Clinical trials: Intermittent Hypoxia
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment
This study is testing a new treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and long-term symptoms after COVID-19.
- Trial name
- REenergizeME (NCT07317401)
- Testing
- Intermittent hypoxia-hyperoxia treatment (IHHT)
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypoxemia
Influence of Intermittent Hypoxia on Glycemic Control
The aim of this research project is to determine the effect of intermittent hypoxia on glucose uptake in response to an oral glucose tolerance test in healthy individuals, individuals with prediabetes and patients with type 2…
- Trial name
- NCT06490900
- Testing
- Intermittent hypoxia, Intermittent normoxia
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Obesity
Effects of High-intensity Exercise With Hypoxia and Taurine Supplementation on Metabolic and Mitochondrial Parameters
The prevalence of obesity in Brazil is one of the highest in Latin America. As an inflammatory disease, obesity needs to be treated, and one of the best interventions is exercise.
- Trial name
- NCT06579508
- Testing
- Cycle ergometer
- Where
- 2 sites in Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypoxic Breathwork With Music and Affirmative Messaging, Hypoxic Breathwork Only
Effects of Hypoxic Breathwork
This project will study changes that occur during a short period of intensive daily slow-paced breathing and breath hold practice (i.e., "breathwork").
- Conditions
- Hypoxic Breathwork With Music and Affirmative Messaging, Hypoxic Breathwork Only, Music and Affirmative Messaging
- Trial name
- NCT06317259
- Testing
- Hypoxic breathwork plus music and messaging, Hypoxic breathwork only, Music and messaging meditation
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy
Catecholamines Can Attenuate Intermittent Hypoxia-Induced Expression of TNF in Human Monocytes
Specific aim To examine the effect of catecholamines on the modulation of intermittent hypoxia induced TNF- in human monocytes from both healthy subjects and OSA patients (2).
- Trial name
- NCT00498862
- Where
- Taiwan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypoxemia
Effects of Acute Intermittent Hypoxia on Brain Function Imaging and Systemic Inflammation
Effects of acute intermittent hypoxia on brain function imaging and systemic inflammation Patients with obstructive sleep apnea (OSAS) may have neurological cognitive impairment. The reason is not clear.
- Trial name
- NCT03453697
- Testing
- acute intermittent hypoxia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Aging
Enhancing Cognition in Older Adults With Intermittent Hypoxia and Cognitive Training
The current study will investigate methods for enhancing cognitive training (CT) effects in healthy older adults by employing a combination of interventions facilitating neural plasticity and optimizing readiness for learning.
- Trial name
- EXCITE (NCT03957213)
- Testing
- Acute Intermittent Hypoxia, Computerized Cognitive Training
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hypoxia, Erythropoiesis
Effects of Intermittent Hypoxia Training With Iron Supplementation on Red Blood Cells and Iron Levels in Trained Athletes
This study investigates how training under conditions of reduced oxygen (intermittent hypoxia) affects the body's ability to produce red blood cells and manage iron levels, compared to training under normal oxygen conditions.
- Conditions
- Hypoxia, Erythropoiesis, Iron Metabolism Disorders
- Trial name
- IHIT-IRON (NCT07720960)
- Testing
- Control group (CG), Hypoxia group (HG): trained at simulated altitudes between 4,450 and 5,850 m
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Néstor Vicente-Salar
Obstructive Sleep Apnea of Adult
Impact of Intermittent Hypoxia on the Function of the Phagocytes
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA.
- Trial name
- NCT03618719
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Preconditioning
Personalized Hypoxic-hyperoxic Preconditioning in Elderly People
This study investigates an original protocol of personalized hypoxic-hyperoxic preconditioning utilizing a personalized approach on the basis of cerebral tissue oxygenation assessed with near-infrared spectroscopy.
- Trial name
- NCT07018895
- Testing
- FiO2 reduced by 20% alternating with 34% FiO2
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Obesity
Metabolism of Obese Women Under Exercise and Recovery Hypoxia
Obesity is characterized as a low-grade systemic inflammatory disease, which changes several pro-and anti-inflammatory cytokines.
- Trial name
- NCT05380830
- Testing
- Tied deep-Water Running
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Myocardial Ischemic-reperfusion Injury
Immunometabolic Pattern of Intermittent Hypoxia During ST-segment Elevation Myocardial Infarction
The aim of this study is to characterize the protective pattern of intermittent hypoxia, angina pectoris and remote ischemic conditioning, in reperfusion injury by determining and monitoring the plasma immunometabolic parameters…
- Trial name
- NCT05230966
- Testing
- Remote Ischemic Conditioning (RIC)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
INCOMPLETE SPINAL CORD INJURY (ASIA D), Able Bodied
Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function
The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.
- Trial name
- NCT06906536
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Preterm, Apnea of Prematurity
Efficacy of PIMUN by Reducing Intermittent Hypoxia Events
The goal of this clinical trial is to learn if the use of PIMUN(medical device) works to reduce the intermittent hypoxemia of 24-34 weeks of birth gestational age babies. . It will also learn about the safety of the use of PIMUN.
- Conditions
- Preterm, Apnea of Prematurity, Hypoxemia
- Trial name
- NCT07396103
- Testing
- Brain NIRS, Polysomnogram, Reactive oxydative species
- Where
- 2 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Spinal Cord Injuries
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323698
- Testing
- Caffeine, AIH
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Hypertension
Intermittent Hypoxia-hyperoxia Conditioning as a New Therapeutic Intervention to Reduce Hypertension (HyperIHHC)
The primary objective of this project is to examine the efficiency of intermittent hypoxia-hyperoxia conditioning (IHHC) protocol to improve vascular health and reduce blood pressure in hypertensive patients (stage 1).
- Trial name
- HyperIHHC (NCT05603676)
- Testing
- Intermittent hypoxia-hyperoxia conditioning
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gregoire Millet
Acute Mountain Sickness
Prevention of Acute Mountain Sickness by Intermittent Hypoxia
Acclimatization by mountaineering prior to high altitude sojourns have shown to be effective in prevention of acute mountain sickness (AMS).
- Trial name
- NCT00559832
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Healthy
Effect of Intermittent Hypoxia in Healthy Individuals
The use of acute intermittent hypoxia (AIH) has been examined in animal and human studies to gain an understanding of its effect on spinal excitability and synaptic strength.
- Trial name
- NCT04691518
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab