Clinical trials: Interstitial Liquid
Obesity, Type 2 Diabetes Mellitus
The Influence of Fatty-Acids on Systemic and Subcutaneous Cytokines
This is a mono-center randomized controlled trial to be performed in the Center of Medical Research (ZMF) at Medical University Graz and is composed by one screening visit (V1) and two study visits (V2 and V3).
- Trial name
- TNF4 (NCT00708266)
- Testing
- Openflow microperfusion catheter, Intralipid 20%, 0.9% Saline Solution
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Pulmonary Edema
Pulmonary Function at High-Altitude
Based on the findings of decreased vital capacity, decreased FEV1 and increased closing volume after ascent to high altitude, some investigators suggest the presence of a subclinical high altitude pulmonary edema (HAPE).
- Trial name
- NCT00604227
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Healthy
Study of Dermal Interstitial Fluid Collection With a Vacuum-Assisted Microneedle Device
This study evaluates the collection of dermal interstitial fluid using a vacuum-assisted microneedle device in healthy adult volunteers.
- Trial name
- MAP (NCT07867028)
- Testing
- Vacuum-Assisted Microneedle Device
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Pitteri
Opioid Use Disorder
Assessment of Methadone and Buprenorphine in Interstitial Fluid
The purpose of this research is to determine if common medications for opioid use disorder (i.e., buprenorphine/naloxone, buprenorphine, methadone) and their metabolites (norbuprenorphine [a metabolite of buprenorphine]…
- Trial name
- NCT05546229
- Testing
- Microneedle based interstitial fluid collection
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cari Health Inc.
Eczema, Atopic Dermatitis
Cutaneous Biomarkers in Atopic Eczema Using a Non-Invasive Micro-Suction Device in Babies
This project aims to establish whether an adapted extraction device is tolerable and will be able to measure chemical signals in baby's ISF.
- Conditions
- Eczema, Atopic Dermatitis, Atopic Eczema
- Trial name
- CARE (NCT07228962)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy, Psoriasis
Distribution of Secukinumab (AIN457) Into Dermal Interstitial Fluid After a Single Subcutaneous Administration of 300 mg
The proposed exploratory study aims to understand the in vivo skin distribution properties of subcutaneously (s.c.) administered AIN457 in psoriatic and healthy skin using open flow microperfusion (OFM).
- Trial name
- OFM ISF (NCT01539213)
- Testing
- secukinumab (AIN457)
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Univentricular Heart, Lymphatic Abnormalities
Lymphatic Function in Patients With a Fontan Circulation From Brazil
It is suggested that the elevated central venous pressure in patients with a Fontan circulation can provoke manifestation of lymphatic dysfunction, met as plastic bronchitis, peripheral oedema and most feared protein-losing…
- Conditions
- Univentricular Heart, Lymphatic Abnormalities, Lymphatic Edema
- Trial name
- NCT04394507
- Testing
- Near-Infrared Fluorescence imaging, Strain Gauge Plethysmography
- Where
- 2 sites in Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Epidermis, Ultraviolet Exposure
A Clinical Study to Evaluate the Efficacy and SPF of Two Test Materials According to an Adaptation of the Guidelines of the FDA Sunscreen Drug Products for Over-the-Counter Human Use
Approximately 70 subjects (35 subjects per light and dark group) will be enrolled in this clinical study (to complete with a minimum of 10 subjects per skin type (I-VI) to assess the effects of known UV Radiation dosage on light…
- Trial name
- NCT07789639
- Testing
- Hybrid sunscreen, Chemical sunscreen, No sunscreen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Good Molecules, LLC
Idiopathic Pulmonary Fibrosis (IPF)
Biomarker Discovery for Novel Drug Development in Idiopathic Pulmonary Fibrosis
Drug discovery can take many years especially since most studies to measure effectiveness depend on clinical outcomes like pulmonary function tests and hospitalizations.
- Trial name
- NCT01718990
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Intoxication
Development of LabPatch-alcohol as a Noninvasive Skin Patch to Detect Blood Alcohol Concentrations
This study is designed to test LabPatch-alcohol, a wearable, non-invasive biosensor Band-Aid like patch that is designed to detect real-time changes in interstitial alcohol concentrations in human subjects.
- Trial name
- NCT03242161
- Testing
- LabPatch-alcohol
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Type2 Diabetes, Atherosclerosis
Interstitial Fluid in the Development of Cardiovascular Disease
At a given level of serum cholesterol, patients with T2D have an increased risk of developing atherosclerosis compared with nondiabetic subjects.
- Trial name
- NCT03386097
- Testing
- Collection of interstitial fluid, skin biopsies and blood
- Where
- 4 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Pain, Inflammation
Study of Experimental Models of Pain and Inflammation.
The experimental pain model studied in this proposal show characteristics of an inflamed wound with a pro-inflammatory response.
- Trial name
- NCT01097902
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Martin Angst
Healthy Volunteers
Minimally Invasive Sensing of Beta-lactam Antibiotics
This study is an in-house feasibility study of a microneedle biosensor developed within Imperial College London.
- Trial name
- MISBL (NCT03847610)
- Testing
- Phenoxymethyl Penicillin, Microneedle array
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Skin Massage
Exploring the Cutaneous Immune Response to Skin Massage in Early Life
This project aims to study whether regular skin massage in babies induces cutaneous inflammation and whether this inflammatory response is amplified in those receiving daily (vs bi-weekly or no) skin massage over an 8 week…
- Trial name
- CUTIE (NCT07228728)
- Testing
- Skin Massage with Product
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- King's College London
Chronic Fatigue Syndrome, Fibromyalgia
Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
The purpose of this study is: 1. To identify specific set of proteins in the cerebrospinal fluid (fluid surrounding the brain and the spinal cord), that are believed to be seen in Chronic fatigue syndrome (CFS) patients, but not…
- Conditions
- Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Illness, Multiple Chemical Sensitivity
- Trial name
- NCT00810329
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Colloid Osmotic Pressure
Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma
The purpose of this study is to evaluate a method of sampling interstitial fluid from subcutaneous sewn wicks.
- Trial name
- NCT01044979
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Colloid Osmotic Pressure
Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma in Healthy and Sick Children
The purpose of this study is to measure colloid osmotic pressure in interstitial fluid and plasma in healthy children under two years, in asphyxiated babies and in children undergoing heart surgery.
- Trial name
- NCT01044940
- Where
- Norway
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Diabetes Mellitus, Type 2
ApoB48 Metabolism in Plasma and Interstitial Fluid
Postprandial increases in the levels of atherogenic chylomicron remnant lipoprotein particles have long been considered a presumable risk factor for the development of atherosclerosis with time, also in normolipidemic subjects.
- Trial name
- NCT03921203
- Where
- Sweden
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Adherence, Medication, Opioid Use Disorder
Assessing Dose Taken in Opioid Use Disordered Patients With an Electrochemical Sensor
CARI Health aims to develop a methadone dose taken sensor that provides real-time data on interstitial fluid (ISF) levels that could be used as a methadone adherence monitor for daily doses.
- Trial name
- NCT05998876
- Testing
- Remote Medication Monitor (RMM) - Prototype, Daily Methadone Dose
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cari Health Inc.
Colloid Osmotic Pressure
Measurement of Colloid Osmotic Pressure in Plasma and Interstitial Fluid in Children
The purpose of this study is to identify normal values of colloid osmotic pressure in interstitial fluid and plasma in healthy children between 2 and 10 years.
- Trial name
- NCT01044641
- Where
- Norway
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital