Clinical trials: Intervention Phase
Cancer Survivor, Stage 0 Breast Cancer AJCC v6 and v7
Kindness Interventions in Enhancing Well-Being in Breast Cancer Survivors
Emerging evidence suggests that both extending kindness towards others and self-kindness practices may have beneficial effects on well-being.
- Conditions
- Cancer Survivor, Stage 0 Breast Cancer AJCC v6 and v7, Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7
- Trial name
- NCT03319342
- Testing
- Behavioral Intervention, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Melanoma
Teaching Skin Self-Examination to First-degree Relatives of Melanoma Patients Using Mobile App Technology
The proposed study builds upon the success of our research program (STU00017005: Interventions to teach melanoma patients skin self-examination and the continuation STU0201983) designed to increase early detection of melanomas…
- Trial name
- NCT03177941
- Testing
- Eviderma Smart Phone Teledermatology Application (Eviderma)
- Where
- United States
- Sponsor
- Northwestern University
End-Stage Kidney Disease, Renal Dialysis
The Impact of Different Citrate Concentrations as Locking Solutions on Development of Biofilm and Function of Hemodialysis Catheters
Evidence that supports using certain concentration of trisodium citrate as a locking solution for hemodialysis catheters has not yet been established.
- Conditions
- End-Stage Kidney Disease, Renal Dialysis, Central Venous Catheter, Biofilms
- Trial name
- NCT03683563
- Testing
- 4% sodium citrate, 30% sodium citrate
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Non-small Cell Lung Cancer, Cardiovascular Complication
Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients
This is a prospective, randomized, controlled, multi-center phase III clinical trial that intends to evaluate the role of early cardiovascular intervention based on impedance cardiography in patients with locally advanced…
- Trial name
- NCT04980716
- Testing
- Multiple cardiovascular drugs related to "Golden Triangle"
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Sun Yat-sen University
End Stage Renal Disease
Transplant Navigator Intervention to Overcome Barriers to Kidney Transplantation
Compared with chronic dialysis treatment, kidney transplantation generally offers a longer life span, a better quality of life, and lower health care costs for the over 500,000 Americans with End Stage Renal Disease.
- Trial name
- NCT00805038
- Testing
- Transplant navigator, Usual care
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Case Western Reserve University
Cutaneous T Cell Lymphoma, Mycosis Fungoides
Photopheresis in Early-stage Mycosis Fungoides
The purpose of this study is to determine whether photopheresis therapy can be used to improve the clinical course of early stage cutaneous T-cell lymphoma (CTCL).
- Trial name
- NCT05680558
- Testing
- UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis, THERAKOS® CELLEX photopheresis system
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Columbia University
Osteopathic Medicine, Effectiveness
The Quality of Life in Children at Social Risk, a Case Series Study Protocol
this case series study has the aim to observe the effect of a multidisciplinary intervention (social accompaniment, school reinforcement and osteopathic treatment) on the quality of life of children with social risk in primary…
- Trial name
- NCT05135780
- Testing
- Osteopathic manual treatment, Social education
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Francesco Cerritelli
Mantle Cell Lymphoma
Zanubrutinib Plus Rituximab for Patients With Indolent Mantle Cell Lymphoma
Phase II, multicentre, randomised, open-label study to assess the benefit of early intervention with fixed duration, time-limited zanubrutinib-rituximab in indolent mantle cell lymphoma (MCL)
- Trial name
- ZEBRA (NCT05635162)
- Testing
- Zanubrutinib, Rituximab
- Where
- 13 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Malaria
A Study to Assess the Safety and Immunogenicity of a Vaccine Against Malaria in Healthy Children Aged 5-60 Months
The purpose of this study is to evaluate the safety and immunogenicity of reduced antigen doses and alternative vaccination regimes for RTS,S/AS01E in healthy children aged 5-60 months in a malaria-endemic area.
- Trial name
- NCT07036159
- Testing
- RTS,S/AS01E vaccine
- Where
- 2 sites in Rwanda
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastric Cancer, Chemotherapy, Adjuvant
The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients.
The goal of this randomized clinical trial is to investigate whether pressurized intraperitoneal chemotherapy (PIPAC), delivered immediately after minimally invasive D2 gastrectomy and repeated 6-8 weeks later, improves 12-month…
- Conditions
- Gastric Cancer, Chemotherapy, Adjuvant, Peritoneal Metastases, Minimally Invasive Surgical Procedures
- Trial name
- EPICURE (NCT06295094)
- Testing
- Cisplatin, Doxorubicin
- Where
- 5 sites in United States, Denmark and 3 more
- Volunteers
- 264 people
- Sponsor
- Odense University Hospital
Hepatitis B, Chronic
A Study of JNJ 73763989+JNJ 56136379+Nucleos(t)Ide Analog (NA) Regimen Compared to NA Alone in e Antigen Negative Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection
The purpose of this study is to evaluate the efficacy of 48-week study intervention with JNJ-73763989+JNJ-56136379+nucleos(t)ide analog (NA) regimen compared to NA alone assessed by HBsAg levels.
- Trial name
- NCT04129554
- Testing
- JNJ-73763989, JNJ-56136379, Entecavir (ETV) monohydrate
- Where
- 41 sites in Belgium, France and 5 more
- Volunteers
- 130 people
- Sponsor
- Janssen Sciences Ireland UC
Segmentectomy
Segmentectomy After Induction Therapy (SAINT)
The primary objective will be to determine the feasibility of performing a high-quality sublobar anatomic resection (segmentectomy) with R0 margin status on final pathology for patients who received induction therapy for NSCLC…
- Trial name
- SAINT (NCT06496659)
- Testing
- Segmentectomy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Malignant Melanoma
A National Phase IV Study With Ipilimumab for Patients With Advanced Malignant Melanoma.
The goal of this study is to understand how ipilimumab is being used, its safety profile, and the manner in which Adverse Reactions are managed in routine clinical practice. Another goal is to identify predictive biomarkers.
- Trial name
- Ipi4 (NCT02068196)
- Testing
- Blood sampling for Pre-existing immunity, Ipilimumab
- Where
- 8 sites in Norway
- Volunteers
- 150 people
- Sponsor
- Oslo University Hospital
Stroke
Home-based -Virtual Reality Intervention for Stroke Rehabilitation
On-going rehabilitation is needed to maintain and improve the weaker upper extremity following stroke. Community rehabilitation programs for stroke individuals in the chronic stage are often difficult to be implement.
- Trial name
- Home-VR (NCT02393170)
- Testing
- self-training using video-games, traditional self-training
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
This study is being done to find out if a new medicine called PF-08634404, when given with chemotherapy, works better than the present standard treatment (pembrolizumab with chemotherapy) for adults with a type of lung cancer…
- Conditions
- Advanced Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC)
- Trial name
- NCT07222566
- Testing
- PF-08634404, Pembrolizumab, Chemotherapy Regimen 1
- Where
- 484 sites in United States, Argentina and 18 more
- Volunteers
- 1,410 people
- Sponsor
- Pfizer
Cigarette Smoking
Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive Symptoms
Depression related vulnerabilities are highly comorbid with smoking behavior and dramatically reduce cessation rates among both community and clinical samples.
- Trial name
- NCT01199380
- Testing
- Standard Treatment, Behavioral Activation Treatment for Smoking, Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Maryland, College Park
HIV Infections
A Study of Peer Education to Prevent HIV Transmission Among Injection Drug Users and Their HIV Risk Contacts
Injection drug use is the major mode of HIV transmission in many countries. Injection drug users (IDUs) transmit HIV not only through shared drug injection equipment but also through heterosexual and homosexual transmission and…
- Trial name
- NCT00038688
- Testing
- Peer HIV Education Program
- Where
- 3 sites in United States, Thailand
- Volunteers
- 2,610 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Binge-Eating Disorder
Reduction of the Speed of Eating as an Intervention in Obesity
Patients diagnosed with Binge Eating Disorder (BED) overeat food but, as opposed to patients with bulimia nervosa, they do not compensate for their increased food intake and therefore their body weight increases.
- Trial name
- NCT02381327
- Testing
- Mandometer
- Where
- Sweden
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Mando Group AB
Prehypertension, Hypertension
Efficacy of Nigella Sativa (Nisatol®) in Women With Borderline Blood Pressure Values or a Non-Dipper Blood Pressure Phenotype
This randomized placebo-controlled study evaluates the efficacy of Nigella sativa (Nisatol®) supplementation in women with borderline blood pressure values or a non-dipper blood pressure phenotype.
- Trial name
- NCT07494279
- Testing
- Nigella sativa (Nisatol®)
- Where
- Italy
- Volunteers
- 106 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Alcohol Use, Alcohol Drinking
Multi-Component Breath Alcohol Intervention Phase 3
This is the third stage of a three-stage, NIH-funded study to develop and test a multi-modal intervention concerning blood/breath alcohol concentration for young adults who drink heavily.
- Conditions
- Alcohol Use, Alcohol Drinking, Drinking Behavior
- Trial name
- BAMTECH (NCT06994962)
- Testing
- Alcohol-related mobile health technologies, Motivational interview and psychoeducation on blood/breath alcohol concentration, Lower tech facilitation
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Northeastern University
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