Clinical trials: Intervention Effectiveness
Depression
Improving Depression Via E-Health Access (IDEA) Study
The researchers are doing this study to learn more about which online self-help resources, including a smartphone app, an online program, or an informational website, primary care patients with depression are likely to choose and…
- Trial name
- NCT04689568
- Testing
- Moodkit, Moodgym, University of Michigan Depression Center Toolkit
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Adherence, HIV Risk Behaviors
The Aim of This Study is to Determine the Effectiveness of a Motivational Enhancement Intervention in Reducing Risk Behaviors (Drug and Alcohol Use, Sexual Risk Behavior, Poor Adherence to Medications) Among HIV+ Youth. - 1
The purpose of this study is to conduct a pilot study of Motivational Enhancement Therapy (MET), an empirically validated behavioral change strategy, with young adults who are HIV +.
- Conditions
- Adherence, HIV Risk Behaviors, Alcohol & Drug Use, Health Behaviors
- Trial name
- NCT00227825
- Testing
- Motivational interviewing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Problematic Behavior in Children, Parent-child Problem
Effectiveness of a Foster Parent Intervention: Results of a Trial
The hypothesis of the study is that the intervention leads to a reduction in foster children's externalizing problems and foster parents' parenting stress and that this in turn leads to a reduction in the number of breakdowns of…
- Trial name
- PVO (NCT01821755)
- Testing
- Foster parent intervention
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Focus of Study is STEMI
Phase 2 Clinical Proof-of-Concept Study of the Cardioprotective Properties of Danegaptide in ST Segment Elevation Myocardial Infarction
This study explores the potential cardioprotective properties of danegaptide when administered to patients with ST-Segment elevation myocardial infarction.
- Trial name
- NCT01977755
- Testing
- danegaptide
- Where
- Denmark
- Volunteers
- 591 people
- Sponsor
- Zealand Pharma
Symptoms of Depression and Anxiety
Effectiveness of a Guided Mental Health Chatbot for Youth Living in Lithuania
The study aims to assess the effectiveness of a guided mental health chatbot called "Scalable Technology for Adolescents and youth to Reduce Stress (STARS)", adapted for youth living in Lithuania.
- Trial name
- NCT07012876
- Testing
- STARS (Scalable Technology for Adolescents and youth to Reduce Stress), Basic psychoeducation
- Where
- Lithuania
- Volunteers
- 262 people
- Sponsor
- Vilnius University
Multiple Sclerosis
Comparative Effectiveness Study Telerehab Versus Conventional
This study aims to compare the effectiveness of an exercise program delivered in a conventional facility-based format versus a telerehabilitation format, which takes place in the home.
- Trial name
- NCT03468868
- Testing
- Exercise program for people with MS
- Where
- 9 sites in United States
- Volunteers
- 379 people
- Sponsor
- Shepherd Center, Atlanta GA
Sedentary Behavior, Exercise
One Step at a Time: An Intervention to Reduce Sedentary Behavior Among Working Adults
The proposed study will test the preliminary efficacy of a novel 12-week social cognitive theory-based intervention that will target reducing daily sitting time and increasing exercise participation among middle-aged working…
- Conditions
- Sedentary Behavior, Exercise, Middle Age, Adult
- Trial name
- NCT05281978
- Testing
- Decrease Sedentary Time + Increase MVPA group, Increase MVPA group
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Weight Loss, Gestational Diabetes Mellitus in Pregnancy
Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes
The goal of this clinical trial is to evaluate the effectiveness of a 6-month lifestyle intervention compared to Metformin in postpartum women who have delivered a singleton, live born infant within the last 12 weeks to 1 year…
- Conditions
- Weight Loss, Gestational Diabetes Mellitus in Pregnancy, Postpartum Care
- Trial name
- GooDMomS2 (NCT06948825)
- Testing
- Metformin Hcl 850Mg Tab, Lifestyle Intervention, Enhanced Lifestyle Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- George Washington University
Chronic Disease
Pilot Evaluation of "KeepWell" Using a Hybrid Effectiveness-Implementation Pragmatic Randomized Controlled Trial
The burden of chronic disease is a global phenomenon, particularly amongst seniors. Aging is an expensive process. In Canada, 10% of seniors who have the most complex health needs account for 60% of the total annual health care…
- Trial name
- NCT04437238
- Testing
- KeepWell tool, Control - Usual care
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- North York General Hospital
Autism Spectrum Disorder
Assessing the Effectiveness of Reciprocal Imitation Teaching in Part C Early Intervention Settings (Sprout Study)
Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system's capacity to provide such services is severely…
- Trial name
- NCT05425277
- Testing
- Reciprocal Intervention Teaching (RIT), Daily Routines
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Washington
Intimate Partner Violence (IPV), Norms, Social
What Works - Malawi SASA! Together
Violence against women is complex and must be addressed at multiple levels, with leadership from women themselves on how to bring about positive change to free women and girls from daily experiences of violence and to promote…
- Conditions
- Intimate Partner Violence (IPV), Norms, Social, Gender Inequitable Behavior
- Trial name
- WW-M-SASA! (NCT06783400)
- Testing
- SASA! Together
- Where
- Malawi
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- George Washington University
Major Depressive Disorder
Real-life Effectiveness of Vortioxetine in Depression
Worldwide Major Depressive Disorder (MDD) has significant negative personal, societal and economic consequences. Vortioxetine (Brintellix®) is a new antidepressant authorized since 2013.
- Trial name
- RELIEVE (NCT03555136)
- Testing
- Vortioxetine
- Where
- 106 sites in United States, Canada and 2 more
- Volunteers
- 992 people
- Sponsor
- H. Lundbeck A/S
Hemostasis of Arterial Punctures
Safety and Efficacy Study Comparing Thrombin for Arterial Sealing
This trial is designed as a prospective, multi-center, randomized, double blinded clinical trial to evaluate the safety and efficacy of the Thrombin VSI.
- Trial name
- NCT00388284
- Testing
- Arterial Sealing
- Where
- 6 sites in United States
- Volunteers
- 270 people
- Sponsor
- Vascular Solutions LLC
PTSD
TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD
Background: The poor prognosis and public health burden of PTSD necessitates the development of more effective and broader treatment approaches.
- Trial name
- NCT02766192
- Testing
- Ketamine, TIMBER Psychotherapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cooper Health System
COVID-19, Respiratory Disease
Post COVID-19 REspiratory Mechanisms and the Efficacy of a Breathing Exercise Intervention for DYsregulated Breathing
A pilot Study To investigate the efficacy of a breathing intervention for improving persistent breathlessness due to dysregulated breathing following COVID-19 when compared to usual care.
- Trial name
- REMEDY (NCT05732571)
- Testing
- Breathing techniques over 12 sessions / 6 weeks inc yoga
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Depression, Depressive Disorder
A Single Group Study of Empower@Home-an Internet Cognitive Behavioral Therapy Intervention
This is a single group study of a novel internet-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- NCT05384704
- Testing
- Empower@Home
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Michigan
Diabetes
Adolescent Fitness Assessment Program
The purpose of this study is to implement a peer modeling intervention to improve self-efficacy and aerobic fitness in obese youth.
- Trial name
- AFAP (NCT01382121)
- Testing
- Peer Modeling, Control
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Cancer
Feasibility, Acceptability, and Preliminary Efficacy of a Remotely-delivered Health Coaching Intervention for Cancer Survivors
This study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of an 8-week, remotely delivered health coaching intervention designed to improve: 1) targeted psychosocial mechanisms of action (behavioral…
- Trial name
- NCT07026214
- Testing
- Vitalis Cancer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dementia, Alzheimer Disease
Comparing Structured Retrieval Practice and Reading-Based Education for Dementia Caregivers
Caring for a person living with dementia can be stressful, and many family caregivers report limited access to effective educational resources for managing dementia-related behaviors and caregiver stress.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Stress
- Trial name
- NCT07413406
- Testing
- Structured Retrieval Practice, Reading-Based Education
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Virginia Wesleyan University
Diabetes Mellitus Type 2
Technology Intervention for Diabetes Engagement & Self-Care (TIDES)
The purpose of this 3 site, 24-week, Comparative Effectiveness Randomized Clinical Trial in Primary Care is to compare usual care to an online, multi-media, digital intervention for Persons with Type 2 Diabetes to Improve…
- Trial name
- TIDES (NCT01440530)
- Testing
- Educational Intervention, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 170 people
- Sponsor
- Geisinger Clinic
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