name
- NEXT (NCT01373502)
- Testing
- DES Limus Carbostent, Taxus Liberté Stent
- Where
- 11 sites in Belgium, France and 2 more
- Volunteers
- 323 people
- Sponsor
- CID - Carbostent & Implantable Devices
Coronary Artery Disease
A Randomized Comparison of Clinical Outcomes Between Everolimus-eluting Bioresorbable Vascular Scaffold Versus Everolimus-eluting Metallic Stent in Long Coronary Lesions
PCI of diffuse long coronary lesions still remains challenging because of relatively high risk of in-stent restenosis and stent thrombosis compared to short coronary lesions.
- Trial name
- NCT02796157
- Testing
- PCI with Absorb everolimus-eluting bioresorbable vascular scaffold, PCI with Xience everolimus-eluting metallic stent
- Where
- South Korea
- Volunteers
- 950 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization
The FAST III is a randomized controlled, open-label, multicenter, international, non-inferiority, strategy trial. A total of 2228 participants will be randomized in a 1:1 fashion to either vFFR- or FFR guided revascularization.
- Trial name
- FAST III (NCT04931771)
- Testing
- vFFR guided revascularization, FFR guided revascularization
- Where
- 40 sites in France, Germany and 5 more
- Volunteers
- 2,235 people
- Sponsor
- ECRI bv
Compare Image Quality Between SDCT and Conventional CT Images of Any Tissue Lesion, Determine Optimal Monochromatic Energy Level for a Coronary Artery Image
Preliminary Assessment of Added Diagnostic Value of Dual Energy CT Images Using Data Acquired on a Spectral Detector CT
Study hypothesis: Post-processed SDCT images provide additional diagnostic value over conventional CT datasets. The CT examination would be a clinically-necessary, standard-of-care CT performed as per the clinical indication.
- Trial name
- NCT02760706
- Testing
- Computed Tomography scan
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Philips Healthcare
ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients
This prospective multicenter observational cohort study is designed to study the diagnostic performance of acute-setting angiography-based FFR (e.g.
- Conditions
- ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05698719
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 111 people
- Sponsor
- Erasmus Medical Center
Coronary Artery Stenosis
Fractional Flow Reserve and Intravascular Ultrasound in Evaluating Intermediate Coronary Lesions
Recent studies have shown that optimal IVUS criteria defining the functional significance (FFR < 0.8) of intermediate coronary stenoses is different according to their locations of the coronary tree.
- Trial name
- NCT01414361
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Myocardial Ischemia
The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes
The present study evaluates skin microvascular reactivity and coronary physiology in the same coronary artery disease (CAD) patients.
- Trial name
- NCT05864729
- Testing
- Coronary angiography with physiological lesion assessment by fractional flow reserve (FFR) and contrast fractional flow reserve (cFFR).
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Stroke, Atrial Fibrillation
The Incidence of New-brain Lesions on Brain MRI and Safety Between Edoxaban and Apixaban in Patients with Stroke and Nonvalvular Atrial Fibrillation
This study aims to determine whether there is a difference in brain lesion occurrence and safety when brain MRI is followed up between edoxaban and apixaban in stroke patients with nonvalvular atrial fibrillation through…
- Trial name
- APIXABAN (NCT06864052)
- Testing
- Administration of Apixaban, Administration of Edoxaban
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Ewha Womans University Seoul Hospital
Ischemic Heart Disease, Angina, Stable
Post-Revascularization Optimization and PHysiological Evaluation of intermediaTe Lesions
PROPHET-FFR is a single center ambispective registry aiming to explore the impact of post-revascularization functional assessment on later outcomes.
- Conditions
- Ischemic Heart Disease, Angina, Stable, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- PROPHET-FFR (NCT05056662)
- Testing
- Invasive functional evaluation with either Pd/Pa, FFR, iFR or contrast FFR
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Catholic University of the Sacred Heart
Aortic Stenosis
OpSens PRIME CLASS
In this study it is aimed to determine the diagnostic value of physiological measurements in the presence of aortic stenosis, and whether these are more accurate than angiographic assessment.
- Trial name
- NCT05070130
- Testing
- dPR and FFR
- Where
- 5 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Opsens, Inc.
Coronary Atheroscleroses, Coronary Angiography
Risk Factors of Intermediate Coronary Lesion Progression
Coronary intermediate lesions generally refer to lumen narrowing with diameter stenosis% (DS%) between 50% and 70% on angiography.
- Trial name
- NCT03855436
- Where
- China
- Volunteers
- 1,389 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases