Clinical trials: Intermittent Hypoxia
Intermittent Hypoxia, Normoxia
Intermittent Hypoxia and Balance Control
This study aims to determine the effect of acute mild intermittent hypoxia on ankle plantarflexor muscle output during balance regulation and walking in younger and older adults.
- Trial name
- NCT05463042
- Testing
- Intermittent Hypoxia
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Incomplete Spinal Cord Injury
The Effect of Acute Intermittent Hypoxia on Motor Learning
The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.
- Trial name
- NCT05341466
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Intermittent Hypoxia
Intermittent Hypoxia and Inspiratory Threshold Loading to Enhance Inspiratory Muscle Function
Rehabilitation approaches introduce a stimulus to a motor system, with the goal to enhance motor function to patients. For example, exposure to brief and intermittent episodes of mild hypoxia has shown to strengthen synaptic…
- Trial name
- NCT03029559
- Testing
- Intermittent Hypoxia, Inspiratory Threshold Loading
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Spinal Cord Injuries
Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI
This study uses Magnetic Resonance Imaging to image the brain and spinal cord before and after an Intermittent Hypoxia intervention.
- Trial name
- NCT05183113
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Sleep Apnea, Age
Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep
The purpose for this research protocol was to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly.
- Trial name
- NCT00732199
- Testing
- 1) hyperventilation via noninvasive positive pressure ventilation 2) multiple trials of episodic hypoxia
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
OSA
Impact of Intermittent Hypoxia on Neutrophil Extracellular Traps
This prospective observational study will enroll 60 moderate-to-severe OSA patients (AHI≧15/hour, 30 obese [BMI>=27] \& 30 non-obese [BMI<27]) and 40 age-, gender-, BMI-matched controls without OSA.
- Trial name
- NCT05485688
- Testing
- sleep apnea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Ketosis, Hypoxia
Intermittent Exogenous Ketosis (IEK) at High Altitude
Altitude-related hypoxia decreases human functional capacity, especially during exercise. Even with prolonged acclimatization, the physiological adaptations are insufficient to preserve exercise capacity, especially at higher…
- Trial name
- NCT06097754
- Testing
- Ketone ester
- Where
- 2 sites in Belgium, Slovenia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Premature Birth, Intermittent Hypoxiema
Effect of Morning vs. Evening Vaccination on Hypoxia and Bradycardia of Preterm Infants: a Randomised Controled Trial
Hypoxia/bradycardia are common symptoms after vaccination of preterm infants. Adults show diurnal variations in vaccination response, due to circadian regulation of the immune system.
- Trial name
- NCT02640703
- Testing
- Infanrix + Prevenar 13
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes, Aging
IH, Brain Health, and T2D
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without…
- Trial name
- NCT07173543
- Testing
- Intermittent Hypoxia 1 (IH1), Intermittent Hypoxia 2 (IH2)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Darren P Casey
Healthy Aging
Effects of Different Moderate-intensity Exercise Methods on Health in the Elderly
Aging is linked to a higher risk of cardiovascular disease. Physical exercise is recognized as an excellent strategy to prevent cardiovascular diseases and cognitive aspects, generating healthier elderly people.
- Trial name
- 4MIIT (NCT05207501)
- Testing
- Exercise
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Amyotrophic Lateral Sclerosis (ALS), Neuromuscular Diseases
Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
This project seeks to investigate the effects of a single acute intermittent hypoxia (AIH) session on respiratory and non-respiratory motor function and EMG (electromyography) activity on patients with ALS (amyotrophic lateral…
- Trial name
- AIH-ALS (NCT03645031)
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida
Spinal Cord Injuries, Obesity
Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCI
The purpose of this research is to examine changes in blood glucose control and metabolism in individuals with SCI and non injured controls at rest and during exercise after five days of exposure to IH.
- Conditions
- Spinal Cord Injuries, Obesity, Insulin Resistance
- Trial name
- NCT02973438
- Testing
- Intermittent Hypoxia (IH)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injury
Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI
The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury.
- Trial name
- NCT01272349
- Testing
- Acute intermittent hypoxia, Room air
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Mountain Sickness, Healthy
Training in Hypoxia to Prevent Acute Mountain Sickness
Some studies suggest that high-altitude related illnesses - like acute mountain sickness - could be prevented by acclimatisation, reached at low altitude using training in simulated altitude.
- Trial name
- NCT00886912
- Testing
- hypoxia, normoxia
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Spinal Cord Injuries
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323945
- Testing
- AIH, Walk, Strength
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Sleep Apnea Syndrome
Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.
- Trial name
- NCT00746928
- Testing
- Chronic Intermittent Hypoxia
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Acute Mountain Sickness
The Effects of Intermittent Hypoxia on Acute Hypoxic Injury
This study intends to further reveal the effectiveness of intermittent hypoxia in preventing acute hypoxic injury.
- Trial name
- NCT05733338
- Testing
- Intermittent Hypoxia
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Altitude Hypoxia
Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance
The investigators expect to find that different intensity and altitude exposure levels will show what kind of intermittent exposure protocol is more beneficial to athletes and healthy individuals that experience acute exposure to…
- Trial name
- NCT03743610
- Testing
- Simulated altitude
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Apnea of Prematurity, Intermittent Hypoxia
Pilot Study to Evaluate Doses of Mechanical Stimulus on the Effectiveness of Preterm Breathing
The goal of this clinical trial is to compare, in healthy preterm babies, 9 doses of dorsal mechanical stimuli, in order to answer: if there is a dose of dorsal mechanical stimuli that improves the basal respiration.
- Trial name
- NCT06639581
- Testing
- 20 per minute stimulus, 30 per minute stimulus, 40 per minute stimulus
- Where
- Chile
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile