Clinical trials: Intestinal Absorption
Healthy Volunteer Study
Effect of Charcoal on Gastrointestinal Absorption of Tiotropium
The study will assess how efficiently activated charcoal will block absorption of tiotropium via the gastro intestinal track. Pharmacokinetics of tiotropium will be compared after orally administered tiotropium capsule with and…
- Trial name
- TIOBLOCK (NCT03945344)
- Testing
- Tiotropium
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Critical Illness
Nutrient Uptake During Continuous Enteral Feeding
Continuous enteral nutrition is used to feed patients in intensive care who are unable to eat normally. The goal of this observational study is to learn about the uptake of nutrients from feeding formula.
- Trial name
- NCT05628844
- Testing
- Continuous enteral feeding
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Felix Liebau
Kidney Stone, Kidney Calculi
Gut Oxalate Absorption in Calcium Oxalate Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06331546
- Testing
- Low-oxalate diet, High-oxalate diet, soluble oxalate gut absorption test
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gut -Microbiota, Inflamation
Impact of a Cricket and Black Soldier Fly Larvae-Fortified Cracker on the Gut Microbiome and Iron Status in Malagasy Schoolchildren
The purpose of this study is to determine the health impacts of consistent consumption of insect-fortified crackers among school-aged children in Madagascar.
- Conditions
- Gut -Microbiota, Inflamation, Iron Absorption
- Trial name
- NCT07439185
- Testing
- Cricket and Black Soldier Fly Larvae-fortified Cracker, Rice and Corn Cracker
- Where
- Madagascar
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Cornell University
Cancer Patients Receiving Chemotherapy or Chemoradiotherapy
Nutrition Intervention During Chemotherapy
Weight loss and muscle wasting commonly occurs in patients with cancer, negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01871350
- Testing
- Daily intake for 10 weeks (+/- 2 weeks)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Digestibility
Effects of Time-restricted Eating on Nutrient Absorption in Healthy Adults
This 2-period, crossover, controlled-feeding trial will investigate the effects of early time-restricted eating (8am-2pm), compared to a control eating timeframe (8am-8pm), on energy and macronutrient digestibility, the thermic…
- Trial name
- NCT04877262
- Testing
- weight maintenance diet (WMD)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida State University
Aging
Fiber and Calcium Absorption in Older Men
Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men.
- Trial name
- NCT06519877
- Testing
- Soluble corn fiber
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
the Local Renin-angiotensin System (RAS) in Small Intestinal Mucosa in Man
Effects of Probiotic VSL#3 on Expression of Small Intestinal Renin-angiotensin System
Probiotics have become very popular and are by WHO defined as "Live microorganisms which when administered in adequate amounts confer a health benefit on the host".
- Trial name
- NCT01635192
- Testing
- VSL#3
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Osteoporosis, Osteopenia
Does Treatment of Hypovitaminosis D Increase Calcium Absorption?
The purpose is to perform a one-year study designed to assess whether treatment of hypovitaminosis D increases intestinal absorption of calcium, subsequent retention of calcium within bone, decreases bone turnover, and favorably…
- Conditions
- Osteoporosis, Osteopenia, Vitamin D Deficiency, Hypoparathyroidism
- Trial name
- NCT00581828
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy
Imaging the Effect of Experimental Stress on Small and Large Bowel Water During Fructose Absorption
The investigators have been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the small bowel. Building on those studies the investigators want to study, in healthy volunteers, the effects of…
- Trial name
- NCT01763281
- Testing
- CRH
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
The Effect of LCFA on Nutrient Absorption
Nutrient Sensing in the Duodenum
Preliminary studies in humans suggest that the presence of lipids in the gut can modify glucose absorption. The overall hypothesis of this proposal is that long chain fatty acid sensing in the duodenum has a significant role in…
- Trial name
- NCT01694004
- Testing
- Benzocaine Infusion into Duodenum
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Osteoporosis
The Effect of Protein on Calcium Absorption and Gastric Acid Production
We have established that dietary protein is an important regulator of intestinal calcium absorption in humans. However, we do not understand the mechanism by which dietary protein is affecting calcium absorption.
- Trial name
- NCT00719160
- Testing
- esomeprazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Yale University
Micronutrient Deficiencies
Effect of Sprinkles With and w/o Fe on Zn Absorption in Kenyan Toddlers
The investigators propose to study the effects of increased iron intake by home fortification of complementary foods on the gastrointestinal microbial development, inflammatory responses, and zinc (Zn) absorption.
- Trial name
- NCT02101723
- Testing
- MNP + Zn/Fe, MNP + Zn
- Where
- 2 sites in United States, Kenya
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Nebulizers and Vaporizers
Explorative Clinical Investigation to Investigate the Ability of PreciseInhale to Direct Regional Lung Targeting and Reduce the Degree of Throat Deposition and Subsequent Gastrointestinal Absorption in Healthy Volunteers After Inhalation of Test Drug Substances Via the PreciseInhale System
This is a single site, open label, 4-inhalation sessions, explorative clinical investigation to investigate the ability of PreciseInhale to direct regional lung targeting and reduce the degree of throat deposition and subsequent…
- Trial name
- NCT04946630
- Testing
- PreciseInhale, Seretide Evohaler forte
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Inhalation Sciences Sweden AB
Taste Receptors, Nutrient Sensing
The Effect of Artificial Sweeteners on Blood Glucose Response
The purpose of this study is to determine whether the presece of the artificial sweeteners aspartame, saccharin and asceulfame-k affect the blood glucose responses to an orally incested glucose solution.
- Conditions
- Taste Receptors, Nutrient Sensing, Intestinal Absorption, Blood Glucose
- Trial name
- NCT01246492
- Testing
- Artificial Sweeteners
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northumbria University
HIV Infections
Single Dose Pharmacokinetics of Oral Dextran Sulfate (UA001) and Intravenous Dextran Sulfate in Healthy Volunteers
To evaluate how the drug dextran sulfate (DS) is absorbed by the stomach and intestines when taken by mouth. To evaluate its effect on blood coagulation. DS has been reported to have anti-HIV activity.
- Trial name
- NCT00000690
- Testing
- Dextran sulfate
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Heart Failure, Chronic Obstructive Pulmonary Disorder
Nutritional and Functional Changes in Heart Failure and COPD
Weight loss commonly occurs in patients with chronic heart failure (CHF) and chronic obstructive pulmonary disorder (COPD), negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01787682
- Testing
- BOOST High Protein
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Osteoporosis, Osteopenia
The Effect of Chymosin on the Intestinal Absorption of Calcium
An adequate calcium intake is important for bone turnover and the risk of developing osteoporosis. Yet many studies have documented that supplementation with calcium tablets are often associated with a poor compliance, therefore…
- Trial name
- Chymosin (NCT01370941)
- Testing
- Drug A Chymosin
- Where
- Denmark
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
Long-term Effects of Green Tea on Gut Flora, Fat Absorption, Body Composition and Resting Energy Expenditure
Green tea may have positive effects for weight control and on body composition via several approaches such as a positive effect on the gut flora, a decrease in fat absorption from the intestines and an increase in resting energy…
- Trial name
- NCT01556321
- Testing
- green tea (757 mg/capsule [84.5 mg EGCG + 2.1 mg caffeine ]
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Low Iron Stores
The Effect of Lactobacillus Cultures on Iron Bioavailability.
The purpose of this study is to determine the effect of a lactic acid fermented oat gruel on iron absorption in the upper and lower part of the intestine, respectively.
- Trial name
- NCT00283491
- Testing
- Active Lactobacillus plantarum 299v, Inactive Lactobacillus plantarum 299v
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen