Clinical trials: Intestinal Dysfunction
Small Intestine Bacterial Overgrowth
Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children
The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.
- Trial name
- NCT07451171
- Testing
- Trimethoprim-sulfamethoxazole (TMP/SMX), Metronidazole, Amoxicillin-Clavulanate (4:1 formulation)
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Segmental and Somatic Dysfunction, Pathological Conditions, Signs and Symptoms
Correlation of Somatic Dysfunction With Gastrointestinal Endoscopic Findings
The purpose of this study is to correlate the link between palpatory findings of somatic dysfunction and gastrointestinal endoscopic evidence of changes in mucosa.
- Conditions
- Segmental and Somatic Dysfunction, Pathological Conditions, Signs and Symptoms, Ectopic Intestinal Mucosa
- Trial name
- NCT01394198
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- A.T. Still University of Health Sciences
Postoperative Gastrointestinal Dysfunction
A Study of TAK-954 to Treat Gastrointestinal Dysfunction in Adults After Surgery
The main aim of this study is to check for side effects from TAK-954 and whether it speeds up the recovery of gastrointestinal function after small-bowel or large-bowel resection surgery.
- Trial name
- NCT03827655
- Testing
- TAK-954
- Where
- 25 sites in United States, Germany
- Volunteers
- 209 people
- Sponsor
- Takeda
Ischemic Stroke
Gut Microbiota and Serum Markers for Cognitive Impairment and Poor Prognosis After Ischemic Stroke
Post-stroke cognitive impairment(PSCI) is one of the most important factors causing disabilities after stroke. Recent study found that gut microbiota plays a key role in neurological diseases.
- Trial name
- NCT04688138
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Bowel Dysfunction
Gastrointestinal Activation Post-elective CS (Cesarean Section) :A Comparison of Paula Method to Standard Care
Women generally report discomfort and a delay in GI motility after CS. The Paula method, circular exercises of ring muscles has been shown to increase GI motility. This method had not been studied in women post CS.
- Trial name
- NCT03761147
- Testing
- Paula exercises
- Where
- Israel
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Opioid-Induced Bowel Dysfunction
Opioid-induced Bowel Dysfunction: Pivotal Assessment of Lubiprostone
The primary purpose of this study is to evaluate the efficacy and safety of lubiprostone administration in patients with Opioid-induced Bowel Dysfunction.
- Trial name
- OPAL (NCT00595946)
- Testing
- Lubiprostone
- Where
- 95 sites in United States, Canada
- Volunteers
- 439 people
- Sponsor
- Sucampo Pharma Americas, LLC
Irritable Bowel Syndrome
Effects of Activia in IBS
The purpose of this study is to investigate the association between gut microbiota, immunology and typical pathophysiological factors in patients with IBS (all subtypes) AND to assess the effect of Activia consumption on GI…
- Trial name
- MOSAIC (NCT01252550)
- Testing
- Activia® (125g/pot), Acidified non-fermented dairy product
- Where
- 3 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Environmental Enteric Dysfunction (EED)
Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II)
Burden: Environmental Enteric Dysfunction (EED) is an enteropathic condition characterized by altered gut permeability, infiltration of immune cells and changes in villous architecture and cell differentiation.
- Trial name
- MPIGH-II (NCT07134790)
- Testing
- VE818, Oral Vancomycin
- Where
- Burkina Faso
- Volunteers
- 144 people
- Sponsor
- University Ghent
Constipation, Pain, Postoperative
Opioid Induced Bowel Dysfunction in Patients Undergoing Cesarean Section
Constipation is common in pregnant women. Surgery, anaesthesia and opioid analgesics may further impair bowel function. The aim of the present study was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced…
- Trial name
- oksisektio (NCT02571881)
- Testing
- Caesarean section, Oxycodone, oxycodone-naloxone
- Where
- Finland
- Volunteers
- 57 people
- Sponsor
- Kuopio University Hospital
Anterior Resection Syndrome, Bowel Dysfunction
Studies in Patients With Low Anterior Resection Syndrome (LARS)
Colorectal Cancer is the commonest cancer diagnosed for both genders combined in Hong Kong. In 2015 16.6% of all new cancer cases registered on the Hong Kong registry were cancer of colon and rectum.
- Trial name
- NCT03885999
- Testing
- Fecobionics
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Giome
Glioma, Hematopoietic and Lymphoid Cell Neoplasm
Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction
This phase I trial studies the side effects and best dose of romidepsin in treating patients with lymphoma, chronic lymphocytic leukemia, or solid tumors with liver dysfunction.
- Conditions
- Glioma, Hematopoietic and Lymphoid Cell Neoplasm, Lymphoma, Metastatic Malignant Solid Neoplasm
- Trial name
- NCT01638533
- Testing
- Pharmacological Study, Romidepsin
- Where
- 12 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- National Cancer Institute (NCI)
Bowel Dysfunction, Postoperative Complications
Sugammadex To IMprove Bowel Function
Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission.
- Conditions
- Bowel Dysfunction, Postoperative Complications, Neuromuscular Blockade
- Trial name
- STIM_Bowel (NCT04546672)
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Oregon Health and Science University
Central Nervous System Injury, Neurogenic Bowel Dysfunction
Effects of Osteopathic Manipulative Treatment in People With Neurogenic Bowel Dysfunction
People affected central nervous system (CNS) diseases often suffer from neurogenic bowel dysfunction (NBD) that causes a reduction in the quality of life and participation in social life.
- Trial name
- NCT04127617
- Testing
- Osteopathic Manipulative Treatment, Nursing Educational Care
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Turin, Italy
Low Anterior Resection Syndrome, Rectal Cancer
Bowel Dysfunction 3 Years After Anterior Resection a in a Swedish National Cohort
The primary objectives are to evaluate the prevalence of LARS and Quality of Life in rectal cancer patients 3 years after anterior resection, to investigate if anastomotic technique is a risk factor for major LARS and to study…
- Trial name
- NCT04591821
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Bladder Dysfunction, Bowel Dysfunction
Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
There are many studies in the literature on healthy children with lower urinary tract dysfunction (LUTD), but there are limited number of studies in children with cerebral palsy (CP) with LUTD.
- Conditions
- Bladder Dysfunction, Bowel Dysfunction, Cerebral Palsy, Neurogenic Bladder
- Trial name
- NCT05351138
- Testing
- TENS, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bahçeşehir University
Spinal Cord Injuries, Neurogenic Bowel
Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction
An investigator initiated pilot study: two arm, double blind, placebo controlled, randomized, group of approximately 60 patients with spinal cord injury, and who have evidence of neurogenic bladder.
- Conditions
- Spinal Cord Injuries, Neurogenic Bowel, Bladder Dysfunction
- Trial name
- NCT03987126
- Testing
- Human Milk Oligosaccharides (HMO)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Bladder and Bowel Dysfunction, SCI - Spinal Cord Injury
SCS Therapy for Patients With Bladder and Bowel Dysfunction After SCI
This clinical trial aims to evaluate the safety and efficacy of spinal cord stimulation (SCS) in treating patients with urinary and bowel dysfunction after spinal cord injury (SCI).
- Trial name
- SCSBBD (NCT07511244)
- Testing
- Spinal Cord Stimulation and Evaluation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Intestinal Barrier Dysfunction
Vagal Nerve Stimulation for Intestinal Barrier Dysfunction in Healthy Volunteers
This is a proof of concept randomised placebo controlled crossover trial to evaluate the effect of transcutaneous vagal nerve stimulation on a stress model of increased intestinal permeability in healthy human subjects.
- Trial name
- NCT04061564
- Testing
- Vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Chronic Granulomatous Disease, Crohn'S-like IBD
Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease
This study will determine if the drug infliximab is safe for treating inflammatory bowel disease (IBD) in patients with chronic granulomatous disease (CGD).
- Conditions
- Chronic Granulomatous Disease, Crohn'S-like IBD, Inflammatory Bowel Disease (IBD)
- Trial name
- NCT00325078
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Postoperative Ileus, Delayed Gastrointestinal Motility
Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients
Postoperative ileus (POI) is a frequent complication after abdominal surgery, leading to delayed gastrointestinal motility, prolonged hospital stay, and increased patient discomfort.
- Conditions
- Postoperative Ileus, Delayed Gastrointestinal Motility, Postoperative Gut Dysfunction
- Trial name
- NCT07425249
- Testing
- Chewing Gum
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Khyber Medical University Peshawar