Clinical trials: Interventions
Heart Failure, Heart-assist Devices
PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device
The left ventricular assist device (LVAD) is growing rapidly among people dying from end-stage heart failure who are unable to get a heart transplant.
- Trial name
- DECIDE-LVAD (NCT02344576)
- Testing
- DT LVAD Decision Support Intervention
- Where
- 6 sites in United States
- Volunteers
- 445 people
- Sponsor
- University of Colorado, Denver
Gulf War Veteran's Illness
Novel Interventions for GWVI
The primary aim of this study was to examine the beneficial effects of two novel treatments for Gulf War Veteran's Illness (Tai Chi and Wellness intervention) and to establish the efficacy of these mind-body approaches to symptom…
- Trial name
- NIGWVI (NCT02661997)
- Testing
- Tai Chi Intervention, Wellness Intervention
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- VA Office of Research and Development
Opioid-Related Disorders, Drug Overdose
Repeated-dose Behavioral Intervention to Reduce Opioid Overdose
REBOOT is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients with opioid use disorder.
- Trial name
- REBOOT (NCT03838510)
- Testing
- REBOOT
- Where
- 2 sites in United States
- Volunteers
- 268 people
- Sponsor
- San Francisco Department of Public Health
Acute Coronary Syndrome (ACS)
Improving Medication Adherence Through Graphically Enhanced Interventions in Acute Coronary Syndromes
Coronary heart disease (CHD) is the leading cause of death in the United States. Most people who die from CHD die of a heart attack.
- Trial name
- IMAGE-ACS (NCT00399880)
- Testing
- Health literacy intervention
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Vanderbilt University Medical Center
Back Pain, Neck Pain
Spine Pain INtervention to Enhance Care Quality And Reduce Expenditure
Low back and neck pain are among the leading causes of medical visits, lost productivity and disability. There is an urgent need to identify effective and efficient ways of helping subjects with acute spine pain while guiding…
- Trial name
- SPINE CARE (NCT03083886)
- Testing
- Identify, Coordinated, Enhanced (ICE) Decision Making + PCP led care, Individualized Postural Therapy (IPT) + PCP led care, Usual PCP led care
- Where
- 8 sites in United States
- Volunteers
- 3,087 people
- Sponsor
- Brigham and Women's Hospital
Social Anxiety Disorder
Brief Intervention to Reduce Fear of Public Speaking
The study will test the efficacy of propranolol or placebo, administered after retrieval of a previously acquired public speaking fear, in reducing fear and avoidance of public speaking.
- Trial name
- NCT02790736
- Testing
- propranolol
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- New York State Psychiatric Institute
Weight Loss, Obesity
A Trial to Test an Acceptance-based Therapy Program Among Adolescent Girls With Overweight/Obesity
The purpose of this study is to investigate the effects of an acceptance-based therapy weight loss intervention compared with enhanced care for adolescents.
- Conditions
- Weight Loss, Obesity, Overweight
- Trial name
- NCT04484831
- Testing
- ABT Weight Loss Intervention, Enhanced Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Postpartum Smoking Relapse
Perinatal Attentional Retraining Intervention for Smoking for Minority Women
The proposed research intends to randomize 50 abstinent pregnant Black or Hispanic smokers to receive either the attentional retraining (AR) or control VP task.
- Trial name
- PARIS (NCT04114877)
- Testing
- Attentional retraining (AR), Visual probe (VP)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Yale University
Coronary Arteriosclerosis
Study of the Effect of omega3 on Biomarkers of Cardiac Necrosis (CKMB and Troponin I) and Inflammation Marker (CRP) After Elective Percutaneous Coronary Intervention (PCI)
The purpose of this study is to investigate the effect of omega 3 on biomarkers of cardiac necrosis(CKMB and troponin I) and inflammation marker CRP.
- Trial name
- NCT01521845
- Testing
- omega 3
- Where
- Iran
- Volunteers
- 104 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Parkinson Disease
Kick Out Parkinson's Disease- Karate Intervention
The benefits of exercise for general health and wellbeing in older adults are well-established. Balance exercises such as tai chi and yoga, along with resistance training, can improve or maintain physical function in older adults…
- Trial name
- NCT03555695
- Testing
- Karate Classes, Pre-Intervention Focus Group, Post-Intervention Focus Group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Rush University Medical Center
Peripheral Artery Disease, Peripheral Vascular Disease
Investigational Device Exemption Study to Determine the Safety and Efficacy of the Astron and Pulsar Stents
The objective of this study is to separately demonstrate the safety and efficacy of BIOTRONIK's Astron and Pulsar stents. The Pulsar stent will be used for the treatment of femoro-popliteal lesions, located in the native…
- Trial name
- BIOFLEX-I (NCT01319812)
- Testing
- Astron Stents, Pulsar Stents
- Where
- 35 sites in United States, Canada
- Volunteers
- 463 people
- Sponsor
- Biotronik, Inc.
Asthma
Using Technology-Assisted Stepped Care Intervention to Improve Adherence in Adolescents With Asthma
To test the preliminary efficacy of the TASC adherence promotion intervention for adolescents with asthma in a feasibility randomized controlled trial compared to treatment as usual control arm.
- Trial name
- TASC (NCT04365556)
- Testing
- TASC Intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bullying
Middle School Parent Module for a Brief Bullying Intervention Program
This study evaluates the feasibility and short-term outcomes of a parent training designed as a companion module to a bullying bystander intervention (STAC) for middle school students in rural communities.
- Trial name
- NCT06002347
- Testing
- STAC Parent Module for Middle School
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Boise State University
Dementia, Caregiver
Artificial Intelligence + Care Coach Intervention
The purpose of this research study is to develop and test an artificial intelligence intervention for emergency department (ED) discharge care transitions experienced by caregivers of older adults with cognitive impairment.
- Conditions
- Dementia, Caregiver, Emergency Department, Artificial Intelligence
- Trial name
- NCT05352399
- Testing
- NeuViCare application
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Osteoarthritis, Knee
lIfestyle iNterventionS for PaIn ReliEf (INSPIRE)
This is a 2x2 factorial design randomised controlled trial in which participants with knee pain will be grouped into the diet intervention, exercise intervention, diet and exercise intervention or placebo arm.
- Trial name
- INSPIRE (NCT05670314)
- Testing
- Inulin Fibre supplement, Exercise
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Caregiver, Hematologic Malignancy
Proof-of-Concept Trial of a Positive Psychology Intervention for Caregivers of Patients Undergoing HSCT
Caregivers (i.e., family and friends) of patients with cancer are essential in providing care during cancer treatment. For patients who are undergoing a hematopoietic stem cell transplant/transplantation (HSCT) as treatment for…
- Trial name
- PATH-C (NCT05216978)
- Testing
- Positive Psychology Intervention
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Glioblastomas, Sarcoma
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers
Background: People cope with cancer in different ways. Mindfulness means focusing on the present moment with an open mind. Researchers want to see if this can help children and young adults with a high-grade high-risk cancer with…
- Conditions
- Glioblastomas, Sarcoma, Astrocytoma, Brain Cancer
- Trial name
- NCT03538587
- Testing
- Enhanced Mindfulness Intervention, Psychoeducation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Acute Coronary Syndrome, Lipid Disorder
Polypill in Acute Coronary Syndrome
Acute coronary syndromes (ACS) represent a major contributor to mortality, morbidity, and healthcare costs. Effective therapies are widely available; however, adherence is low.
- Conditions
- Acute Coronary Syndrome, Lipid Disorder, Coronary Artery Disease
- Trial name
- POLY-ACS (NCT05514938)
- Testing
- Polypill, Usual Care (individual medications prescribed by primary cardiologist)
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer Female
Optimizing Functional Recovery of Breast Cancer Survivors
This study is a randomized controlled trial (RCT) to test the efficacy of a Behavioral Activation and Problem Solving (BA/PS) approach to improving activity participation over time as compared to an attention control condition…
- Trial name
- NCT03915548
- Testing
- The Behavioral Activation/ Problem Solving Intervention, Attention Control Condition
- Where
- 2 sites in United States
- Volunteers
- 303 people
- Sponsor
- MGH Institute of Health Professions
Stimulant Abuse and Dependence
Exercise as a Treatment for Substance Use Disorders Protocol
The purpose of this study is to investigate if health interventions (intensive exercise or health education) can be used to help improve substance abuse treatment.
- Trial name
- STRIDE (NCT01141608)
- Testing
- Vigorous Intensity High Dose Exercise, Health Education Intervention
- Where
- 9 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of Texas Southwestern Medical Center
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