Clinical trials: Interventions
Weight Gain During Pregnancy
A Smartphone Intervention for WIC Mothers to Improve Nutrition and Weight Gain During Pregnancy
The study will test the effectiveness of a smartphone-based behavior modification program adapted for use in Women, Infants, and Children program in a state-wide, randomized controlled trial in 432 low-income women enrolled in…
- Trial name
- SmartMomsinWIC (NCT04028843)
- Testing
- Healthy Beginnings
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Caregiver, Stage I Lung Cancer AJCC v7
Multimedia Self-Management Intervention for Lung Cancer Surgery Family Caregivers and Patients
This randomized phase III trial studies how well a multimedia self-management intervention works in preparing family caregivers and patients with stage I-III lung cancer for lung cancer surgery.
- Conditions
- Caregiver, Stage I Lung Cancer AJCC v7, Stage IA Lung Cancer AJCC v7, Stage IB Lung Cancer AJCC v7
- Trial name
- NCT03686007
- Testing
- Informational Intervention, Media Intervention
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- City of Hope Medical Center
HIV, AIDS
Personalized Text Messages to Improve Antiretroviral Treatment (ART) Adherence in HIV+ Methamphetamine Users
Methamphetamine (METH) is a debilitating and frequently abused substance that is often comorbid with HIV infection. HIV+ persons with current METH abuse or dependence (HIV+/METH+) have several characteristics, in addition to…
- Trial name
- iTAB (NCT01317277)
- Testing
- individualized Texting for Adherence Building (iTAB), Psychoeducation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, San Diego
Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
Biological Signatures, Probiotic Among Those With mTBI and PTSD
Exaggerated inflammation in the body and brain is thought to play a role in the vulnerability to and aggravation and perpetuation of adverse consequences among those with co-occurring mild TBI (mTBI) and post-traumatic stress…
- Trial name
- NCT02723344
- Testing
- of Lactobacillus reuteri (L. reuteri; DSM 17938), Sunflower and medium chain triglyceride oils
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- VA Office of Research and Development
Family Mindfulness-based Intervention in War-affected Families, Intergenerational Trauma
FMBI With War-affected Families
This study has two central research questions: 1) Is implementing a family mindfulness-based intervention with war-affected immigrant families through community based participatory research methods feasible?; and 2) Does the…
- Conditions
- Family Mindfulness-based Intervention in War-affected Families, Intergenerational Trauma, War-Related Trauma
- Trial name
- NCT05241314
- Testing
- Learning to BREATHE, After Deployment Adaptive Parenting Tools (ADAPT)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Prostate Cancer
Prostate Cancer Intervention Versus Observation Trial (PIVOT)
Radical prostatectomy provides potentially curative removal of the cancer. However, it subjects patients to the morbidity and mortality of the surgery and may be neither necessary nor effective.
- Trial name
- PIVOT (NCT00007644)
- Testing
- Radical prostatectomy
- Where
- 31 sites in United States
- Volunteers
- 731 people
- Sponsor
- VA Office of Research and Development
Obesity
A Primary Care Behavioral Approach for Addressing Childhood Overweight
The purpose of this study is to determine whether participation in a group-based health education curriculum is superior to receipt of standardized health educational materials for children who are overweight or at risk for…
- Trial name
- NCT00284557
- Testing
- Group-based behavioral intervention
- Volunteers
- 130 people
- Sponsor
- Emory University
Nonsquamous Non-small Cell Lung Cancer
Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)
The purpose of this study is to assess the safety and efficacy of pemetrexed + platinum chemotherapy + pembrolizumab (MK-3475) with or without lenvatinib (MK-7902/E7080) as first-line intervention in adults with metastatic…
- Trial name
- NCT03829319
- Testing
- Pembrolizumab, Carboplatin, Cisplatin
- Where
- 158 sites in United States, Argentina and 15 more
- Volunteers
- 761 people
- Sponsor
- Merck Sharp & Dohme LLC
Suicide, Suicide Prevention
Suicide Prevention Integration Into Task-shifted Mental Health Interventions
Investigators will conduct a pilot clinical trial to assess the feasibility and acceptability of implementing a Suicide Prevention Package (SuPP) within an existing task-shifted depression intervention in rural Pakistan.
- Conditions
- Suicide, Suicide Prevention, Suicidal Ideation
- Trial name
- KPZ (NCT06208293)
- Testing
- KPZ Program (KPZ), Enhanced Usual Care (EUC)
- Where
- Pakistan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV Infections, Sexually Transmitted Diseases
Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment
The overall goal of this 3-arm randomized trial is to test whether a network-driven online intervention tailored for intersectional stigma amelioration can elicit online social support, promote intervention engagement, and…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Stigma, Social
- Trial name
- NCT03678181
- Testing
- Information Resources, Social Support, HIV Testing
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Quality of Life, Self Efficacy
Oral Health Education Interventions Among Seniors
The study aims to assess the efficacy of an oral health education group based activity versus an individual based oral health education activity in terms of changes in oral health related quality of life (OHRQoL), self-efficacy…
- Conditions
- Quality of Life, Self Efficacy, Knowledge
- Trial name
- NCT03301714
- Testing
- Oral Health Education
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Temple University
Social Anxiety Disorder, Social Anxiety
Assessing Mechanisms of Anxiety Reduction in Animal-assisted Interventions
Adolescence and young adulthood is a critical period for the development of social anxiety, which is often linked to other mental health challenges such as depression, mood disorders, and substance abuse.
- Conditions
- Social Anxiety Disorder, Social Anxiety, Social Anxiety Disorder of Childhood
- Trial name
- NCT03249116
- Testing
- animal-assisted intervention, active control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tufts University
Depression
Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder
To evaluate the effectiveness of one algorithm for Major Depression Disorder (MDD) using medications available in the Brazilian Public Healthcare System (SUS), and assessment of the quality of life of these patients.
- Trial name
- NCT02901249
- Testing
- sertraline, Nortriptyline, Lithium
- Volunteers
- 68 people
- Sponsor
- Federal University of Rio Grande do Sul
PreDiabetes, Prediabetic State
Implementation and Evaluation of a Diabetes Prevention Clinical Pathway in Primary Care
Prediabetes is a significant public health problem affecting 88 million U.S. adults. Evidence suggest that the vast majority of people with prediabetes are unaware of having this condition and many are not receiving appropriate…
- Trial name
- NCT05265312
- Testing
- START diabetes prevention clinical pathway
- Where
- United States
- Volunteers
- 1,910 people
- Sponsor
- Johns Hopkins University
Maternal Substance Use, Child Abuse and Neglect
Stage I Randomized Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers
The primary goal of this Stage I therapy development study will be to manualize and test the preliminary efficacy of a parenting intervention for drug dependent mothers that aims to foster their ability to recognize children's…
- Trial name
- NCT00319436
- Testing
- Mentalizing Therapy for Substance Using Mothers, Standard Parent Education for Substance Using Mothers
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yale University
Major Depressive Disorder
The BIomarker Guided (BIG) Study for Depression
Cognitive impairments contribute significantly to psychosocial dysfunction in major depressive disorder (MDD) and respond poorly to conventional antidepressants, yet selective treatments targeted to these impairments are lacking.
- Trial name
- NCT04181736
- Testing
- Guanfacine Tablets
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Stanford University
Prevention or Reduction of HIV Risk Behavior, Prevention or Reduction of Intimate Partner Violence
Schools Championing Safe South Africa
This study explores the acceptability and feasibility of a school-based intervention called Schools Championing Safe South Africa that engages teachers and students in an integrated approach for preventing risk behavior related…
- Trial name
- NCT05869864
- Testing
- Schools Championing Safe South Africa
- Where
- South Africa
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Brown University
Adolescent, Bullying
Online Bullying Bystander Intervention for Middle Schools Phase II
School interventions to reduce bullying can be effective but also require substantial time and resources. Online technologies have the potential to deliver effective bullying interventions to a large number of middle school…
- Conditions
- Adolescent, Bullying, Technology, Mental Health
- Trial name
- STACII (NCT05572398)
- Testing
- STAC-T
- Where
- 2 sites in United States
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Migraine, Depression
Brief Behavioral Intervention for Comorbid Migraine and Depression
The purpose of this research study is to examine whether a one-day group workshop, integrating principles from Acceptance and Commitment Therapy with Migraine Education, will result in improvements in depressive symptoms and…
- Trial name
- ACT-IM (NCT01775852)
- Testing
- ACT-IM
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Lilian N. Dindo
HIV, AIDS
Adherence Support Intervention for Persons Living With HIV/AIDS (PLWHA) on Antiretroviral Therapy (ART) in Estonia
The specific aim of the study is to assess antiretroviral therapy adherence and evaluate the impact of a situated treatment adherence intervention program among persons living with HIV/AIDS on antiretroviral therapy in Estonia.
- Conditions
- HIV, AIDS, Medication Adherence
- Trial name
- NCT01789138
- Testing
- Situated Optimal Adherence Intervention
- Where
- 2 sites in Estonia
- Volunteers
- 519 people
- Sponsor
- University of Tartu
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