Clinical trials: Intermediate Coronary Lesions
Myocardial Ischemia
The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes
The present study evaluates skin microvascular reactivity and coronary physiology in the same coronary artery disease (CAD) patients.
- Trial name
- NCT05864729
- Testing
- Coronary angiography with physiological lesion assessment by fractional flow reserve (FFR) and contrast fractional flow reserve (cFFR).
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Atrial Fibrillation, Ischemic Stroke
Clinical Implication of Atrial Fibrillation Detection Using Wearable Device in Patients With Cryptogenic Stroke
Atrial fibrillation (AF) detected after ischemic stroke has immediate therapeutic implications, because it prompts a switch from antiplatelet to anticoagulant therapy.
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Transient Ischemic Attack
- Trial name
- CANDLE-AF (NCT04624646)
- Testing
- Ambulatory Holter monitoring, Discontinuous monitoring, Continuous single-lead ECG Patch
- Where
- 7 sites in South Korea
- Volunteers
- 338 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Coronary Angiography, Drug-eluting Stents
Proper Fractional Flow Reserve Criteria for Intermediate Lesions in the Era of Drug-eluting Stent
Angiographic evaluation for intermediate lesions is not always accurate. Fractional flow reserve-guided deferral strategy for these lesions showed the same event rate as routine intervention strategy.
- Conditions
- Coronary Angiography, Drug-eluting Stents, Fractional Flow Reserve, Myocardial
- Trial name
- DEFER-DES (NCT00592228)
- Testing
- Cypher, Taxus or Endeavor
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Seoul National University Hospital
Multi-vessel Diseases, Angina
Serial EValuation of multiplE Coronary Artery Diseases by an Optical Coherence Tomography; Assessment of the Changes of de Novo Lesions and Comparisons of Neointimal Coverage Between Xience Prime® Versus Cypher SelectTM Stents; SEVEN-Xience Study
This study is a prospective open-labeled, randomized study to compare the neointimal coverage at 3 months and 12 months and its serial changes between 3 months and 12 months according to the implanted DES and evaluate the serial…
- Trial name
- NCT01856374
- Testing
- Sirolimus-eluting stent (Cypher SelectTM, Cordis, Miami, FL), Everolimus-eluting stent(Xience Prime®, Abbott Vascular, Santa Claea, CA), Pravastatin 20mg
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Coronary Artery Stenosis
Fractional Flow Reserve (FFR) Versus Intravascular Ultrasound (IVUS) in Intermediate Coronary Artery Disease
This study is a prospective, randomized, multi-center, open label trial to compare the clinical outcomes and effectiveness of Intravascular ultrasound (IVUS) versus Fractional Flow Reserve (FFR) guided Percutaneous coronary…
- Trial name
- FAVOR (NCT01175863)
- Testing
- Grey scale intravascular ultrasound (Galaxy or Virtual histology-Intravascular Ultrasound), Pressure wire(Radi Medical Systems)
- Where
- 8 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Ajou University School of Medicine
Stroke, Atrial Fibrillation
The Incidence of New-brain Lesions on Brain MRI and Safety Between Edoxaban and Apixaban in Patients with Stroke and Nonvalvular Atrial Fibrillation
This study aims to determine whether there is a difference in brain lesion occurrence and safety when brain MRI is followed up between edoxaban and apixaban in stroke patients with nonvalvular atrial fibrillation through…
- Trial name
- APIXABAN (NCT06864052)
- Testing
- Administration of Apixaban, Administration of Edoxaban
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Ewha Womans University Seoul Hospital
Coronary Artery Disease
Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. But patients may have more than one narrowing and studies have shown that not all narrowings need to be treated.
- Trial name
- DEFINE-FLAIR (NCT02053038)
- Testing
- iFR, FFR
- Where
- 50 sites in United States, Australia and 15 more
- Volunteers
- 2,500 people
- Sponsor
- Imperial College London
Percutaneous Coronary Intervention
The Safety and Efficacy of DIOR Balloon in Coronary Bifurcation Lesions
To evaluate the safety and effectiveness of paclitaxel-eluting coronary artery balloon dilation catheter (DIOR) in revascularization of coronary bifurcation lesions compared with paclitaxel-eluting balloon (Bingo), and to provide…
- Trial name
- BEYOND-II (NCT03820622)
- Testing
- Paclitaxel-Eluting Coronary Balloon Dilation Catheter (DIOR), Paclitaxel-Eluting Balloon (Bingo)
- Where
- 13 sites in China
- Volunteers
- 220 people
- Sponsor
- CCRF Inc., Beijing, China
Coronary Artery Stenosis
COmplex BifuRcation Lesions: A Comparison Between the AXXESS Device and Culotte Stenting: An Optical Coherence Tomography (OCT) Study
The aim of this study is to compare vessel healing at 9 months using OCT imaging for two different treatment techniques for treating bifurcation lesions.
- Trial name
- COBRA (NCT00895791)
- Testing
- AXXESS Biolimus A9-eluting bifurcation stent, culotte stenting (Xience V)
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stable Angina, Acute Coronary Syndrome
Relationship Between Fractional Flow Reserve/ Instantaneous Wave Free Ratio and Endothelial Wall Shear Stress
This study, designed as a retrospective registry, aims to investigate the relationship and potential interplay between fractional flow reserve (FFR) or instantaneous waves free ratio (iFR) with wall shear stress (WSS) in the…
- Conditions
- Stable Angina, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- RELATE (NCT04048005)
- Testing
- Fractional flow reserve
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Stable Angina, Unstable Angina
International Randomized Comparison Between DES Limus Carbostent and Taxus DES in the Treatment of De-novo Coronary Lesions
The purpose of this study is to demonstrate non-inferiority in terms of safety and efficacy of DES Limus Carbostent compared to the Taxus Liberté in treating de-novo atherosclerotic lesions in native coronary arteries.
- Conditions
- Stable Angina, Unstable Angina, Documented Silent Ischemia
- Trial name
- NEXT (NCT01373502)
- Testing
- DES Limus Carbostent, Taxus Liberté Stent
- Where
- 11 sites in Belgium, France and 2 more
- Volunteers
- 323 people
- Sponsor
- CID - Carbostent & Implantable Devices
Coronary Artery Disease
Comparison Between Provisional Versus Routine Kissing Balloon Technique After Main Vessel Crossover Stenting for Bifurcated Lesions.
In the setting of single stent strategy for treatment of bifurcation, we investigate to compare simple strategy as "provisional final kissing balloon technique(fKBT)" to complex one as "routine FKBT", focusing on actual…
- Trial name
- PROTECT-SB (NCT01238510)
- Testing
- stent technique: Provisional fKBT, stent technique: Routine fKBT
- Where
- 2 sites in Japan
- Volunteers
- 120 people
- Sponsor
- Saiseikai Yokohama City Eastern Hospital
Coronary Artery Disease
COmplex Bifurcation PCI: AXXESS Device + Absorb BVS, vs Modified T Stenting With Absorb BVS
Comparison of healing responses after treatment of complex bifurcation lesions with a dedicated bifurcation device (Axxess™ Biolimus Eluting Coronary Bifurcation Stent System + Absorb BVS in the distal branches) versus the…
- Trial name
- COBRAII (NCT02628288)
- Testing
- Coronary Bifurcation PCI
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Atherosclerotic Disease, Coronary Occlusive Diseases
COMPETE: A Clinical Evaluation of Chrono Carbostent Carbofilm™ Coated Stent
The COMPETE study is a prospective,randomized,two-arm multi-center clinical trial comparing two commercially available coronary stents: Chrono Carbostent Carbofilm™ Coated vs Driver/Micro-Driver Coronary Stent System.
- Conditions
- Coronary Atherosclerotic Disease, Coronary Occlusive Diseases, Coronary Artery Diseases, Myocardial Ischemia
- Trial name
- COMPETE (NCT00920283)
- Testing
- Chrono Carbostent Carbofilm™ Coated Coronary Stent, Driver Cobalt Alloy Coronary Stent
- Where
- 6 sites in Italy
- Volunteers
- 205 people
- Sponsor
- CID - Carbostent & Implantable Devices
Coronary Artery Disease
Vascular Evaluation for Revascularization: Defining the Indications for Coronary Therapy: A Pilot Study
The present prospective, multicenter study will therefore be performed with the primary objective of establishing the correlation between fractional flow reserve (FFR) and intravascular ultrasound with virtual histology…
- Trial name
- VERDICT (NCT01158053)
- Testing
- FFR and VH-IVUS, IVUS and FFR
- Volunteers
- 291 people
- Sponsor
- Volcano Corporation
Coronary Artery Disease
Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization
The FAST III is a randomized controlled, open-label, multicenter, international, non-inferiority, strategy trial. A total of 2228 participants will be randomized in a 1:1 fashion to either vFFR- or FFR guided revascularization.
- Trial name
- FAST III (NCT04931771)
- Testing
- vFFR guided revascularization, FFR guided revascularization
- Where
- 40 sites in France, Germany and 5 more
- Volunteers
- 2,235 people
- Sponsor
- ECRI bv
Coronary Artery Disease, Coronary Disease
Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria at OCT in Patients With ACS
The INTERCLIMA (Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria Identified by Optical Coherence Tomography in Patients With Acute Coronary Syndrome) is a multi-center, prospective, randomized…
- Conditions
- Coronary Artery Disease, Coronary Disease, Ischemic Heart Disease
- Trial name
- INTERCLIMA (NCT05027984)
- Testing
- Optical coherence tomography, iFR/FFR/RFR
- Where
- 34 sites in Greece, Italy and 2 more
- Volunteers
- 1,425 people
- Sponsor
- Centro per la Lotta Contro l'Infarto - Fondazione Onlus
ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients
This prospective multicenter observational cohort study is designed to study the diagnostic performance of acute-setting angiography-based FFR (e.g.
- Conditions
- ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05698719
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 111 people
- Sponsor
- Erasmus Medical Center
Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions
A Trial in Stable Intermediate Coronary Lesions and Grey-zone FFR Values
In this randomised controlled trial of patients with stable angina and documented intermediate coronary disease with indeterminate or "grey-zone" Fractional Flow Reserve (FFR) we will randomise patients to either optimal medical…
- Conditions
- Grey-zone Fractional Flow Reserve, Intermediate Coronary Lesions, Stable Angina, Coronary Physiology
- Trial name
- GzFFR (NCT02425969)
- Testing
- PCI, Optimal Medical Therapy
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Golden Jubilee National Hospital
Coronary Artery Obstructive Disease, Chronic Total Occlusion Lesions
Role of CT Scan for the Successful Recanalization of Chronic Total Occlusion; a Randomized Comparison Between 3D CT-guided PCI vs. Conventional Treatment (CT-CTO Trial)
The revascularization of chronic total occlusion of coronary arteries (CTO) is the most challenging procedure for the coronary intervention.
- Trial name
- NCT02037698
- Testing
- Pre-PCI coronary CT scan
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Yonsei University