Clinical trials: Intestinal Microbiota
Cardiometabolic Risk, Executive Function
Effects of Diet and Exercise Interventions on Cardiometabolic Risk Markers, Executive Function, and Intestinal Flora
The purpose of this study is to estimate the effects of diet and exercise interventions on body weight, cardiovascular metabolic markers, executive function, and intestinal flora among undergraduate students, as well as the…
- Conditions
- Cardiometabolic Risk, Executive Function, Intestinal Microbiome
- Trial name
- NCT04834687
- Testing
- Exercise, Diet
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Pregnancy
Intestinal Microbiota on Allergy, Growth and Development
There is growing evidence that microbial programming beginning in-utero can be a central component for a balanced development of innate immunity and optimal growth and development in newborns.
- Trial name
- SMARTGenHK (NCT03785093)
- Where
- Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Kidney Diseases, Healthy
NATURE 3.1_New Approach for the Reduction of REnal Uremic Toxins
The objective of the pilot study is to validate the clinical use of an innovative symbiotic in patients with chronic kidney disease (CKD) stage 3b-4 and in healthy subjects.
- Trial name
- NATURE31 (NCT03815786)
- Testing
- Symbiotic
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Weight Loss, Gut Microbiome
Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women
This study will systematically quantify the effects of protein pacing and intermittent fasting (P-IF) on total and regional (abdominal) body composition (lean mass and fat mass), blood glucose and lipids, and anti-aging…
- Conditions
- Weight Loss, Gut Microbiome, Anti-Aging
- Trial name
- NCT04327141
- Testing
- P-IF, HH
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Mild Cognitive Impairment (MCI)
Relationship Between Gut Microbiome, Probiotics, and Mild Cognitive Impairment
This study is to evaluate whether the consumption of probiotics can improve the symptoms of patients with mild cognitive impairment; also evaluate the effects of probiotics on patients' blood, oxidation and stress related…
- Trial name
- NCT04971096
- Testing
- PS23 live, PS23 heat-treated
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Gastrointestinal Symptoms
The Effect of Probiotics on GI Symptoms
A double-blind randomized, placebo-controlled study will be performed with experienced endurance athletes to assess the effect of probiotics supplementation on the occurrence and intensity of the gastrointestinal symptoms, on…
- Trial name
- WHOMLF (NCT03959722)
- Testing
- Ecologic® PERFORMANCE
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Karlijn te Poele
Healthy
Milk Consumption and Blood Microbiome in Healthy Volunteers
The goal of this study is to learn if cfDNA of milk-associated intestinal bacteria (MAIB) is detectable in the bloodstream. The primary question it aims to answer is: Does milk consumption simultaneously increase the number of…
- Trial name
- MAMI (NCT06944002)
- Testing
- Milk product
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Very Preterm Infants
Feeding the Preterm Gut Microbiota - Impact of Infant-feeding on Preterm Gut Microbiota Development
Preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse.
- Trial name
- FEEDMI (NCT03663556)
- Testing
- Infant-feeding
- Where
- 2 sites in Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Gut Microbiome, Gut Microbiota
Effect of Probiotics on Endurance Athletes' Microbiome at Rest and Post-race
This study is intended to investigate the use of probiotics (LAB4 probiotics, Cultech, Port Talbot, Wales, UK) and the effect this has on gastrointestinal symptoms experienced during elite long-distance triathlon (ironman)…
- Conditions
- Gut Microbiome, Gut Microbiota, Aerobic Exercise, Gastrointestinal Tract Irritation
- Trial name
- NCT05615961
- Testing
- Probiotics (Lab4 probiotics, Cultech, Port Talbot, Wales, UK)
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Athlete, Probiotic
Clinical Trial of Lactiplantibacillus Plantarum Dad-13 on Gut Microbiota Profile and Performance in Adolescent Athletes
The aim of this research is to analyze the effect of a Lactiplantibacillus plantarum Dad-13 supplementation on the gut microbiota profile and performance of adolescent athletes.
- Conditions
- Athlete, Probiotic, Performance, Gut Microbiota
- Trial name
- Dad-13 (NCT07476573)
- Testing
- Probiotic Lactiplantibacillus plantarum Dad-13
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Kefir Usual Consumers and New Kefir Consumers
Activia Kefir Consumption in Real-world Setting
The study aims at generating first real-world insights into how consumers perceive the benefits of consuming Activia Kefir on their digestive wellbeing, overall wellbeing, and to explore its potential effects on the gut…
- Trial name
- KefirSelf (NCT07790666)
- Testing
- Commercialized dairy product consumption and stool samples collection
- Where
- 3 sites in Spain
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Skin Health
Dealcoholized Muscadine Wine and Skin Health in Women
The objective of this clinical trial is to determine the activity of dealcoholized muscadine wine to alleviate oxidative stress, inflammation, skin photoaging, and alter gut microbiome in women 40-67 years of age.
- Trial name
- NCT04614753
- Testing
- Dealcoholized Muscadine Wine, Control Beverage
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Digestive Health, Quality of Life
Protein-Prebiotic Wellbeing Study
Healthy participants with self-reported GI complaints will consume the protein supplement that they normally use for recovery purposes after exercise during a 3-week baseline period, followed by a 3-week intervention period in…
- Trial name
- NCT05303753
- Testing
- fermented dairy protein with prebiotic fiber
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Diet, Healthy
The Effects of Dietary Fibres on Metabolic Health and the Gut Microbiome
The study involves intake of dietary supplements, which are commonly found in the UK diet (not pharmacological agents) to test their effects on inflammation in the body and gut microbiome composition.
- Conditions
- Diet, Healthy, Systemic Inflammatory Response
- Trial name
- NCT06580132
- Testing
- Pectin, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Smoking Cessation, Weight Gain
Gut Microbiome and Weight Gain After Smoking Cessation
Investigating the effect of smoking and smoking cessation on the intestinal microbial composition and function. The investigators wish to determine whether the alteration in gut microbiome drives the significant weight gain seen…
- Trial name
- NCT04618705
- Testing
- Smoking Cessation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eran Elinav
Parkinson Disease
The Parkinson's Disease Case-Control Study
The Parkinson's Disease Case-Control Study is a study of healthy volunteers and patients with Parkinson's disease aged 50-75 years living in Hangzhou, China.
- Trial name
- NCT06848192
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Evidence of Adaptation to Dietary Exposure to Fructans
Pilot Study of the Effect of Fructans on Fermentation in the Colon & Transit
Some carbohydrates (complex sugars) which are found in grains, fruit and vegetables, cannot be digested by humans. When eaten they pass through the small bowel to the large bowel, or colon.
- Trial name
- PERFECT (NCT01963364)
- Testing
- Inulin challenge, oligofructose supplement
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Upper Respiratory Tract Infection, Gut Microbiota
The Effect of Synbiotics on the Upper Respiratory Tract Infection
Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections. However, clinical trials of synbiotics, one of the microbiota-targeted intervention, in this regard is few.
- Conditions
- Upper Respiratory Tract Infection, Gut Microbiota, Immune Function
- Trial name
- NCT04960878
- Testing
- Synbiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Analysis of Microbiota Changes Induced by Microencapsulated Sodium Butyrate in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is characterized by severe inflammation of the small bowel and/or the colon leading to recurrent diarrhea and abdominal pain.
- Trial name
- IBDMicro (NCT04879914)
- Testing
- Butyrate
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Padova
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