Clinical trials: Intervention Effectiveness
Severe Aortic Stenosis, Transcatheter Aortic Valve Replacement
Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH
The objective of this study is to assess the safety and efficacy of using bivalirudin instead of unfractionated heparin (UFH) in transcatheter aortic valve replacements (TAVR).
- Conditions
- Severe Aortic Stenosis, Transcatheter Aortic Valve Replacement, Aortic Valve Replacement
- Trial name
- BRAVO 2/3 (NCT01651780)
- Testing
- Bivalirudin, Unfractionated Heparin
- Where
- 33 sites in Canada, France and 5 more
- Volunteers
- 803 people
- Sponsor
- The Medicines Company
Carpal Tunnel Surgery
Effectiveness of Medical Hypnosis in Virtual Reality on Preoperative Anxiety in Carpal Tunnel Surgery
Anxiety is a predominant factor among patients prior to surgery, particularly in the context of outpatient surgery, where the speed of care and same-day discharge can exacerbate this stress.
- Trial name
- NCT07083180
- Testing
- Recreative activity, Medical Hypnosis by virtual reality
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Clinique MEGIVAL
Coronary Artery Disease, Percutaneous Coronary Intervention
Effectiveness and Safety of Abluminal Biodegradable Polymer Sirolimus-eluting Stent (GENOSS® DES)
In this study, the investigators evaluated the effectiveness and safety of using the GENOSS® DES, which has a biodegradable polymer only on the inner wall of the blood vessel, for patients(all-comers) with coronary artery disease…
- Trial name
- GENCOMX (NCT06086496)
- Testing
- GENOSS® DES Sirolimus Eluting Coronary Stent System
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Genoss Co., Ltd.
Hypertension, Cardiovascular Diseases
Efficacy of Counselling for the Prevention of Hypertension (ECoPH)
This study aims to evaluate the effectiveness of counseling interventions in promoting positive changes in hypertension markers among adult slum dwellers.
- Trial name
- ECoPH (NCT07012096)
- Testing
- counseling, leaflet and mhealth education for hypertension, Leaflets and mhealth education
- Where
- Bangladesh
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Bangladesh University of Health Sciences
Parenting Stress, Mental Health
Development & Validation of a Life Balance Program for Parents of Preschoolers: A Pilot Study
This study aims to examine the relationships among life balance, parenting stress, and mental health in parents of preschool children, and to develop an individualized life balance promotion program for this population.
- Conditions
- Parenting Stress, Mental Health, Occupational Balance
- Trial name
- NCT07669896
- Testing
- Occupational Balance Promotion Program
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Occupational Injuries
Effects of an OT Workstation Intervention on Knowledge, Self-efficacy, and Habit Formation
The study aims to determine whether a face to face ergonomic workstation intervention has any advantage over an online instructional training program for acquisition of knowledge, self-efficacy, and habit formation.
- Trial name
- NCT03174262
- Testing
- Ergonomic Computer Workstation Training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Piriformis Muscle Syndrome, Dry Needling
Efficacy of Ultrasound-Guided Dry Needling Therapy and Exercise in Piriformis Muscle Syndrome
Piriformis muscle syndrome (PMS) is a neuromuscular disorder that can cause symptoms of hip joint motion limitation, buttock pain and tenderness, and numbness radiating to the back of the thigh due to compression or irritation of…
- Conditions
- Piriformis Muscle Syndrome, Dry Needling, Ultrasonography, Ultrasound Guided Dry Needling
- Trial name
- NCT05962515
- Testing
- ultrasound guided dry needling
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Tepecik Training and Research Hospital
Autism Spectrum Disorder
Play Based Approach Among Autism
This pilot study evaluates the effectiveness of the B.A.S.I.C.S. framework, a multimodal play-based intervention designed for children with autism spectrum disorder (ASD).
- Trial name
- NCT07814040
- Testing
- B.A.S.I.C.S FRAMEWORK, Conventional Physiotherapy
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Saveetha University
Spinal Muscular Atrophy
A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy
The primary objective of the study is to examine the clinical efficacy of nusinersen (ISIS 396443) administered intrathecally (IT) to participants with infantile-onset with infantile-onset spinal muscular atrophy (SMA).
- Trial name
- ENDEAR (NCT02193074)
- Testing
- nusinersen
- Where
- 31 sites in United States, Australia and 11 more
- Volunteers
- 122 people
- Sponsor
- Biogen
Opioid Use Disorder
NavSTAR Implementation Effectiveness Trial Across a Health System
Patient Navigation (PN) interventions following hospitalization can improve outcomes for people with opioid use disorder treatment.
- Trial name
- Philly NavSTAR (NCT07262190)
- Testing
- NavSTAR (Philly adaptation)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Friends Research Institute, Inc.
Metastatic Breast Cancer
Non-interventional Study With Nab-Paclitaxel (Abraxane®)
The purpose of this non-interventional study is to collect data on the efficacy and safety of Nab-Paclitaxel in the routine application.
- Trial name
- NABUCCO (NCT01689610)
- Where
- Germany
- Volunteers
- 705 people
- Sponsor
- iOMEDICO AG
Physical Activity, Adolescent Behavior
TWOgether - From Sport Zero to Sport Hero
BACKGROUND: The physiological and psychological benefits of regular physical activity (PA) and reduced sedentary behavior are well documented.
- Conditions
- Physical Activity, Adolescent Behavior, Health Behavior
- Trial name
- TWOgether (NCT03575559)
- Testing
- Individual planning, Collaborative planning, Education and motivation treatment
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Virtual Reality, Drug Sedation
the Effectiveness of Therapeutic Virtual Reality Versus Pharmacological Sedation on Pain and Anxiety During Interventional Cardiology Procedures
Immersion sedation in virtual reality could be an alternative to conventional pharmacological sedation, during interventional cardiology acts on pain and anxiety control.
- Conditions
- Virtual Reality, Drug Sedation, Coronarography, Angiography
- Trial name
- VirtuCardio (NCT05588232)
- Testing
- scheduled outpatient interventions in interventional cardiology
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Elsan
Developmental Disability
Developing and Examine the Efficacy of the Family-Centered Multi-Sensory Environment Intervention on Parent's Empowerment and Children's Engagement (MSE-PEACE) in Children With Developmental Disabilities and Their Parents: A Mixed Methods Study
The goal of this clinical trial is to learn whether a family-centered multi-sensory environment (MSE-PEACE) can help children with developmental disabilities and support their parents.
- Trial name
- MSE-PEACE (NCT07118293)
- Testing
- MSE-PEACE
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Dehydration, Symptom Cluster
Culturally Tailored Nurse Coaching Study for Cancer Symptom Management
The purpose of the study is to see whether or not a telephone/ text message intervention, delivered by a registered nurse, is helpful in managing symptoms and can also prevent dehydration caused by chemotherapy treatment when…
- Conditions
- Dehydration, Symptom Cluster, Quality of Life, Self Efficacy
- Trial name
- NCT04874584
- Testing
- CTNSM, Standard of Care Chemotherapy Education
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Miami
Smoking Cessation
Multicentric Randomized Clinical Trial to Evaluate the Long-term Effectiveness of a Motivational Intervention Against Smoking, Based on the Information Obtained From Spirometry in Primary Care.
There is controversy about the effectiveness of interventions based on spirometry for smoking cessation. The investigators want to evaluate the effectiveness of motivational intervention performed by a doctor to obtain abstinence…
- Trial name
- RESET-ESPITAP2 (NCT02153047)
- Testing
- Spirometry
- Where
- Spain
- Volunteers
- 1,100 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Smoking Cessation
Study Comparing Two Stop Smoking Intervention Efficacies
The proposed study will compare the efficacy of two psychological stop smoking interventions.
- Trial name
- NCT02855255
- Testing
- NHS 1-1 smoking cessation programme., Group smoking cessation programme
- Where
- United Kingdom
- Volunteers
- 620 people
- Sponsor
- London South Bank University
End-Stage Kidney Disease (ESKD), Maintenance Hemodialysis (MHD)
Health Coaching for Self-Management in Maintenance Hemodialysis Patients
This study is a quasi-experimental study designed to evaluate the effects of a health coaching intervention on self-management ability in patients undergoing maintenance hemodialysis.
- Trial name
- NCT07685626
- Testing
- Health Coaching, Routine Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
ASD, Child Behavior Problem
Autism and Disruptive Behavior Trial
Investigators seek to transform the delivery of health care to children with autism spectrum disorder (ASD) and behavioral health problems (and their families) by developing an innovative tiered set of interventions.
- Trial name
- NCT04204226
- Testing
- Social Worker, Autism Behavioral Health Navigation (ABHN), Social work + ABHN
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital of Philadelphia
Coronary Artery Disease
Safety and Efficacy of "Standardized" CHIP
In routine clinical practice, high-risk patients with high-risk anatomies are more often referred for interventional treatment by percutaneous coronary interventions (PCI).
- Trial name
- NCT03212378
- Testing
- percutaneous coronary interventions
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital, Essen
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