Clinical trials: Interventions
Prediabetes, Obesity & Overweight
Postprandial Glucose Kinetics After Carbohydrate Restriction
The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals…
- Conditions
- Prediabetes, Obesity & Overweight, Diet Interventions, Carbohydrate Metabolism
- Trial name
- NCT07802275
- Testing
- Low-carbohydrate diet, Mediterranean Diet
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Bladder Pain Syndrome, Educational Behavioral Intervention
Mirogabalin Plus EBMP for IC/BPS
The goal of this clinical trial is to learn whether adding mirogabalin to educational-behavioral modification program (EBMP) improves symptoms and safety outcomes for adults living with interstitial cystitis/bladder pain syndrome…
- Conditions
- Bladder Pain Syndrome, Educational Behavioral Intervention, Urinary Urgency
- Trial name
- M-EBMP-IC/BPS (NCT07803393)
- Testing
- Behavioral: Educational and Behavioral Management Program (EBMP), Intervention
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Developmental Language Disorder, Explicit Intervention
Evaluation of an Explicit Approach
This study is a randomized clinical trial that uses a Sequential Multiple Assignment Randomized Trial (SMART) study design. The study will directly compare the efficacy of an innovative intervention that combines explicit and…
- Conditions
- Developmental Language Disorder, Explicit Intervention, Grammatical Language
- Trial name
- NCT04902508
- Testing
- Implicit-only, Explicit-added
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Minnesota
Coronary Artery Disease, Diffuse Coronary Artery Disease
Hybrid Percutaneous Coronary Intervention Combining a Bioresorbable Scaffold With Drug-coated Balloons Versus a Conventional Drug-eluting Stent-based Strategy in Patients With Long and Diffuse Coronary Artery Disease
The primary objective of the study is to assess the safety and the efficacy of a hybrid percutaneous coronary intervention (PCI) strategy combining a magnesium-based sirolimus-eluting bioresorbable scaffold (Freesolve, Biotronik…
- Conditions
- Coronary Artery Disease, Diffuse Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
- Trial name
- BIOHYBRID (NCT06710210)
- Testing
- PCI with a bioresorbable scaffold and drug-coated balloon(s), PCI with drug-eluting stent(s)
- Where
- 4 sites in Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Geneva
Second Victim Phenomenon, Occupational Stress
RESCUE: European Certification for Second Victim Support
The "second victim" phenomenon affects healthcare professionals who experience highly stressful events in their daily practice, potentially compromising their well-being and patient safety.
- Conditions
- Second Victim Phenomenon, Occupational Stress, Healthcare Workforce Well-Being, Patient Safety
- Trial name
- NCT06888297
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction
CORonary Thrombus Modification to Prevent MIcrovascular Damage in Patients With ST-segment Elevation Myocardial Infarction (The CORMI Trial)
The aim of this study is to evaluate the effects of coronary thrombus modification on preventing the microvascular damage associated with primary percutaneous coronary intervention (PCI), and to limit the associated myocardial…
- Conditions
- ST Elevation Myocardial Infarction, Coronary Microvascular Dysfunction, Percutaneous Coronary Intervention
- Trial name
- NCT07646977
- Testing
- Coronary thrombus modification, Standard stent implantation
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Parenting Intervention, Anger
Digital Behavioral Parenting Programs With and Without Added Emotion Regulation Strategies to Manage Anger in Parenting
This pilot randomized controlled trial evaluates the feasibility, acceptability, and preliminary effects of two digital parenting interventions for parents experiencing difficulties with anger in parenting.
- Conditions
- Parenting Intervention, Anger, Emotion Regulation Difficulties, Parenting Behaviour
- Trial name
- NCT07795684
- Testing
- Online Behavioral Parent Training Program, Online Behavioral Parent Training + Emotion Regulation Program
- Where
- 5 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Anxiety, Prostate Cancer
proState Cancer Health Education to pRomote Early sreENing Uptake (SCREEN): A Pilot Randomised Control Trial
Prostate cancer is an issue of significant public health concern. Yet in low- and middle-income countries like Nigeria, men are adversely affected due to factors including poor early prostate cancer screening uptake.
- Conditions
- Anxiety, Prostate Cancer, Health Education, Screening and Brief Interventions
- Trial name
- SCREEN (NCT07800390)
- Testing
- proState Cancer awareness education to pRomote Early screENing uptake, Control group
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Teesside University
Sexual Health, Mobile Application
Girls on Sexual Communication
Adolescents' sexual health has been an important issue for health care professionals, education and society. The purpose of this study was to examine the impact of a mobile application on adolescent girls' sexual communication…
- Conditions
- Sexual Health, Mobile Application, Female Adolescents, Dyadic Sexual Communication
- Trial name
- Girls (NCT07800728)
- Testing
- Girls
- Where
- Taiwan
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Diet Interventions, Diabetes Mellitus
Correlation Between Dietary Patterns, Anthropometric Profiles, Genetic Profiles, and Biomarker Levels to Diabetes
The goal of this clinical trial is to explore the correlation between dietary patterns, anthropometric measurements, genetic profiles, and biomarker levels and their impact on glucose levels and other relevant biomarkers in…
- Trial name
- NCT07800884
- Testing
- diet intervention
- Where
- Indonesia
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
MISC Intervention, Treatment as Usual
MISC-IPV: A Community-Based Intervention for Children Traumatized by Intimate Partner Violence
This study adapts and evaluates preliminary outcomes of the Mediational Intervention for Sensitizing Caregivers (MISC) for women and children of color who have survived domestic violence.
- Trial name
- MISC-IPV (NCT05948631)
- Testing
- MISC intervention, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Houston
Nutritional Intervention, Cancer
Early Nutritional Intervention in Patients With Cancer
The goal of this intervention study is to study the effect of nutritional interventions in patients with cancer receiving palliative chemotherapy.
- Conditions
- Nutritional Intervention, Cancer, Malnutrition
- Trial name
- NICOS (NCT06141785)
- Testing
- Nutritional intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Gødstrup Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention
Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy
The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20 mg once daily) for protection of GI events in patients with known…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- PROTECT-HBR (NCT04416581)
- Testing
- PPI, P-CAB 50
- Where
- 45 sites in South Korea
- Volunteers
- 3,320 people
- Sponsor
- Duk-Woo Park, MD
Chronic Kidney Disease, Diet Interventions
Dine and DASH Into Wellness Pilot Study
The purpose of this study is to determine the feasibility and acceptability of a16-week diet coaching program enhanced with cooking classes to improve adherence to the Dietary Approaches to Stop Hypertension (DASH) diet among…
- Conditions
- Chronic Kidney Disease, Diet Interventions, Disease Prevention
- Trial name
- NCT07175896
- Testing
- Immediate delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program, Delayed delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Neoplasms, Sleep Initiation and Maintenance Disorders
Electrical Grounding and Sleep Quality in Hospitalised Patients With Cancer
Sleep disturbance is one of the most common and most persistent symptoms in patients admitted for cancer care, and the options available during a short hospital stay are limited.
- Conditions
- Neoplasms, Sleep Initiation and Maintenance Disorders, Sleep Quality, Cancer
- Trial name
- NCT07791628
- Testing
- Earthing patch; grounding electrode
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Chang Gung Memorial Hospital
Child, Sleep
Effectiveness of the Sleep Island WeChat Mini-Program for Promoting Sleep in Preschool Children
Behavioral sleep problems are common during the preschool years and are strongly influenced by parental sleep-related practices and the home environment.
- Conditions
- Child, Sleep, Promotion, Digital Intervention
- Trial name
- Sleep Island (NCT07792577)
- Testing
- Sleep Island (安睡岛) Digital Behavioral Sleep Promotion Program
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Bronchoscopic Interventions
Single Use Bronchoscopes for Interventional Pulmonology
The goal of this pilot single-arm crossover trial is to investigate the feasibility and safety of using single-use flexible bronchoscopes (SUFB) for routine diagnostic and therapeutic interventional pulmonary procedures instead…
- Trial name
- NCT06596655
- Testing
- Single use bronchoscope
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Suicidal Ideation, Suicidal
Reward Sensitivity Digital Intervention for Suicide Risk
The goal of this clinical trial is to develop and test an app designed to reduce suicide risk and improve emotional well-being in adolescents.
- Conditions
- Suicidal Ideation, Suicidal, Suicidal Thoughts, Digital Health Intervention
- Trial name
- DIGIReward (NCT07661901)
- Testing
- Suicide prevention treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Youth Mental Health, Psychological Distress in Adolescents and Young Adults
VIPeerAgent for Adolescent Mental Health
This three-arm parallel randomized controlled trial aims to evaluate the effectiveness of VIPeerAgent, a virtual peer support agent, in improving mental health outcomes among adolescents and young adults aged 14-25 years…
- Conditions
- Youth Mental Health, Psychological Distress in Adolescents and Young Adults, Early Intervention
- Trial name
- NCT07778758
- Testing
- Virtual Peer Agent Intervention, Human peer mentor
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-sen University
Women's Health, Obesity & Overweight
Digital Resistance Training for Midlife Women Using GLP-1
The goal of PLAN-RT 1.0 to learn if a 12-week app-based strength training program can help midlife women build and stick with a regular strength training routine while they are taking GLP-1 medication for weight loss.
- Conditions
- Women's Health, Obesity & Overweight, Perimenopausal Women, Digital Intervention
- Trial name
- PLAN-RT (NCT07787533)
- Testing
- PLAN-RT 1.0
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Louisiana State University and A&M College